AutismKB 2.0

Annotation Detail for AKT1


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:AKT1 ( AKT,MGC99656,PKB,PKB-ALPHA,PRKBA,RAC,RAC-ALPHA )
Gene Full Name: v-akt murine thymoma viral oncogene homolog 1
Band: 14q32.33
Quick LinksEntrez ID:207; OMIM: 164730; Uniprot ID:AKT1_HUMAN; ENSEMBL ID: ENSG00000142208; HGNC ID: 391
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body15 / 70761211
blastocyst6 / 6231996
fetus52 / 56401292
neonate2 / 3109764
infant4 / 23620169
juvenile2 / 5555635
adult251 / 1939121129
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma0 / 174750 
breast (mammary gland) tumor36 / 94178382
cervical tumor6 / 34366174
chondrosarcoma19 / 82823229
colorectal tumor17 / 114246148
esophageal tumor0 / 172900 
gastrointestinal tumor25 / 119369209
germ cell tumor30 / 263845113
glioma35 / 106883327
head and neck tumor40 / 136302293
kidney tumor21 / 68959304
leukemia12 / 95842125
liver tumor39 / 96359404
lung tumor44 / 103127426
lymphoma31 / 71755432
non-neoplasia4 / 9725041
normal309 / 336030791
ovarian tumor23 / 76682299
pancreatic tumor44 / 104616420
primitive neuroectodermal tumor of the CNS12 / 12568095
prostate cancer60 / 102680584
retinoblastoma13 / 46356280
skin tumor55 / 124949440
soft tissue/muscle tissue tumor23 / 125191183
uterine tumor31 / 90257343
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue3 / 13106228
adrenal gland5 / 33197150
ascites16 / 40015399
bladder4 / 29757134
blood11 / 12347889
bone10 / 71655139
bone marrow7 / 48801143
brain102 / 110098992
cervix7 / 48171145
connective tissue14 / 14925593
ear0 / 162120 
embryonic tissue33 / 215722152
esophagus0 / 202090 
eye45 / 211054213
heart10 / 89626111
intestine34 / 234472145
kidney27 / 211777127
larynx5 / 24145207
liver45 / 207743216
lung73 / 336974216
lymph30 / 44270677
lymph node16 / 91610174
mammary gland47 / 153271306
mouth6 / 6705289
muscle21 / 107715194
nerve2 / 15768126
ovary28 / 102051274
pancreas53 / 214812246
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta33 / 280825117
prostate70 / 189345369
salivary gland22 / 201551091
skin60 / 210574284
spleen1 / 5395218
stomach8 / 9661982
testis14 / 33044242
thymus3 / 8113136
thyroid11 / 47473231
tonsil10 / 16999588
trachea1 / 5241319
umbilical cord1 / 1368073
uterus45 / 232878193
vascular2 / 5178038
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 207163_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts75
Adipocyte24.3
AdrenalCortex28.7
Adrenalgland23.2
Amygdala24.75
Appendix17.75
AtrioventricularNode14.05
BDCA4+_DentriticCells75.05
Bonemarrow18.55
BronchialEpithelialCells38.8
CD105+_Endothelial24.55
CD14+_Monocytes93.45
CD19+_BCells(neg._sel.)32.2
CD33+_Myeloid100.9
CD34+131.35
CD4+_Tcells38.6
CD56+_NKCells208.4
CD71+_EarlyErythroid20.7
CD8+_Tcells45.45
CardiacMyocytes39.75
Caudatenucleus18.6
Cerebellum15.9
CerebellumPeduncles23.95
CiliaryGanglion14.05
CingulateCortex19.75
Colorectaladenocarcinoma94.2
DorsalRootGanglion15.4
FetalThyroid29.5
Fetalbrain32.65
Fetalliver13.5
Fetallung33.85
GlobusPallidus13.55
Heart110.6
Hypothalamus19.9
Kidney17.25
Leukemia_chronicMyelogenousK-56221.75
Leukemia_promyelocytic-HL-6032
Leukemialymphoblastic(MOLT-4)63.65
Liver125.65
Lung220.75
Lymphnode13.9
Lymphoma_burkitts(Daudi)26.4
Lymphoma_burkitts(Raji)55.3
MedullaOblongata20.35
OccipitalLobe17.65
OlfactoryBulb16.35
Ovary11.7
Pancreas17.9
PancreaticIslet28.1
ParietalLobe21.75
Pituitary17.8
Placenta27.45
Pons19.2
PrefrontalCortex27.5
Prostate224.55
Salivarygland13.15
SkeletalMuscle14.7
Skin15.4
SmoothMuscle29.05
Spinalcord21.85
SubthalamicNucleus18.45
SuperiorCervicalGanglion20.9
TemporalLobe18.75
Testis15.55
TestisGermCell15.3
TestisIntersitial13.65
TestisLeydigCell12.1
TestisSeminiferousTubule14.5
Thalamus19.9
Thymus22.25
Thyroid129.25
Tongue16.3
Tonsil19.15
Trachea16.95
TrigeminalGanglion18.4
Uterus20.4
UterusCorpus16.35
WholeBlood100.45
Wholebrain40.6
colon23.55
pineal_day27.94
pineal_night27.3
retina37.575
small_intestine20.8
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_16922_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala3.63 ± 0.75
Basal Forebrain3.4 ± 0.32
Basal Part of Pons3.67 ± 0.71
Cerebellar Cortex3.7 ± 0.6
Cerebellar Nuclei3.53 ± 0.48
Claustrum3.65 ± 0.66
Epithalamus3.44 ± 0.45
Frontal Lobe3.52 ± 0.55
Globus Pallidus3.64 ± 0.74
Hypothalamus3.43 ± 0.47
Insula3.51 ± 0.54
Limbic Lobe3.56 ± 0.58
Mesencephalon3.65 ± 0.67
Myelencephalon3.62 ± 0.54
Occipital Lobe3.64 ± 0.49
Parietal Lobe3.56 ± 0.47
Pontine Tegmentum3.46 ± 0.55
Striatum3.81 ± 0.59
Subthalamus3.56 ± 0.37
Temporal Lobe3.64 ± 0.56
Thalamus3.61 ± 0.59
White Matter3.55 ± 0.96
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Akt1CBCerebellum38.76
55.66
Akt1CTXCerebral cortex100
90.12
Akt1HIPHippocampal region61.5
96.14
Akt1HPFHippocampal formation78.9
86.67
Akt1HYHypothalamus100
80.86
Akt1LSXLateral septal complex67.19
34.09
Akt1MBMidbrain100
81.65
Akt1MYMedulla94.21
94.8
Akt1OLFOlfactory bulb98.83
69.37
Akt1PPons99.24
96.16
Akt1PALPallidum100
80.63
Akt1RHPRetrohippocampal region100
78.58
Akt1sAMYStriatum-like amygdalar nuclei100
73.58
Akt1STRStriatum95.91
51.2
Akt1STRdStriatum dorsal region90.58
47.86
Akt1STRvStriatum ventral region100
58.23
Akt1THThalamus94.31
64.34
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
AKT1_HUMAN_112 10 112 121 KQEEEEMDFR PRIDE
AKT1_HUMAN_113 9 113 121 QEEEEMDFR PRIDE
PAp00011660 21 308 328 TFCGTPEYLAPEVLEDNDYGR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved