AutismKB 2.0

Annotation Detail for FEN1


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Basic Information Top
Gene Symbol:FEN1 ( FEN-1,MF1,RAD2 )
Gene Full Name: flap structure-specific endonuclease 1
Band: 11q12.2
Quick LinksEntrez ID:2237; OMIM: 600393; Uniprot ID:FEN1_HUMAN; ENSEMBL ID: ENSG00000168496; HGNC ID: 3650
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body4 / 7076156
blastocyst7 / 62319112
fetus38 / 56401267
neonate1 / 3109732
infant6 / 23620254
juvenile36 / 55556647
adult146 / 193912175
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor4 / 12794312
bladder carcinoma2 / 17475114
breast (mammary gland) tumor28 / 94178297
cervical tumor11 / 34366320
chondrosarcoma10 / 82823120
colorectal tumor16 / 114246140
esophageal tumor4 / 17290231
gastrointestinal tumor12 / 119369100
germ cell tumor48 / 263845181
glioma15 / 106883140
head and neck tumor2 / 13630214
kidney tumor6 / 6895987
leukemia21 / 95842219
liver tumor4 / 9635941
lung tumor48 / 103127465
lymphoma35 / 71755487
non-neoplasia4 / 9725041
normal166 / 336030749
ovarian tumor5 / 7668265
pancreatic tumor7 / 10461666
primitive neuroectodermal tumor of the CNS47 / 125680373
prostate cancer10 / 10268097
retinoblastoma33 / 46356711
skin tumor19 / 124949152
soft tissue/muscle tissue tumor19 / 125191151
uterine tumor9 / 9025799
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland5 / 33197150
ascites4 / 4001599
bladder6 / 29757201
blood18 / 123478145
bone7 / 7165597
bone marrow14 / 48801286
brain85 / 110098977
cervix12 / 48171249
connective tissue4 / 14925526
ear0 / 162120 
embryonic tissue19 / 21572288
esophagus4 / 20209197
eye36 / 211054170
heart4 / 8962644
intestine22 / 23447293
kidney22 / 211777103
larynx0 / 241450 
liver18 / 20774386
lung61 / 336974181
lymph19 / 44270429
lymph node8 / 9161087
mammary gland32 / 153271208
mouth1 / 6705214
muscle3 / 10771527
nerve0 / 157680 
ovary13 / 102051127
pancreas11 / 21481251
parathyroid0 / 205390 
pharynx2 / 4132848
pituitary gland0 / 165850 
placenta24 / 28082585
prostate11 / 18934558
salivary gland9 / 20155446
skin20 / 21057494
spleen2 / 5395237
stomach6 / 9661962
testis26 / 33044278
thymus4 / 8113149
thyroid1 / 4747321
tonsil4 / 16999235
trachea0 / 524130 
umbilical cord0 / 136800 
uterus29 / 232878124
vascular5 / 5178096
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 204767_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts850.65
Adipocyte9.3
AdrenalCortex11.8
Adrenalgland8.25
Amygdala17.4
Appendix10.45
AtrioventricularNode7.8
BDCA4+_DentriticCells92.15
Bonemarrow55.35
BronchialEpithelialCells30.9
CD105+_Endothelial1483.25
CD14+_Monocytes12
CD19+_BCells(neg._sel.)24.85
CD33+_Myeloid54.5
CD34+717.05
CD4+_Tcells10.5
CD56+_NKCells77.95
CD71+_EarlyErythroid629.15
CD8+_Tcells9.15
CardiacMyocytes39.05
Caudatenucleus8.1
Cerebellum12.45
CerebellumPeduncles14.3
CiliaryGanglion5.8
CingulateCortex11.6
Colorectaladenocarcinoma146.75
DorsalRootGanglion7.25
FetalThyroid9.2
Fetalbrain9.85
Fetalliver60.4
Fetallung8.4
GlobusPallidus7.55
Heart14.5
Hypothalamus13.85
Kidney8.7
Leukemia_chronicMyelogenousK-56287.9
Leukemia_promyelocytic-HL-6096.6
Leukemialymphoblastic(MOLT-4)138
Liver17.25
Lung11.25
Lymphnode9.75
Lymphoma_burkitts(Daudi)166.3
Lymphoma_burkitts(Raji)18.5
MedullaOblongata9.2
OccipitalLobe9
OlfactoryBulb7.35
Ovary7.55
Pancreas8.45
PancreaticIslet24.65
ParietalLobe9.5
Pituitary13.3
Placenta20.95
Pons9
PrefrontalCortex16.7
Prostate15.4
Salivarygland8.4
SkeletalMuscle11.7
Skin8.25
SmoothMuscle14.75
Spinalcord11.75
SubthalamicNucleus8.45
SuperiorCervicalGanglion13.1
TemporalLobe8.45
Testis23.2
TestisGermCell29.5
TestisIntersitial9.5
TestisLeydigCell10.1
TestisSeminiferousTubule9.5
Thalamus11.85
Thymus37.35
Thyroid11.95
Tongue10.7
Tonsil51.45
Trachea7.85
TrigeminalGanglion10.35
Uterus7.4
UterusCorpus8.6
WholeBlood11.75
Wholebrain15.1
colon15
pineal_day12.46
pineal_night11.4
retina17.6
small_intestine18
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_14228_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala2.97 ± 1
Basal Forebrain2.71 ± 0.94
Basal Part of Pons2.68 ± 0.51
Cerebellar Cortex2.27 ± 0.82
Cerebellar Nuclei2.47 ± 0.55
Claustrum3.06 ± 0.88
Epithalamus1.63 ± 1.18
Frontal Lobe2.47 ± 0.85
Globus Pallidus3.03 ± 0.86
Hypothalamus2.49 ± 0.79
Insula2.49 ± 0.76
Limbic Lobe2.7 ± 0.8
Mesencephalon2.6 ± 0.71
Myelencephalon2.55 ± 0.79
Occipital Lobe2.6 ± 1.05
Parietal Lobe2.43 ± 0.76
Pontine Tegmentum2.32 ± 0.83
Striatum2.61 ± 0.94
Subthalamus1.9 ± 0.67
Temporal Lobe2.39 ± 0.82
Thalamus2.23 ± 0.78
White Matter3.01 ± 0.54
Mouse Brain ISH
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
FEN1_HUMAN_1 19 1 19 MGIQGLAKLIADVAPSAIR PRIDE
FEN1_HUMAN_10 10 10 19 IADVAPSAIR PRIDE
FEN1_HUMAN_110 16 110 125 QLQQAQAAGAEQEVEK PRIDE
FEN1_HUMAN_2 15 2 16 GIQGLAKLIADVAPS PRIDE
FEN1_HUMAN_2 18 2 19 GIQGLAKLIADVAPSAIR PRIDE
FEN1_HUMAN_2 8 2 9 GIQGLAKL PRIDE
PAp00003423 26 143 168 HLLSLMGIPYLDAPSEAEASCAALVK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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