AutismKB 2.0

Annotation Detail for SCUBE3


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Basic Information Top
Gene Symbol:SCUBE3 ( CEGF3,DKFZp686B09105,DKFZp686B1223,DKFZp686D20108,FLJ34743 )
Gene Full Name: signal peptide, CUB domain, EGF-like 3
Band: 6p21.3
Quick LinksEntrez ID:222663; OMIM: NA; Uniprot ID:SCUB3_HUMAN; ENSEMBL ID: ENSG00000146197; HGNC ID: 13655
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body8 / 70761113
blastocyst0 / 623190 
fetus3 / 5640125
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult34 / 193912117
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor1 / 9417810
cervical tumor0 / 343660 
chondrosarcoma3 / 8282336
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor5 / 26384518
glioma0 / 1068830 
head and neck tumor2 / 13630214
kidney tumor0 / 689590 
leukemia0 / 958420 
liver tumor0 / 963590 
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia9 / 9725092
normal66 / 336030719
ovarian tumor7 / 7668291
pancreatic tumor3 / 10461628
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor2 / 12494916
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor1 / 9025711
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland1 / 3319730
ascites0 / 400150 
bladder0 / 297570 
blood0 / 1234780 
bone4 / 7165555
bone marrow1 / 4880120
brain4 / 11009893
cervix0 / 481710 
connective tissue11 / 14925573
ear0 / 162120 
embryonic tissue10 / 21572246
esophagus0 / 202090 
eye6 / 21105428
heart0 / 896260 
intestine1 / 2344724
kidney12 / 21177756
larynx0 / 241450 
liver3 / 20774314
lung25 / 33697474
lymph0 / 442700 
lymph node0 / 916100 
mammary gland3 / 15327119
mouth1 / 6705214
muscle2 / 10771518
nerve0 / 157680 
ovary7 / 10205168
pancreas3 / 21481213
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta2 / 2808257
prostate2 / 18934510
salivary gland0 / 201550 
skin6 / 21057428
spleen0 / 539520 
stomach2 / 9661920
testis9 / 33044227
thymus0 / 811310 
thyroid5 / 47473105
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus1 / 2328784
vascular2 / 5178038
Microarray in BioGPS Top
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_11034_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala2.02 ± 1
Basal Forebrain1.44 ± 0.19
Basal Part of Pons1.18 ± 0.38
Cerebellar Cortex1.41 ± 0.76
Cerebellar Nuclei1.8 ± 0.76
Claustrum2.42 ± 0.85
Epithalamus1.39 ± 0.72
Frontal Lobe1.46 ± 0.65
Globus Pallidus2 ± 0.33
Hypothalamus1.58 ± 0.72
Insula1.26 ± 0.49
Limbic Lobe1.5 ± 0.56
Mesencephalon1.72 ± 0.66
Myelencephalon1.65 ± 0.65
Occipital Lobe1.51 ± 0.65
Parietal Lobe1.52 ± 0.68
Pontine Tegmentum1.59 ± 0.64
Striatum1.81 ± 0.61
Subthalamus1.64 ± 0.62
Temporal Lobe1.52 ± 0.68
Thalamus1.71 ± 0.61
White Matter1.91 ± 0.21
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Scube3CBCerebellum1.32
1.9
Scube3CTXCerebral cortex0.72
0.7
Scube3HIPHippocampal region1.19
1.34
Scube3HPFHippocampal formation1.05
1.06
Scube3HYHypothalamus0.2
0.23
Scube3LSXLateral septal complex0.26
0.4
Scube3MBMidbrain0.41
0.73
Scube3MYMedulla2.13
3.16
Scube3OLFOlfactory bulb3.02
2.4
Scube3PPons0.37
0.65
Scube3PALPallidum0.86
0.69
Scube3RHPRetrohippocampal region0.83
0.67
Scube3sAMYStriatum-like amygdalar nuclei0.68
0.51
Scube3STRStriatum5.28
3.28
Scube3STRdStriatum dorsal region5.61
3.49
Scube3STRvStriatum ventral region9.96
5.71
Scube3THThalamus1.05
1.24
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018