AutismKB 2.0

Annotation Detail for ALDH3A1


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Basic Information Top
Gene Symbol:ALDH3A1 ( ALDH3,ALDHIII,MGC10406 )
Gene Full Name: aldehyde dehydrogenase 3 family, member A1
Band: 17p11.2
Quick LinksEntrez ID:218; OMIM: 100660; Uniprot ID:AL3A1_HUMAN; ENSEMBL ID: ENSG00000108602; HGNC ID: 405
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus1 / 5640121
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult189 / 193912197
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor4 / 34366116
chondrosarcoma0 / 828230 
colorectal tumor4 / 11424635
esophageal tumor8 / 17290462
gastrointestinal tumor74 / 119369619
germ cell tumor6 / 26384522
glioma6 / 10688356
head and neck tumor30 / 136302220
kidney tumor0 / 689590 
leukemia0 / 958420 
liver tumor2 / 9635920
lung tumor122 / 1031271183
lymphoma0 / 717550 
non-neoplasia103 / 972501059
normal44 / 336030713
ovarian tumor0 / 766820 
pancreatic tumor88 / 104616841
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor1 / 1249498
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor5 / 9025755
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites33 / 40015824
bladder1 / 2975733
blood0 / 1234780 
bone0 / 716550 
bone marrow0 / 488010 
brain13 / 110098911
cervix4 / 4817183
connective tissue0 / 1492550 
ear0 / 162120 
embryonic tissue0 / 2157220 
esophagus22 / 202091088
eye114 / 211054540
heart0 / 896260 
intestine8 / 23447234
kidney0 / 2117770 
larynx2 / 2414582
liver2 / 2077439
lung136 / 336974403
lymph0 / 442700 
lymph node0 / 916100 
mammary gland0 / 1532710 
mouth22 / 67052328
muscle0 / 1077150 
nerve0 / 157680 
ovary0 / 1020510 
pancreas88 / 214812409
parathyroid0 / 205390 
pharynx1 / 4132824
pituitary gland0 / 165850 
placenta0 / 2808250 
prostate1 / 1893455
salivary gland5 / 20155248
skin1 / 2105744
spleen0 / 539520 
stomach52 / 96619538
testis1 / 3304423
thymus2 / 8113124
thyroid0 / 474730 
tonsil0 / 169990 
trachea20 / 52413381
umbilical cord0 / 136800 
uterus5 / 23287821
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 205623_at
Cell line Expression level Expression bar
721_B_lymphoblasts9.8
Adipocyte8.35
AdrenalCortex9.15
Adrenalgland7.25
Amygdala8.5
Appendix8.75
AtrioventricularNode6.6
BDCA4+_DentriticCells8.65
Bonemarrow8.9
BronchialEpithelialCells49.4
CD105+_Endothelial8.55
CD14+_Monocytes9.2
CD19+_BCells(neg._sel.)8.3
CD33+_Myeloid9.75
CD34+10.85
CD4+_Tcells9.45
CD56+_NKCells10.1
CD71+_EarlyErythroid8
CD8+_Tcells8.15
CardiacMyocytes11.8
Caudatenucleus9.5
Cerebellum7.25
CerebellumPeduncles13.15
CiliaryGanglion6.05
CingulateCortex8.8
Colorectaladenocarcinoma9.5
DorsalRootGanglion6.4
FetalThyroid8.25
Fetalbrain8.2
Fetalliver7.35
Fetallung6.95
GlobusPallidus6.85
Heart11.25
Hypothalamus9.25
Kidney9.55
Leukemia_chronicMyelogenousK-5628
Leukemia_promyelocytic-HL-607.55
Leukemialymphoblastic(MOLT-4)6.9
Liver11.15
Lung160.65
Lymphnode7.45
Lymphoma_burkitts(Daudi)10.8
Lymphoma_burkitts(Raji)12
MedullaOblongata7.75
OccipitalLobe8.05
OlfactoryBulb6.7
Ovary5.6
Pancreas6.8
PancreaticIslet9.15
ParietalLobe9.05
Pituitary10
Placenta8.55
Pons8.15
PrefrontalCortex8.35
Prostate9.8
Salivarygland6.85
SkeletalMuscle10.1
Skin8.9
SmoothMuscle9.75
Spinalcord9.4
SubthalamicNucleus7.8
SuperiorCervicalGanglion10.05
TemporalLobe8.25
Testis7.4
TestisGermCell7.25
TestisIntersitial7.2
TestisLeydigCell8.5
TestisSeminiferousTubule9.15
Thalamus8.7
Thymus6.75
Thyroid9.7
Tongue327.8
Tonsil21.8
Trachea1297.95
TrigeminalGanglion8.6
Uterus7
UterusCorpus7.55
WholeBlood9.2
Wholebrain6.65
colon8.4
pineal_day9.66
pineal_night9.84
retina12.725
small_intestine8.15
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_16408_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala1.85 ± 1.01
Basal Forebrain1.29 ± 0.2
Basal Part of Pons1.02 ± 0.39
Cerebellar Cortex1.33 ± 0.74
Cerebellar Nuclei1.62 ± 0.69
Claustrum2.24 ± 1.1
Epithalamus1.01 ± 0.73
Frontal Lobe1.23 ± 0.69
Globus Pallidus1.83 ± 0.48
Hypothalamus1.42 ± 0.73
Insula1.16 ± 0.6
Limbic Lobe1.39 ± 0.68
Mesencephalon1.49 ± 0.7
Myelencephalon1.41 ± 0.69
Occipital Lobe1.33 ± 0.69
Parietal Lobe1.35 ± 0.79
Pontine Tegmentum1.43 ± 0.76
Striatum1.55 ± 0.72
Subthalamus1.46 ± 0.62
Temporal Lobe1.32 ± 0.73
Thalamus1.3 ± 0.65
White Matter1.59 ± 0.22
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Aldh3a1CBCerebellum0.48
0.7
Aldh3a1CTXCerebral cortex1.06
0.8
Aldh3a1HIPHippocampal region0.42
0.66
Aldh3a1HPFHippocampal formation0.54
0.62
Aldh3a1HYHypothalamus0.16
0.15
Aldh3a1LSXLateral septal complex0.34
0.23
Aldh3a1MBMidbrain0.52
0.48
Aldh3a1MYMedulla0.51
0.56
Aldh3a1OLFOlfactory bulb0.79
0.5
Aldh3a1PPons0.68
0.55
Aldh3a1PALPallidum0.42
0.47
Aldh3a1RHPRetrohippocampal region0.71
0.56
Aldh3a1sAMYStriatum-like amygdalar nuclei0.8
0.73
Aldh3a1STRStriatum0.61
0.52
Aldh3a1STRdStriatum dorsal region0.65
0.56
Aldh3a1STRvStriatum ventral region0.56
0.47
Aldh3a1THThalamus0.25
0.3
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
AL3A1_HUMAN_2 9 2 10 SKISEAVKR PRIDE
AL3A1_HUMAN_347 12 347 358 SLEEAIQFINQR PRIDE
AL3A1_HUMAN_35 19 35 53 LIQEQEQELVGALAADLHK PRIDE
AL3A1_HUMAN_432 11 432 442 PLMNDEGLKVR PRIDE
PAp00033805 14 181 194 FDHILYTGSTGVGK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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