AutismKB 2.0

Annotation Detail for FGB


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Basic Information Top
Gene Symbol:FGB ( MGC104327,MGC120405 )
Gene Full Name: fibrinogen beta chain
Band: 4q31.3
Quick LinksEntrez ID:2244; OMIM: 134830; Uniprot ID:FIBB_HUMAN; ENSEMBL ID: ENSG00000171564; HGNC ID: 3662
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body2 / 7076128
blastocyst0 / 623190 
fetus411 / 564012728
neonate0 / 310970 
infant0 / 236200 
juvenile8 / 55556143
adult471 / 1939121242
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor1 / 3436629
chondrosarcoma0 / 828230 
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor14 / 26384553
glioma0 / 1068830 
head and neck tumor1 / 1363027
kidney tumor2 / 6895929
leukemia83 / 95842866
liver tumor150 / 963591556
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia0 / 972500 
normal1008 / 3360307299
ovarian tumor0 / 766820 
pancreatic tumor2 / 10461619
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor2 / 9025722
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder1 / 2975733
blood83 / 123478672
bone0 / 716550 
bone marrow0 / 488010 
brain3 / 11009892
cervix1 / 4817120
connective tissue0 / 1492550 
ear0 / 162120 
embryonic tissue3 / 21572213
esophagus0 / 202090 
eye2 / 2110549
heart34 / 89626379
intestine2 / 2344728
kidney17 / 21177780
larynx0 / 241450 
liver1005 / 2077434837
lung8 / 33697423
lymph0 / 442700 
lymph node0 / 916100 
mammary gland29 / 153271189
mouth0 / 670520 
muscle10 / 10771592
nerve0 / 157680 
ovary0 / 1020510 
pancreas2 / 2148129
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta8 / 28082528
prostate0 / 1893450 
salivary gland0 / 201550 
skin0 / 2105740 
spleen3 / 5395255
stomach0 / 966190 
testis3 / 3304429
thymus0 / 811310 
thyroid1 / 4747321
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus2 / 2328788
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 204988_at
Cell line Expression level Expression bar
721_B_lymphoblasts8.6
Adipocyte8.55
AdrenalCortex12.6
Adrenalgland7.95
Amygdala8.3
Appendix11.15
AtrioventricularNode11.15
BDCA4+_DentriticCells8.4
Bonemarrow9.45
BronchialEpithelialCells8.15
CD105+_Endothelial8.45
CD14+_Monocytes9.15
CD19+_BCells(neg._sel.)8.7
CD33+_Myeloid10.75
CD34+10.2
CD4+_Tcells8.8
CD56+_NKCells11.05
CD71+_EarlyErythroid8.3
CD8+_Tcells7.65
CardiacMyocytes12.7
Caudatenucleus7.8
Cerebellum7.1
CerebellumPeduncles20.5
CiliaryGanglion9.2
CingulateCortex10.35
Colorectaladenocarcinoma8.3
DorsalRootGanglion8.75
FetalThyroid10.95
Fetalbrain8.25
Fetalliver6415.4
Fetallung1068.15
GlobusPallidus7.35
Heart11.95
Hypothalamus9.15
Kidney8.4
Leukemia_chronicMyelogenousK-5627.65
Leukemia_promyelocytic-HL-607.5
Leukemialymphoblastic(MOLT-4)6.7
Liver2343.05
Lung9.2
Lymphnode7.05
Lymphoma_burkitts(Daudi)11.65
Lymphoma_burkitts(Raji)12.8
MedullaOblongata7.75
OccipitalLobe7.65
OlfactoryBulb6.6
Ovary6.9
Pancreas7.1
PancreaticIslet101
ParietalLobe10.2
Pituitary10.2
Placenta8.1
Pons8.5
PrefrontalCortex10.2
Prostate11.6
Salivarygland7.4
SkeletalMuscle12.95
Skin9
SmoothMuscle9.5
Spinalcord9.1
SubthalamicNucleus9
SuperiorCervicalGanglion25.65
TemporalLobe8.2
Testis7.3
TestisGermCell6.8
TestisIntersitial7.3
TestisLeydigCell9.25
TestisSeminiferousTubule7.35
Thalamus13.7
Thymus6.2
Thyroid9.65
Tongue9.2
Tonsil8.65
Trachea7.1
TrigeminalGanglion9.55
Uterus6.7
UterusCorpus8.35
WholeBlood8.9
Wholebrain6.65
colon8.25
