AutismKB 2.0

Annotation Detail for ACSL4


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:ACSL4 ( ACS4,FACL4,LACS4,MRX63,MRX68 )
Gene Full Name: acyl-CoA synthetase long-chain family member 4
Band: Xq23
Quick LinksEntrez ID:2182; OMIM: 300157; Uniprot ID:ACSL4_HUMAN; ENSEMBL ID: ENSG00000068366; HGNC ID: 3571
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body9 / 70761127
blastocyst3 / 6231948
fetus26 / 56401246
neonate2 / 3109764
infant0 / 236200 
juvenile2 / 5555635
adult126 / 193912164
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma0 / 174750 
breast (mammary gland) tumor3 / 9417831
cervical tumor1 / 3436629
chondrosarcoma6 / 8282372
colorectal tumor1 / 1142468
esophageal tumor1 / 1729057
gastrointestinal tumor5 / 11936941
germ cell tumor20 / 26384575
glioma5 / 10688346
head and neck tumor7 / 13630251
kidney tumor5 / 6895972
leukemia3 / 9584231
liver tumor9 / 9635993
lung tumor7 / 10312767
lymphoma2 / 7175527
non-neoplasia2 / 9725020
normal237 / 336030770
ovarian tumor3 / 7668239
pancreatic tumor1 / 1046169
primitive neuroectodermal tumor of the CNS4 / 12568031
prostate cancer2 / 10268019
retinoblastoma0 / 463560 
skin tumor7 / 12494956
soft tissue/muscle tissue tumor5 / 12519139
uterine tumor6 / 9025766
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue6 / 13106457
adrenal gland3 / 3319790
ascites0 / 400150 
bladder2 / 2975767
blood6 / 12347848
bone3 / 7165541
bone marrow3 / 4880161
brain75 / 110098968
cervix1 / 4817120
connective tissue10 / 14925566
ear0 / 162120 
embryonic tissue14 / 21572264
esophagus1 / 2020949
eye6 / 21105428
heart5 / 8962655
intestine3 / 23447212
kidney19 / 21177789
larynx1 / 2414541
liver15 / 20774372
lung22 / 33697465
lymph2 / 4427045
lymph node12 / 91610130
mammary gland4 / 15327126
mouth4 / 6705259
muscle9 / 10771583
nerve2 / 15768126
ovary4 / 10205139
pancreas2 / 2148129
parathyroid0 / 205390 
pharynx1 / 4132824
pituitary gland0 / 165850 
placenta42 / 280825149
prostate4 / 18934521
salivary gland1 / 2015549
skin16 / 21057475
spleen2 / 5395237
stomach7 / 9661972
testis27 / 33044281
thymus4 / 8113149
thyroid2 / 4747342
tonsil0 / 169990 
trachea14 / 52413267
umbilical cord0 / 136800 
uterus14 / 23287860
vascular2 / 5178038
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 202422_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts12.55
Adipocyte16.75
AdrenalCortex12.75
Adrenalgland25.25
Amygdala61.45
Appendix13.35
AtrioventricularNode9.15
BDCA4+_DentriticCells11.1
Bonemarrow10.3
BronchialEpithelialCells31.7
CD105+_Endothelial9.55
CD14+_Monocytes11.4
CD19+_BCells(neg._sel.)10
CD33+_Myeloid30.6
CD34+11.8
CD4+_Tcells9.1
CD56+_NKCells10.6
CD71+_EarlyErythroid9.15
CD8+_Tcells8.05
CardiacMyocytes16.75
Caudatenucleus8.6
Cerebellum8.15
CerebellumPeduncles12.15
CiliaryGanglion9.7
CingulateCortex10.6
Colorectaladenocarcinoma48.5
DorsalRootGanglion9.2
FetalThyroid9.8
Fetalbrain37.8
Fetalliver491.25
Fetallung76.75
GlobusPallidus7.7
Heart15.1
Hypothalamus16.85
Kidney8.6
Leukemia_chronicMyelogenousK-5628.9
Leukemia_promyelocytic-HL-6016.7
Leukemialymphoblastic(MOLT-4)7.25
Liver15.05
Lung10.3
Lymphnode8.05
Lymphoma_burkitts(Daudi)16
Lymphoma_burkitts(Raji)29.4
MedullaOblongata8.7
OccipitalLobe9
OlfactoryBulb7.25
Ovary11.25
Pancreas8.2
PancreaticIslet10.85
ParietalLobe11.4
Pituitary10.6
Placenta15.35
Pons10.75
PrefrontalCortex14.2
Prostate11
Salivarygland8.35
SkeletalMuscle14.55
Skin9.6
SmoothMuscle28.1
Spinalcord10.45
SubthalamicNucleus9.2
SuperiorCervicalGanglion16.45
TemporalLobe9.9
Testis7.8
TestisGermCell14.1
TestisIntersitial8.65
TestisLeydigCell10.3
TestisSeminiferousTubule8.45
Thalamus11.35
Thymus6.95
Thyroid13.65
Tongue12.4
Tonsil9.9
Trachea9.8
TrigeminalGanglion12.55
Uterus35.5
UterusCorpus10.2
WholeBlood99.6
Wholebrain7.85
colon10.2
pineal_day11.98
pineal_night11.46
retina11.8
small_intestine18.7
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_15065_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala8.36 ± 0.42
Basal Forebrain8.1 ± 0.23
Basal Part of Pons8.18 ± 0.24
Cerebellar Cortex8.11 ± 0.23
Cerebellar Nuclei8.41 ± 0.38
Claustrum8.62 ± 0.24
Epithalamus7.72 ± 0.63
Frontal Lobe8.54 ± 0.35
Globus Pallidus7.63 ± 0.49
Hypothalamus8.63 ± 0.31
Insula8.65 ± 0.32
Limbic Lobe8.55 ± 0.45
Mesencephalon8.28 ± 0.55
Myelencephalon8.28 ± 0.5
Occipital Lobe7.9 ± 0.56
Parietal Lobe8.36 ± 0.36
Pontine Tegmentum8.39 ± 0.48
Striatum7.86 ± 0.49
Subthalamus8.76 ± 0.45
Temporal Lobe8.5 ± 0.3
Thalamus8.33 ± 0.34
White Matter8.28 ± 0.51
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Acsl4CBCerebellum5.12
6.17
Acsl4CTXCerebral cortex7.47
5.78
Acsl4HIPHippocampal region7.92
8.56
Acsl4HPFHippocampal formation6.42
6.21
Acsl4HYHypothalamus0.43
0.4
Acsl4LSXLateral septal complex0.72
0.67
Acsl4MBMidbrain0.66
0.76
Acsl4MYMedulla2.03
2.12
Acsl4OLFOlfactory bulb6.98
6.34
Acsl4PPons1.4
2.18
Acsl4PALPallidum1.84
1.68
Acsl4RHPRetrohippocampal region3.84
2.89
Acsl4sAMYStriatum-like amygdalar nuclei1.93
1.72
Acsl4STRStriatum1.6
1.3
Acsl4STRdStriatum dorsal region1.81
1.47
Acsl4STRvStriatum ventral region1.06
0.7
Acsl4THThalamus3.71
3.49
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
ACSL4_HUMAN_438 15 438 452 MMLSGGAPLSPQTHR PRIDE
PAp00003167 19 246 264 GVMMHHSNLIAGMTGQCER Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved