AutismKB 2.0

Annotation Detail for FASN


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Basic Information Top
Gene Symbol:FASN ( FAS,MGC14367,MGC15706,OA-519,SDR27X1 )
Gene Full Name: fatty acid synthase
Band: 17q25.3
Quick LinksEntrez ID:2194; OMIM: 600212; Uniprot ID:FAS_HUMAN; ENSEMBL ID: ENSG00000169710; HGNC ID: 3594
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body18 / 70761254
blastocyst22 / 62319353
fetus28 / 56401249
neonate0 / 310970 
infant1 / 2362042
juvenile5 / 5555689
adult538 / 1939121277
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma4 / 17475228
breast (mammary gland) tumor43 / 94178456
cervical tumor10 / 34366290
chondrosarcoma4 / 8282348
colorectal tumor22 / 114246192
esophageal tumor0 / 172900 
gastrointestinal tumor14 / 119369117
germ cell tumor97 / 263845367
glioma22 / 106883205
head and neck tumor6 / 13630244
kidney tumor5 / 6895972
leukemia4 / 9584241
liver tumor36 / 96359373
lung tumor60 / 103127581
lymphoma26 / 71755362
non-neoplasia1 / 9725010
normal349 / 3360307103
ovarian tumor8 / 76682104
pancreatic tumor20 / 104616191
primitive neuroectodermal tumor of the CNS64 / 125680509
prostate cancer316 / 1026803077
retinoblastoma37 / 46356798
skin tumor114 / 124949912
soft tissue/muscle tissue tumor26 / 125191207
uterine tumor13 / 90257144
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue10 / 13106763
adrenal gland2 / 3319760
ascites6 / 40015149
bladder6 / 29757201
blood4 / 12347832
bone11 / 71655153
bone marrow0 / 488010 
brain119 / 1100989108
cervix12 / 48171249
connective tissue5 / 14925533
ear0 / 162120 
embryonic tissue48 / 215722222
esophagus0 / 202090 
eye70 / 211054331
heart1 / 8962611
intestine38 / 234472162
kidney7 / 21177733
larynx1 / 2414541
liver40 / 207743192
lung80 / 336974237
lymph19 / 44270429
lymph node11 / 91610120
mammary gland62 / 153271404
mouth0 / 670520 
muscle21 / 107715194
nerve6 / 15768380
ovary36 / 102051352
pancreas26 / 214812121
parathyroid0 / 205390 
pharynx1 / 4132824
pituitary gland1 / 1658560
placenta44 / 280825156
prostate330 / 1893451742
salivary gland4 / 20155198
skin196 / 210574930
spleen1 / 5395218
stomach4 / 9661941
testis10 / 33044230
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus25 / 232878107
vascular1 / 5178019
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 212218_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts579.6
Adipocyte7477.55
AdrenalCortex96.05
Adrenalgland101.8
Amygdala398.9
Appendix53.25
AtrioventricularNode43.9
BDCA4+_DentriticCells25.65
Bonemarrow27.7
BronchialEpithelialCells792.8
CD105+_Endothelial48.1
CD14+_Monocytes22.95
CD19+_BCells(neg._sel.)23.8
CD33+_Myeloid28.15
CD34+41.45
CD4+_Tcells24.2
CD56+_NKCells27.25
CD71+_EarlyErythroid23
CD8+_Tcells23.45
CardiacMyocytes26.8
Caudatenucleus106.55
Cerebellum139.6
CerebellumPeduncles106.4
CiliaryGanglion111.6
CingulateCortex83
Colorectaladenocarcinoma339.05
DorsalRootGanglion55.1
FetalThyroid46.35
Fetalbrain177.55
Fetalliver102.65
Fetallung156.8
GlobusPallidus32.25
Heart32.2
Hypothalamus155.15
Kidney18.25
