AutismKB 2.0

Annotation Detail for FGA


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Basic Information Top
Gene Symbol:FGA ( Fib2,MGC119422,MGC119423,MGC119425 )
Gene Full Name: fibrinogen alpha chain
Band: 4q31.3
Quick LinksEntrez ID:2243; OMIM: 134820; Uniprot ID:FIBA_HUMAN; ENSEMBL ID: ENSG00000171560; HGNC ID: 3661
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body1 / 7076114
blastocyst0 / 623190 
fetus305 / 564012540
neonate0 / 310970 
infant0 / 236200 
juvenile9 / 55556161
adult376 / 1939121193
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma1 / 8282312
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor2 / 11936916
germ cell tumor2 / 2638457
glioma0 / 1068830 
head and neck tumor0 / 1363020 
kidney tumor1 / 6895914
leukemia47 / 95842490
liver tumor53 / 96359550
lung tumor1 / 1031279
lymphoma1 / 7175513
non-neoplasia0 / 972500 
normal904 / 3360307269
ovarian tumor0 / 766820 
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor1 / 9025711
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder6 / 29757201
blood47 / 123478380
bone0 / 716550 
bone marrow0 / 488010 
brain2 / 11009891
cervix0 / 481710 
connective tissue1 / 1492556
ear0 / 162120 
embryonic tissue1 / 2157224
esophagus0 / 202090 
eye0 / 2110540 
heart20 / 89626223
intestine0 / 2344720 
kidney4 / 21177718
larynx0 / 241450 
liver826 / 2077433976
lung10 / 33697429
lymph1 / 4427022
lymph node0 / 916100 
mammary gland20 / 153271130
mouth0 / 670520 
muscle4 / 10771537
nerve0 / 157680 
ovary0 / 1020510 
pancreas2 / 2148129
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta2 / 2808257
prostate0 / 1893450 
salivary gland0 / 201550 
skin0 / 2105740 
spleen18 / 53952333
stomach2 / 9661920
testis9 / 33044227
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus3 / 23287812
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 205649_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts7.55
Adipocyte6.65
AdrenalCortex8.75
Adrenalgland6.25
Amygdala6.85
Appendix11.15
AtrioventricularNode6.5
BDCA4+_DentriticCells6.75
Bonemarrow7.65
BronchialEpithelialCells6.55
CD105+_Endothelial6.8
CD14+_Monocytes7.35
CD19+_BCells(neg._sel.)7.05
CD33+_Myeloid8.75
CD34+8.3
CD4+_Tcells6.95
CD56+_NKCells7.6
CD71+_EarlyErythroid6.65
CD8+_Tcells6.15
CardiacMyocytes11.05
Caudatenucleus6.2
Cerebellum5.7
CerebellumPeduncles8.25
CiliaryGanglion7.45
CingulateCortex7.25
Colorectaladenocarcinoma6.8
DorsalRootGanglion6.2
FetalThyroid7.05
Fetalbrain6.55
Fetalliver3281
Fetallung121.5
GlobusPallidus5.6
Heart11.35
Hypothalamus7.05
Kidney6.2
Leukemia_chronicMyelogenousK-5626.2
Leukemia_promyelocytic-HL-606
Leukemialymphoblastic(MOLT-4)5.25
Liver349.25
Lung7.4
Lymphnode5.6
Lymphoma_burkitts(Daudi)9.05
Lymphoma_burkitts(Raji)11.25
MedullaOblongata6.15
OccipitalLobe6.05
OlfactoryBulb5.35
Ovary7.2
Pancreas6.65
PancreaticIslet11.4
ParietalLobe7.8
Pituitary8.05
Placenta6.8
Pons7.2
PrefrontalCortex8.05
Prostate7.8
Salivarygland5.8
SkeletalMuscle10.35
Skin6.4
SmoothMuscle7.6
Spinalcord7.25
SubthalamicNucleus6.7
SuperiorCervicalGanglion14.3
TemporalLobe6.7
Testis5.9
TestisGermCell5.45
TestisIntersitial6.5
TestisLeydigCell7.85
TestisSeminiferousTubule5.9
Thalamus7.15
Thymus5.15
Thyroid8.2
Tongue10
Tonsil6.85
Trachea5.7
TrigeminalGanglion9.15
Uterus5.4
UterusCorpus7.1
WholeBlood7.4
Wholebrain5.4
colon6.95
pineal_day8.4
pineal_night8.28
retina8.375
small_intestine6.55
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P44274
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala1.97 ± 0.99
Basal Forebrain1.52 ± 0.19
Basal Part of Pons1.27 ± 0.38
Cerebellar Cortex1.36 ± 0.68
Cerebellar Nuclei1.8 ± 0.71
Claustrum2.38 ± 0.81
Epithalamus1.26 ± 0.68
Frontal Lobe1.38 ± 0.57
Globus Pallidus2.19 ± 0.36
Hypothalamus1.61 ± 0.65
Insula1.45 ± 0.53
Limbic Lobe1.53 ± 0.6
Mesencephalon1.69 ± 0.67
Myelencephalon1.56 ± 0.66
Occipital Lobe1.55 ± 0.57
Parietal Lobe1.51 ± 0.61
Pontine Tegmentum1.59 ± 0.67
Striatum1.73 ± 0.5
Subthalamus1.68 ± 0.62
Temporal Lobe1.45 ± 0.65
Thalamus1.51 ± 0.56
White Matter2.16 ± 0.34
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
FgaCBCerebellum27.59
39.31
FgaCTXCerebral cortex100
100
FgaHIPHippocampal region73.28
100
FgaHPFHippocampal formation75.32
100
FgaHYHypothalamus48.26
35.32
FgaLSXLateral septal complex80.5
58.64
FgaMBMidbrain46.44
41.66
FgaMYMedulla25.51
28.24
FgaOLFOlfactory bulb97.77
92.59
FgaPPons34.19
35.78
FgaPALPallidum68.06
57.73
FgaRHPRetrohippocampal region79.72
74.51
FgasAMYStriatum-like amygdalar nuclei100
96.09
FgaSTRStriatum100
83.59
FgaSTRdStriatum dorsal region100
84.64
FgaSTRvStriatum ventral region100
85.7
FgaTHThalamus80.14
64.58
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00024587 21 631 651 DCDDVLQTHPSGTQSGIFNIK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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