AutismKB 2.0

Annotation Detail for PTK2B


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Basic Information Top
Gene Symbol:PTK2B ( CADTK,CAKB,FADK2,FAK2,PKB,PTK,PYK2,RAFTK )
Gene Full Name: PTK2B protein tyrosine kinase 2 beta
Band: 8p21.2
Quick LinksEntrez ID:2185; OMIM: 601212; Uniprot ID:FAK2_HUMAN; ENSEMBL ID: ENSG00000120899; HGNC ID: 9612
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body4 / 7076156
blastocyst0 / 623190 
fetus17 / 56401230
neonate1 / 3109732
infant0 / 236200 
juvenile4 / 5555671
adult93 / 193912147
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma1 / 1747557
breast (mammary gland) tumor1 / 9417810
cervical tumor0 / 343660 
chondrosarcoma4 / 8282348
colorectal tumor5 / 11424643
esophageal tumor0 / 172900 
gastrointestinal tumor41 / 119369343
germ cell tumor4 / 26384515
glioma2 / 10688318
head and neck tumor3 / 13630222
kidney tumor2 / 6895929
leukemia29 / 95842302
liver tumor1 / 9635910
lung tumor11 / 103127106
lymphoma19 / 71755264
non-neoplasia2 / 9725020
normal122 / 336030736
ovarian tumor5 / 7668265
pancreatic tumor2 / 10461619
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer1 / 1026809
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor2 / 9025722
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder1 / 2975733
blood27 / 123478218
bone0 / 716550 
bone marrow5 / 48801102
brain58 / 110098952
cervix0 / 481710 
connective tissue5 / 14925533
ear0 / 162120 
embryonic tissue4 / 21572218
esophagus0 / 202090 
eye6 / 21105428
heart0 / 896260 
intestine5 / 23447221
kidney4 / 21177718
larynx1 / 2414541
liver2 / 2077439
lung20 / 33697459
lymph14 / 44270316
lymph node20 / 91610218
mammary gland1 / 1532716
mouth0 / 670520 
muscle1 / 1077159
nerve0 / 157680 
ovary5 / 10205148
pancreas2 / 2148129
parathyroid0 / 205390 
pharynx1 / 4132824
pituitary gland0 / 165850 
placenta3 / 28082510
prostate2 / 18934510
salivary gland0 / 201550 
skin7 / 21057433
spleen3 / 5395255
stomach42 / 96619434
testis3 / 3304429
thymus16 / 81131197
thyroid2 / 4747342
tonsil6 / 16999352
trachea1 / 5241319
umbilical cord0 / 136800 
uterus3 / 23287812
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 203111_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts19
Adipocyte4.95
AdrenalCortex5.1
Adrenalgland4.15
Amygdala5.35
Appendix4.9
AtrioventricularNode3.7
BDCA4+_DentriticCells5.75
Bonemarrow4.95
BronchialEpithelialCells4.8
CD105+_Endothelial5
CD14+_Monocytes7.2
CD19+_BCells(neg._sel.)12.5
CD33+_Myeloid8.95
CD34+6.4
CD4+_Tcells7.1
CD56+_NKCells6.15
CD71+_EarlyErythroid5
CD8+_Tcells6.5
CardiacMyocytes6.3
Caudatenucleus4.45
Cerebellum11.8
CerebellumPeduncles6.15
CiliaryGanglion3.45
CingulateCortex5.9
Colorectaladenocarcinoma5
DorsalRootGanglion3.7
FetalThyroid4.8
Fetalbrain4.85
Fetalliver4.15
Fetallung4
GlobusPallidus3.7
Heart6.55
Hypothalamus5.3
Kidney3.95
Leukemia_chronicMyelogenousK-5624.25
Leukemia_promyelocytic-HL-604.45
Leukemialymphoblastic(MOLT-4)4
Liver6.45
Lung5.2
Lymphnode4.3
Lymphoma_burkitts(Daudi)6.35
Lymphoma_burkitts(Raji)10.85
MedullaOblongata6.7
OccipitalLobe4.5
OlfactoryBulb3.9
Ovary3.25
Pancreas4
PancreaticIslet5.35
ParietalLobe5.8
Pituitary5.75
Placenta5
Pons4.85
PrefrontalCortex8.45
Prostate5.8
Salivarygland4
SkeletalMuscle5.95
Skin3.75
SmoothMuscle5.65
Spinalcord5.2
SubthalamicNucleus4.8
SuperiorCervicalGanglion5.6
TemporalLobe8.15
Testis4
TestisGermCell4.15
TestisIntersitial4.2
TestisLeydigCell4.85
TestisSeminiferousTubule4.25
Thalamus5.05
Thymus4
Thyroid6.25
Tongue4.8
Tonsil4.85
Trachea4.15
TrigeminalGanglion4.8
Uterus4
UterusCorpus4.45
WholeBlood9.95
Wholebrain4.35
colon5.05
pineal_day6.18
pineal_night6.04
retina6
small_intestine4.85
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_16805_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala3.83 ± 0.75
Basal Forebrain3.2 ± 0.23
Basal Part of Pons3.42 ± 0.38
Cerebellar Cortex4.59 ± 0.41
Cerebellar Nuclei3.27 ± 0.41
Claustrum3.45 ± 0.79
Epithalamus3.04 ± 0.68
Frontal Lobe4.08 ± 0.71
Globus Pallidus2.08 ± 0.95
Hypothalamus3.07 ± 0.84
Insula4.21 ± 0.94
Limbic Lobe4.43 ± 0.77
Mesencephalon3.7 ± 0.82
Myelencephalon3.87 ± 0.65
Occipital Lobe4.03 ± 0.81
Parietal Lobe4.11 ± 0.67
Pontine Tegmentum3.96 ± 0.68
Striatum3.34 ± 0.73
Subthalamus3.33 ± 0.73
Temporal Lobe4.03 ± 0.64
Thalamus4.17 ± 0.53
White Matter1.93 ± 0.8
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Ptk2bCBCerebellum4.77
5.92
Ptk2bCTXCerebral cortex100
100
Ptk2bHIPHippocampal region100
100
Ptk2bHPFHippocampal formation100
100
Ptk2bHYHypothalamus5.83
6.15
Ptk2bLSXLateral septal complex100
100
Ptk2bMBMidbrain7.39
8.61
Ptk2bMYMedulla4.09
5.04
Ptk2bOLFOlfactory bulb100
100
Ptk2bPPons2.09
2.62
Ptk2bPALPallidum24.77
32.01
Ptk2bRHPRetrohippocampal region100
100
Ptk2bsAMYStriatum-like amygdalar nuclei63.43
79.14
Ptk2bSTRStriatum100
100
Ptk2bSTRdStriatum dorsal region100
100
Ptk2bSTRvStriatum ventral region100
100
Ptk2bTHThalamus51.25
58.83
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00009578 25 310 334 CLPLEEGQAVLQLGIEGAPQALSIK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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