Leukemia_chronicMyelogenousK-562536.75
Leukemia_promyelocytic-HL-60218.35
Leukemialymphoblastic(MOLT-4)465.65
Liver2769.9
Lung917.1
Lymphnode32.55
Lymphoma_burkitts(Daudi)56.75
Lymphoma_burkitts(Raji)760.15
MedullaOblongata89.2
OccipitalLobe77.45
OlfactoryBulb89.55
Ovary16.35
Pancreas22.05
PancreaticIslet23.8
ParietalLobe87.05
Pituitary26.55
Placenta99.15
Pons80.05
PrefrontalCortex331.55
Prostate1201.15
Salivarygland19.7
SkeletalMuscle34.25
Skin68.65
SmoothMuscle32
Spinalcord107.4
SubthalamicNucleus115.25
SuperiorCervicalGanglion73.4
TemporalLobe70.5
Testis19.35
TestisGermCell56.15
TestisIntersitial27
TestisLeydigCell29.05
TestisSeminiferousTubule34.95
Thalamus51.65
Thymus95.65
Thyroid65.6
Tongue59.7
Tonsil22.05
Trachea33.8
TrigeminalGanglion88.6
Uterus18.35
UterusCorpus20.2
WholeBlood24.5
Wholebrain114.7
colon39.9
pineal_day54.94
pineal_night37.54
retina119
small_intestine21.75
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_14284_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala2.42 ± 0.73
Basal Forebrain2.09 ± 0.52
Basal Part of Pons1.95 ± 0.54
Cerebellar Cortex2.34 ± 0.53
Cerebellar Nuclei2.12 ± 0.6
Claustrum2.4 ± 0.79
Epithalamus1.96 ± 0.69
Frontal Lobe2.12 ± 0.69
Globus Pallidus1.74 ± 0.8
Hypothalamus1.96 ± 0.76
Insula1.53 ± 0.66
Limbic Lobe2.19 ± 0.65
Mesencephalon2.23 ± 0.69
Myelencephalon2.2 ± 0.7
Occipital Lobe2.11 ± 0.75
Parietal Lobe2.21 ± 0.66
Pontine Tegmentum2.23 ± 0.64
Striatum2.16 ± 0.6
Subthalamus2.06 ± 0.77
Temporal Lobe2.29 ± 0.71
Thalamus2.15 ± 0.59
White Matter2.35 ± 0.49
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
FasnCBCerebellum61.87
82.89
FasnCTXCerebral cortex100
100
FasnHIPHippocampal region79.05
100
FasnHPFHippocampal formation88.21
100
FasnHYHypothalamus86.59
80.67
FasnLSXLateral septal complex45.08
37.29
FasnMBMidbrain85.29
89.38
FasnMYMedulla85.73
100
FasnOLFOlfactory bulb97.07
98.54
FasnPPons92.3
100
FasnPALPallidum76.11
78.25
FasnRHPRetrohippocampal region96.81
99.83
FasnsAMYStriatum-like amygdalar nuclei92.53
88.02
FasnSTRStriatum70.7
60.06
FasnSTRdStriatum dorsal region71.81
62.25
FasnSTRvStriatum ventral region62.99
48.3
FasnTHThalamus88.82
88.41
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
FAS_HUMAN_0 0 0 0 ALGLGVEQLPVVFEDVVLHQATILPK PRIDE
FAS_HUMAN_0 0 0 0 DLVEAVAHILGIR PRIDE
FAS_HUMAN_0 0 0 0 TLLEGSGLESIISIIHSSLAEPR PRIDE
FAS_HUMAN_1 12 1 12 MEEVVIAGMSGK PRIDE
FAS_HUMAN_1051 12 1051 1062 VTAIHIDPATHR PRIDE
FAS_HUMAN_1053 11 1053 1063 TAIHIDPATHR PRIDE
FAS_HUMAN_1065 17 1065 1081 LYTLQDKAQVADVVVSR PRIDE
FAS_HUMAN_1072 10 1072 1081 AQVADVVVSR PRIDE
FAS_HUMAN_1085 19 1085 1103 VTVAGGVHISGLHTESAPR PRIDE
FAS_HUMAN_1131 11 1131 1141 AALQEELQLCK PRIDE
FAS_HUMAN_1158 13 1158 1170 MVVPGLDGAQIPR PRIDE
FAS_HUMAN_1158 22 1158 1179 MVVPGLDGAQIPRDPSQQELPR PRIDE
FAS_HUMAN_1159 13 1159 1171 MVVPGLDGAQIPR PRIDE
FAS_HUMAN_1171 9 1171 1179 DPSQQELPR PRIDE
FAS_HUMAN_1208 17 1208 1224 LPEDPLLSGLLDSPALK PRIDE
FAS_HUMAN_1209 17 1209 1225 LPEDPLLSGLLDSPALK PRIDE
FAS_HUMAN_1241 14 1241 1254 VVEVLAGHGHLYSR PRIDE
FAS_HUMAN_1255 20 1255 1274 IPGLLSPHPLLQLSYTATDR PRIDE
