AutismKB 2.0

Annotation Detail for FGF2


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Basic Information Top
Gene Symbol:FGF2 ( BFGF,FGFB,HBGF-2 )
Gene Full Name: fibroblast growth factor 2 (basic)
Band: 4q28.1
Quick LinksEntrez ID:2247; OMIM: 134920; Uniprot ID:FGF2_HUMAN; ENSEMBL ID: ENSG00000138685; HGNC ID: 3676
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body1 / 7076114
blastocyst4 / 6231964
fetus15 / 56401226
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult175 / 193912190
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma1 / 1747557
breast (mammary gland) tumor4 / 9417842
cervical tumor0 / 343660 
chondrosarcoma6 / 8282372
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor11 / 26384541
glioma4 / 10688337
head and neck tumor21 / 136302154
kidney tumor5 / 6895972
leukemia1 / 9584210
liver tumor4 / 9635941
lung tumor3 / 10312729
lymphoma0 / 717550 
non-neoplasia4 / 9725041
normal107 / 336030731
ovarian tumor2 / 7668226
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor19 / 125191151
uterine tumor1 / 9025711
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood0 / 1234780 
bone2 / 7165527
bone marrow1 / 4880120
brain14 / 110098912
cervix0 / 481710 
connective tissue25 / 149255167
ear2 / 16212123
embryonic tissue8 / 21572237
esophagus0 / 202090 
eye7 / 21105433
heart1 / 8962611
intestine1 / 2344724
kidney11 / 21177751
larynx0 / 241450 
liver4 / 20774319
lung7 / 33697420
lymph0 / 442700 
lymph node0 / 916100 
mammary gland6 / 15327139
mouth0 / 670520 
muscle2 / 10771518
nerve0 / 157680 
ovary3 / 10205129
pancreas4 / 21481218
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta1 / 2808253
prostate0 / 1893450 
salivary gland1 / 2015549
skin9 / 21057442
spleen0 / 539520 
stomach30 / 96619310
testis4 / 33044212
thymus0 / 811310 
thyroid21 / 47473442
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus75 / 232878322
vascular1 / 5178019
Microarray in BioGPS Top
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  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 204422_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts7.6
Adipocyte6.8
AdrenalCortex8.65
Adrenalgland6.45
Amygdala8.55
Appendix8.95
AtrioventricularNode8.75
BDCA4+_DentriticCells6.8
Bonemarrow8.15
BronchialEpithelialCells6.7
CD105+_Endothelial6.9
CD14+_Monocytes7.5
CD19+_BCells(neg._sel.)7.15
CD33+_Myeloid8.5
CD34+8.2
CD4+_Tcells6.95
CD56+_NKCells7.9
CD71+_EarlyErythroid6.75
CD8+_Tcells6.15
CardiacMyocytes12.45
Caudatenucleus6.35
Cerebellum5.85
CerebellumPeduncles9
CiliaryGanglion7.65
CingulateCortex7.55
Colorectaladenocarcinoma6.9
DorsalRootGanglion7.35
FetalThyroid7
Fetalbrain6.95
Fetalliver6.25
Fetallung5.3
GlobusPallidus5.85
Heart10.75
Hypothalamus8.15
Kidney6.4
Leukemia_chronicMyelogenousK-5626.4
Leukemia_promyelocytic-HL-606.05
Leukemialymphoblastic(MOLT-4)5.4
Liver10.45
Lung7.55
Lymphnode5.65
Lymphoma_burkitts(Daudi)9.35
Lymphoma_burkitts(Raji)10.75
MedullaOblongata6.35
OccipitalLobe6.55
OlfactoryBulb5.6
Ovary5.35
Pancreas6.2
PancreaticIslet7.65
ParietalLobe8.3
Pituitary8.15
Placenta6.85
Pons7
PrefrontalCortex11.9
Prostate8.1
Salivarygland6.1
SkeletalMuscle10.95
Skin8.05
SmoothMuscle308.95
Spinalcord12.2
SubthalamicNucleus7.05
SuperiorCervicalGanglion11.95
TemporalLobe10.35
Testis6
TestisGermCell5.45
TestisIntersitial6.05
TestisLeydigCell7.55
TestisSeminiferousTubule6
Thalamus7.35
Thymus5.2
Thyroid8.25
Tongue8.7
Tonsil6.95
Trachea5.8
TrigeminalGanglion10.65
Uterus11.3
UterusCorpus7.6
WholeBlood7.55
Wholebrain5.7
colon7
pineal_day11.86
pineal_night8.92
retina11.3
small_intestine6.65
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P155857
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala5.61 ± 0.46
Basal Forebrain5.96 ± 0.2
Basal Part of Pons5.98 ± 0.29
Cerebellar Cortex6.23 ± 0.22
Cerebellar Nuclei6 ± 0.33
Claustrum5.46 ± 0.63
Epithalamus6.37 ± 0.24
Frontal Lobe6.01 ± 0.37
Globus Pallidus6.13 ± 0.14
Hypothalamus6.06 ± 0.46
Insula6.05 ± 0.28
Limbic Lobe5.76 ± 0.43
Mesencephalon5.86 ± 0.47
Myelencephalon5.87 ± 0.39
Occipital Lobe5.9 ± 0.35
Parietal Lobe5.95 ± 0.4
Pontine Tegmentum5.98 ± 0.42
Striatum5.68 ± 0.36
Subthalamus5.59 ± 0.73
Temporal Lobe5.97 ± 0.32
Thalamus5.98 ± 0.28
White Matter6.06 ± 0.3
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Fgf2CBCerebellum12.68
13.36
Fgf2CTXCerebral cortex32.6
22.78
Fgf2HIPHippocampal region17.04
19.24
Fgf2HPFHippocampal formation18.46
17.49
Fgf2HYHypothalamus11.26
9.29
Fgf2LSXLateral septal complex0.23
0.17
Fgf2MBMidbrain13.05
11.65
Fgf2MYMedulla16.81
16.2
Fgf2OLFOlfactory bulb20.93
14.5
Fgf2PPons15.07
15.18
Fgf2PALPallidum10.23
8.78
Fgf2RHPRetrohippocampal region21.88
15.93
Fgf2sAMYStriatum-like amygdalar nuclei5.63
3.92
Fgf2STRStriatum9.27
6.31
Fgf2STRdStriatum dorsal region8.18
5.59
Fgf2STRvStriatum ventral region17.35
11.11
Fgf2THThalamus14.37
11.57
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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