AutismKB 2.0

Annotation Detail for EYA4


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Basic Information Top
Gene Symbol:EYA4 ( CMD1J,DFNA10 )
Gene Full Name: eyes absent homolog 4 (Drosophila)
Band: 6q23.2
Quick LinksEntrez ID:2070; OMIM: 603550; Uniprot ID:EYA4_HUMAN; ENSEMBL ID: ENSG00000112319; HGNC ID: 3522
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus3 / 5640125
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult15 / 19391217
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma1 / 1747557
breast (mammary gland) tumor0 / 941780 
cervical tumor1 / 3436629
chondrosarcoma0 / 828230 
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor1 / 2638453
glioma0 / 1068830 
head and neck tumor0 / 1363020 
kidney tumor0 / 689590 
leukemia0 / 958420 
liver tumor0 / 963590 
lung tumor2 / 10312719
lymphoma0 / 717550 
non-neoplasia1 / 9725010
normal22 / 33603076
ovarian tumor1 / 7668213
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS3 / 12568023
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor1 / 1249498
soft tissue/muscle tissue tumor1 / 1251917
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood0 / 1234780 
bone2 / 7165527
bone marrow0 / 488010 
brain7 / 11009896
cervix1 / 4817120
connective tissue0 / 1492550 
ear2 / 16212123
embryonic tissue0 / 2157220 
esophagus0 / 202090 
eye0 / 2110540 
heart0 / 896260 
intestine0 / 2344720 
kidney0 / 2117770 
larynx0 / 241450 
liver1 / 2077434
lung3 / 3369748
lymph0 / 442700 
lymph node0 / 916100 
mammary gland0 / 1532710 
mouth1 / 6705214
muscle6 / 10771555
nerve0 / 157680 
ovary1 / 1020519
pancreas0 / 2148120 
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta0 / 2808250 
prostate0 / 1893450 
salivary gland0 / 201550 
skin1 / 2105744
spleen0 / 539520 
stomach0 / 966190 
testis5 / 33044215
thymus3 / 8113136
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus2 / 2328788
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 207327_at
Cell line Expression level Expression bar
721_B_lymphoblasts7.6
Adipocyte6.2
AdrenalCortex7.5
Adrenalgland5.55
Amygdala6.6
Appendix7.85
AtrioventricularNode6.55
BDCA4+_DentriticCells6.5
Bonemarrow6.7
BronchialEpithelialCells6.3
CD105+_Endothelial6.35
CD14+_Monocytes6.7
CD19+_BCells(neg._sel.)6.85
CD33+_Myeloid7.8
CD34+7.65
CD4+_Tcells6.6
CD56+_NKCells7.6
CD71+_EarlyErythroid6.1
CD8+_Tcells6.1
CardiacMyocytes9.15
Caudatenucleus5.8
Cerebellum5.2
CerebellumPeduncles7.45
CiliaryGanglion6.25
CingulateCortex6.7
Colorectaladenocarcinoma6.35
DorsalRootGanglion5.8
FetalThyroid6.3
Fetalbrain6.4
Fetalliver5.7
Fetallung4.85
GlobusPallidus4.95
Heart10.25
Hypothalamus6.7
Kidney5.75
Leukemia_chronicMyelogenousK-5625.75
Leukemia_promyelocytic-HL-606.45
Leukemialymphoblastic(MOLT-4)5.05
Liver9.8
Lung7
Lymphnode5.3
Lymphoma_burkitts(Daudi)8.35
Lymphoma_burkitts(Raji)9.35
MedullaOblongata5.9
OccipitalLobe5.65
OlfactoryBulb5.05
Ovary4.9
Pancreas5.4
PancreaticIslet6.75
ParietalLobe7
Pituitary7.55
Placenta6.3
Pons6.2
PrefrontalCortex7.65
Prostate7.55
Salivarygland5.2
SkeletalMuscle9.55
Skin8.35
SmoothMuscle7.2
Spinalcord6.85
SubthalamicNucleus6.3
SuperiorCervicalGanglion8.75
TemporalLobe6.2
Testis5.5
TestisGermCell5.1
TestisIntersitial5.6
TestisLeydigCell6.4
TestisSeminiferousTubule5.55
Thalamus6.7
Thymus4.95
Thyroid7.75
Tongue7.2
Tonsil6.3
Trachea5.35
TrigeminalGanglion7.85
Uterus5.2
UterusCorpus6.5
WholeBlood6.95
Wholebrain5
colon6.5
pineal_day8.26
pineal_night8.64
retina7.875
small_intestine6.15
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_32_P219620
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala3.81 ± 0.9
Basal Forebrain3.6 ± 0.69
Basal Part of Pons3.99 ± 0.76
Cerebellar Cortex3.17 ± 0.71
Cerebellar Nuclei5.05 ± 0.72
Claustrum3.54 ± 0.75
Epithalamus6.07 ± 1.07
Frontal Lobe4.07 ± 0.84
Globus Pallidus5.51 ± 0.62
Hypothalamus3.14 ± 0.72
Insula3.17 ± 0.75
Limbic Lobe3.54 ± 0.74
Mesencephalon4.7 ± 1.07
Myelencephalon4.16 ± 1.13
Occipital Lobe5.3 ± 0.98
Parietal Lobe4.59 ± 0.69
Pontine Tegmentum4.14 ± 0.76
Striatum3.79 ± 1.23
Subthalamus4.06 ± 0.85
Temporal Lobe3.91 ± 0.9
Thalamus4.81 ± 0.99
White Matter6.92 ± 0.71
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Eya4CBCerebellum3.88
4.85
Eya4CTXCerebral cortex8.58
6.75
Eya4HIPHippocampal region3.39
3.57
Eya4HPFHippocampal formation3.61
3.36
Eya4HYHypothalamus1.54
1.29
Eya4LSXLateral septal complex2.56
2.61
Eya4MBMidbrain2.65
2.63
Eya4MYMedulla2.79
3.94
Eya4OLFOlfactory bulb3.42
2.74
Eya4PPons1.48
1.89
Eya4PALPallidum1.03
0.88
Eya4RHPRetrohippocampal region4.01
3.02
Eya4sAMYStriatum-like amygdalar nuclei1.54
1.47
Eya4STRStriatum1.49
1.17
Eya4STRdStriatum dorsal region1.26
1.03
Eya4STRvStriatum ventral region1.8
1.01
Eya4THThalamus2.15
1.7
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00011646 14 15 28 TCTESDVSQSQNSR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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