AutismKB 2.0

Annotation Detail for MECOM


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Basic Information Top
Gene Symbol:MECOM ( AML1-EVI-1,EVI1,MDS1,MDS1-EVI1,MGC163392,MGC97004,PRDM3 )
Gene Full Name: MDS1 and EVI1 complex locus
Band: 3q26.2
Quick LinksEntrez ID:2122; OMIM: 165215; Uniprot ID:EVI1_HUMAN; ENSEMBL ID: ENSG00000085276,ENSG00000244102; HGNC ID: 3498
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Microarray in BioGPS Top
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  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 221884_at
Cell line Expression level Expression bar
721_B_lymphoblasts7.05
Adipocyte6.35
AdrenalCortex7.65
Adrenalgland5.6
Amygdala6.35
Appendix7.45
AtrioventricularNode5.75
BDCA4+_DentriticCells6.3
Bonemarrow6.8
BronchialEpithelialCells6.6
CD105+_Endothelial6.3
CD14+_Monocytes6.75
CD19+_BCells(neg._sel.)6.6
CD33+_Myeloid7.7
CD34+20.55
CD4+_Tcells6.4
CD56+_NKCells7.1
CD71+_EarlyErythroid6.2
CD8+_Tcells5.65
CardiacMyocytes27.6
Caudatenucleus5.8
Cerebellum5.25
CerebellumPeduncles7.75
CiliaryGanglion5.05
CingulateCortex7.55
Colorectaladenocarcinoma6.35
DorsalRootGanglion5.4
FetalThyroid8.05
Fetalbrain6.2
Fetalliver5.7
Fetallung38.15
GlobusPallidus5.05
Heart9.8
Hypothalamus6.55
Kidney12.3
Leukemia_chronicMyelogenousK-5625.8
Leukemia_promyelocytic-HL-605.7
Leukemialymphoblastic(MOLT-4)4.9
Liver9.55
Lung10.7
Lymphnode5.3
Lymphoma_burkitts(Daudi)8.55
Lymphoma_burkitts(Raji)9.6
MedullaOblongata5.65
OccipitalLobe5.7
OlfactoryBulb5.05
Ovary4.55
Pancreas11.4
PancreaticIslet19.15
ParietalLobe7.1
Pituitary7.9
Placenta6.35
Pons6.2
PrefrontalCortex7.75
Prostate7.65
Salivarygland6.35
SkeletalMuscle9.55
Skin5.45
SmoothMuscle14.95
Spinalcord6.8
SubthalamicNucleus6
SuperiorCervicalGanglion8.85
TemporalLobe6
Testis5.55
TestisGermCell5.3
TestisIntersitial5.9
TestisLeydigCell6.65
TestisSeminiferousTubule6
Thalamus6.6
Thymus4.9
Thyroid7.85
Tongue7
Tonsil6.35
Trachea19.1
TrigeminalGanglion7.65
Uterus16.7
UterusCorpus7.8
WholeBlood7.1
Wholebrain5.05
colon57.65
pineal_day7.74
pineal_night7.62
retina7.85
small_intestine8.1
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P125726
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala6.35 ± 0.44
Basal Forebrain6.81 ± 0.26
Basal Part of Pons5.81 ± 0.37
Cerebellar Cortex5.81 ± 0.17
Cerebellar Nuclei5.72 ± 0.51
Claustrum5.7 ± 0.72
Epithalamus6.66 ± 0.4
Frontal Lobe6.27 ± 0.42
Globus Pallidus6.09 ± 0.34
Hypothalamus6.57 ± 0.25
Insula6.49 ± 0.34
Limbic Lobe5.95 ± 0.51
Mesencephalon6.28 ± 0.61
Myelencephalon6.36 ± 0.59
Occipital Lobe5.8 ± 0.46
Parietal Lobe6.3 ± 0.57
Pontine Tegmentum6.22 ± 0.52
Striatum6.99 ± 0.49
Subthalamus6.2 ± 0.55
Temporal Lobe6.4 ± 0.39
Thalamus6.7 ± 0.51
White Matter4.3 ± 0.05
Mouse Brain ISH
Peptide Top

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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018