FAS_HUMAN_1337 12 1337 1348 EGGFLLLHTLLR PRIDE
FAS_HUMAN_1393 11 1393 1403 SFYGSTLFLCR PRIDE
FAS_HUMAN_1404 19 1404 1422 RPTPQDSPIFLPVDDTSFR PRIDE
FAS_HUMAN_1405 19 1405 1423 RPTPQDSPIFLPVDDTSFR PRIDE
FAS_HUMAN_1429 15 1429 1443 GILADEDSSRPVWLK PRIDE
FAS_HUMAN_1444 17 1444 1460 AINCATSGVVGLVNCLR PRIDE
FAS_HUMAN_1492 12 1492 1503 VLQGDLVMNVYR PRIDE
FAS_HUMAN_1495 12 1495 1506 VLQGDLVMNVYR PRIDE
FAS_HUMAN_1515 23 1515 1537 HFLLEEDKPEEPTAHAFVSTLTR PRIDE
FAS_HUMAN_1664 30 1664 1693 VRPGETLLIHSGSGGVGQAAIAIALSLGCR PRIDE
FAS_HUMAN_1711 13 1711 1723 FPQLDSTSFANSR PRIDE
FAS_HUMAN_1724 15 1724 1738 DTSFEQHVLWHTGGK PRIDE
FAS_HUMAN_1739 13 1739 1751 GVDLVLNSLAEEK PRIDE
FAS_HUMAN_1765 22 1765 1786 FLEIGKFDLSQNHPLGMAIFLK PRIDE
FAS_HUMAN_1771 16 1771 1786 FDLSQNHPLGMAIFLK PRIDE
FAS_HUMAN_1851 15 1851 1865 VVVQVLAEEPEAVLK PRIDE
FAS_HUMAN_1976 19 1976 1994 DGLLENQTPEFFQDVCKPK PRIDE
FAS_HUMAN_2125 13 2125 2137 DLVEAVAHILGIR PRIDE
FAS_HUMAN_2206 14 2206 2219 EDGLAQQQTQLNLR PRIDE
FAS_HUMAN_2220 13 2220 2232 SLLVNPEGPTLMR PRIDE
FAS_HUMAN_2221 13 2221 2233 SLLVNPEGPTLMR PRIDE
FAS_HUMAN_2233 30 2233 2262 LNSVQSSERPLFLVHPIEGSTTVFHSLASR PRIDE
FAS_HUMAN_224 12 224 235 SEGVVAVLLTKK PRIDE
FAS_HUMAN_2243 21 2243 2263 PLFLVHPIEGSTTVFHSLASR PRIDE
FAS_HUMAN_2263 12 2263 2274 LSIPTYGLQCTR PRIDE
FAS_HUMAN_2275 19 2275 2293 AAPLDSIHSLAAYYIDCIR PRIDE
FAS_HUMAN_2382 14 2382 2395 VLEALLPLKGLEER PRIDE
FAS_HUMAN_2396 10 2396 2405 VAAAVDLIIK PRIDE
FAS_HUMAN_2408 8 2408 2415 QELSFAAR PRIDE
FAS_HUMAN_2439 9 2439 2447 YHGNVMLLR PRIDE
FAS_HUMAN_2482 23 2482 2504 TLLEGSGLESIISIIHSSLAEPR PRIDE
FAS_HUMAN_274 24 274 297 SLYQSAGVAPESFEYIEAHGTGTK PRIDE
FAS_HUMAN_326 17 326 342 SNMGHPEPASGLAALAK PRIDE
FAS_HUMAN_343 30 343 372 VLLSLEHGLWAPNLHFHSPNPEIPALLDGR PRIDE
FAS_HUMAN_373 11 373 383 LQVVDQPLPVR PRIDE
FAS_HUMAN_41 8 41 48 AGLYGLPR PRIDE
FAS_HUMAN_430 14 430 443 TPEAVQKLLEQGLR PRIDE
FAS_HUMAN_443 25 443 467 HSQDLAFLSMLNDIAAVPATAMPFR PRIDE
FAS_HUMAN_444 25 444 468 HSQDLAFLSMLNDIAAVPATAMPFR PRIDE
FAS_HUMAN_455 14 455 468 NDIAAVPATAMPFR PRIDE
FAS_HUMAN_51 9 51 59 SGKLKDLSR PRIDE
FAS_HUMAN_55 15 55 69 DLSRFDASFFGVHPK PRIDE
FAS_HUMAN_59 11 59 69 FDASFFGVHPK PRIDE
FAS_HUMAN_611 20 611 630 EAHLPPGAMAAVGLSWEECK PRIDE
FAS_HUMAN_645 22 645 666 SKDTVTISGPQAPVFEFVEQLR PRIDE
FAS_HUMAN_646 21 646 666 DTVTISGPQAPVFEFVEQLRK PRIDE
FAS_HUMAN_676 23 676 698 TGGMAFHSYFMEAIAPPLLQELK PRIDE
FAS_HUMAN_71 10 71 80 QAHTMDPQLR PRIDE
FAS_HUMAN_711 17 711 727 WLSTSIPEAQWHSSLAR PRIDE
FAS_HUMAN_790 12 790 801 DNLEFFLAGIGR PRIDE
FAS_HUMAN_802 23 802 824 LHLSGIDANPNALFPPVEFPAPR PRIDE
FAS_HUMAN_825 10 825 834 GTPLISPLIK PRIDE
FAS_HUMAN_883 14 883 896 VLFPATGYLSIVWK PRIDE
FAS_HUMAN_901 26 901 926 ALGLGVEQLPVVFEDVVLHQATILPK PRIDE
FAS_HUMAN_927 9 927 935 TGTVSLEVR PRIDE
FAS_HUMAN_957 10 957 966 VYQWDDPDPR PRIDE
FAS_HUMAN_967 25 967 991 LFDHPESPTPNPTEPLFLAQAEVYK PRIDE
FAS_HUMAN_967 28 967 994 LFDHPESPTPNPTEPLFLAQAEVYKELR PRIDE
PAp00000169 11 1132 1142 AALQEELQLCK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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