pineal_day10.24
pineal_night10.02
retina10.2
small_intestine7.85
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P550411
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala2.26 ± 1.04
Basal Forebrain1.82 ± 0.22
Basal Part of Pons1.49 ± 0.44
Cerebellar Cortex1.75 ± 0.73
Cerebellar Nuclei2.11 ± 0.76
Claustrum2.71 ± 0.76
Epithalamus1.46 ± 0.67
Frontal Lobe1.77 ± 0.67
Globus Pallidus2.21 ± 0.44
Hypothalamus1.9 ± 0.58
Insula1.74 ± 0.61
Limbic Lobe1.81 ± 0.61
Mesencephalon2 ± 0.64
Myelencephalon1.87 ± 0.72
Occipital Lobe2.06 ± 0.84
Parietal Lobe1.85 ± 0.78
Pontine Tegmentum1.86 ± 0.68
Striatum2.1 ± 0.73
Subthalamus1.97 ± 0.63
Temporal Lobe1.7 ± 0.65
Thalamus1.79 ± 0.64
White Matter2.07 ± 0.15
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
FgbCBCerebellum0.66
1.67
FgbCTXCerebral cortex0.64
0.61
FgbHIPHippocampal region0.9
0.77
FgbHPFHippocampal formation1.55
1.27
FgbHYHypothalamus0.19
0.28
FgbLSXLateral septal complex0.06
0.04
FgbMBMidbrain0.37
0.74
FgbMYMedulla0.71
1.66
FgbOLFOlfactory bulb2.08
1.53
FgbPPons1.07
2.1
FgbPALPallidum0.25
0.24
FgbRHPRetrohippocampal region2.76
2.05
FgbsAMYStriatum-like amygdalar nuclei0.02
0
FgbSTRStriatum0.26
0.22
FgbSTRdStriatum dorsal region0.31
0.21
FgbSTRvStriatum ventral region0.29
0.38
FgbTHThalamus0.23
0.42
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
FIBB_HUMAN_160 18 160 177 QVKDNENVVNEYSSELEK PRIDE
FIBB_HUMAN_160 36 160 195 QVKDNENVVNEYSSELEKHQLYIDETVNSNIPTNLR PRIDE
FIBB_HUMAN_163 15 163 177 DNENVVNEYSSELEK PRIDE
FIBB_HUMAN_163 33 163 195 DNENVVNEYSSELEKHQLYIDETVNSNIPTNLR PRIDE
FIBB_HUMAN_178 18 178 195 HQLYIDETVNSNIPTNLR PRIDE
FIBB_HUMAN_199 7 199 205 SILENLR PRIDE
FIBB_HUMAN_206 18 206 223 SKIQKLESDVSAQMEYCR PRIDE
FIBB_HUMAN_208 16 208 223 IQKLESDVSAQMEYCR PRIDE
FIBB_HUMAN_211 13 211 223 LESDVSAQMEYCR PRIDE
FIBB_HUMAN_224 15 224 238 TPCTVSCNIPVVSGK PRIDE
FIBB_HUMAN_224 22 224 245 TPCTVSCNIPVVSGKECEEIIR PRIDE
FIBB_HUMAN_224 23 224 246 TPCTVSCNIPVVSGKECEEIIRK PRIDE
FIBB_HUMAN_246 21 246 266 KGGETSEMYLIQPDSSVKPYR PRIDE
FIBB_HUMAN_247 20 247 266 GGETSEMYLIQPDSSVKPYR PRIDE
FIBB_HUMAN_267 18 267 284 VYCDMNTENGGWTVIQNR PRIDE
FIBB_HUMAN_294 19 294 312 KWDPYKQGFGNVATNTDGK PRIDE
FIBB_HUMAN_295 18 295 312 WDPYKQGFGNVATNTDGK PRIDE
FIBB_HUMAN_300 13 300 312 QGFGNVATNTDGK PRIDE
FIBB_HUMAN_313 15 313 327 NYCGLPGEYWLGNDK PRIDE
FIBB_HUMAN_313 21 313 333 NYCGLPGEYWLGNDKISQLTR PRIDE
FIBB_HUMAN_334 14 334 347 MGPTELLIEMEDWK PRIDE
FIBB_HUMAN_334 17 334 350 MGPTELLIEMEDWKGDK PRIDE
FIBB_HUMAN_334 19 334 352 MGPTELLIEMEDWKGDKVK PRIDE
FIBB_HUMAN_353 14 353 366 AHYGGFTVQNEANK PRIDE
FIBB_HUMAN_353 21 353 373 AHYGGFTVQNEANKYQISVNK PRIDE
FIBB_HUMAN_395 26 395 420 TMTIHNGMFFSTYDRDNDGWLTSDPR PRIDE
FIBB_HUMAN_410 11 410 420 DNDGWLTSDPR PRIDE
FIBB_HUMAN_421 15 421 435 KQCSKEDGGGWWYNR PRIDE
FIBB_HUMAN_426 10 426 435 EDGGGWWYNR PRIDE
FIBB_HUMAN_445 13 445 457 YYWGGQYTWDMAK PRIDE
FIBB_HUMAN_458 13 458 470 HGTDDGVVWMNWK PRIDE
FIBB_HUMAN_471 7 471 477 GSWYSMR PRIDE
FIBB_HUMAN_483 8 483 490 IRPFFPQQ PRIDE
FIBB_HUMAN_51 21 51 71 KREEAPSLRPAPPPISGGGYR PRIDE
FIBB_HUMAN_52 20 52 71 REEAPSLRPAPPPISGGGYR PRIDE
FIBB_HUMAN_53 19 53 71 EEAPSLRPAPPPISGGGYR PRIDE
FIBB_HUMAN_76 12 76 87 AKAAATQKKVER PRIDE
FIBB_HUMAN_87 37 87 123 KAPDAGGCLHADPDLGVLCPTGCQLQEALLQQERPIR PRIDE
PAp00000008 9 437 445 CHAANPNGR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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