AutismKB 2.0

Annotation Detail for FGFR4


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Basic Information Top
Gene Symbol:FGFR4 ( CD334,JTK2,MGC20292,TKF )
Gene Full Name: fibroblast growth factor receptor 4
Band: 5q35.2
Quick LinksEntrez ID:2264; OMIM: 134935; Uniprot ID:FGFR4_HUMAN; ENSEMBL ID: ENSG00000160867; HGNC ID: 3691
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body2 / 7076128
blastocyst5 / 6231980
fetus25 / 56401244
neonate0 / 310970 
infant0 / 236200 
juvenile3 / 5555653
adult40 / 193912120
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor2 / 12794156
bladder carcinoma0 / 174750 
breast (mammary gland) tumor2 / 9417821
cervical tumor0 / 343660 
chondrosarcoma2 / 8282324
colorectal tumor11 / 11424696
esophageal tumor0 / 172900 
gastrointestinal tumor4 / 11936933
germ cell tumor15 / 26384556
glioma0 / 1068830 
head and neck tumor0 / 1363020 
kidney tumor3 / 6895943
leukemia3 / 9584231
liver tumor16 / 96359166
lung tumor0 / 1031270 
lymphoma4 / 7175555
non-neoplasia1 / 9725010
normal74 / 336030722
ovarian tumor3 / 7668239
pancreatic tumor3 / 10461628
primitive neuroectodermal tumor of the CNS2 / 12568015
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor5 / 12494940
soft tissue/muscle tissue tumor40 / 125191319
uterine tumor2 / 9025722
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland2 / 3319760
ascites2 / 4001549
bladder0 / 297570 
blood2 / 12347816
bone0 / 716550 
bone marrow1 / 4880120
brain4 / 11009893
cervix0 / 481710 
connective tissue2 / 14925513
ear0 / 162120 
embryonic tissue8 / 21572237
esophagus0 / 202090 
eye1 / 2110544
heart4 / 8962644
intestine19 / 23447281
kidney9 / 21177742
larynx0 / 241450 
liver16 / 20774377
lung4 / 33697411
lymph4 / 4427090
lymph node0 / 916100 
mammary gland2 / 15327113
mouth3 / 6705244
muscle40 / 107715371
nerve1 / 1576863
ovary7 / 10205168
pancreas3 / 21481213
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta2 / 2808257
prostate0 / 1893450 
salivary gland0 / 201550 
skin5 / 21057423
spleen4 / 5395274
stomach1 / 9661910
testis6 / 33044218
thymus1 / 8113112
thyroid0 / 474730 
tonsil0 / 169990 
trachea1 / 5241319
umbilical cord0 / 136800 
uterus3 / 23287812
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 211237_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts4.95
Adipocyte3.9
AdrenalCortex5.7
Adrenalgland3.35
Amygdala4.1
Appendix4
AtrioventricularNode3.05
BDCA4+_DentriticCells4.3
Bonemarrow3.9
BronchialEpithelialCells3.9
CD105+_Endothelial4
CD14+_Monocytes4.2
CD19+_BCells(neg._sel.)4.2
CD33+_Myeloid5.05
CD34+5
CD4+_Tcells4.3
CD56+_NKCells4.7
CD71+_EarlyErythroid3.7
CD8+_Tcells3.8
CardiacMyocytes5.05
Caudatenucleus3.5
Cerebellum3.2
CerebellumPeduncles4.5
CiliaryGanglion2.75
CingulateCortex4.1
Colorectaladenocarcinoma3.95
DorsalRootGanglion3
FetalThyroid3.8
Fetalbrain3.95
Fetalliver5.05
Fetallung5.15
GlobusPallidus2.95
Heart5.05
Hypothalamus4.3
Kidney6.65
Leukemia_chronicMyelogenousK-5623.75
Leukemia_promyelocytic-HL-603.5
Leukemialymphoblastic(MOLT-4)3.2
Liver37.4
Lung12.15
Lymphnode3.4
Lymphoma_burkitts(Daudi)5.6
Lymphoma_burkitts(Raji)5.5
MedullaOblongata3.55
OccipitalLobe3.55
OlfactoryBulb3.1
Ovary2.6
Pancreas3.2
PancreaticIslet4.25
ParietalLobe4.2
Pituitary4.65
Placenta4.1
Pons3.75
PrefrontalCortex4.9
Prostate4.6
Salivarygland3.2
SkeletalMuscle4.75
Skin3.05
SmoothMuscle4.45
Spinalcord4.2
SubthalamicNucleus3.6
SuperiorCervicalGanglion4.55
TemporalLobe3.65
Testis3.4
TestisGermCell3.3
TestisIntersitial3.3
TestisLeydigCell3.9
TestisSeminiferousTubule3.4
Thalamus4
Thymus3.1
Thyroid4.95
Tongue3.9
Tonsil3.8
Trachea3.3
TrigeminalGanglion3.95
Uterus3.25
UterusCorpus3.5
WholeBlood4.3
Wholebrain3.35
colon3.95
pineal_day4.92
pineal_night4.82
retina4.75
small_intestine3.8
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_14698_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala2.24 ± 0.99
Basal Forebrain1.92 ± 0.17
Basal Part of Pons1.59 ± 0.63
Cerebellar Cortex1.93 ± 0.74
Cerebellar Nuclei2.15 ± 0.71
Claustrum2.75 ± 0.81
Epithalamus1.59 ± 0.63
Frontal Lobe1.68 ± 0.58
Globus Pallidus2.37 ± 0.46
Hypothalamus1.87 ± 0.61
Insula1.78 ± 0.56
Limbic Lobe1.85 ± 0.6
Mesencephalon2.05 ± 0.65
Myelencephalon1.92 ± 0.68
Occipital Lobe2.25 ± 0.89
Parietal Lobe1.91 ± 0.77
Pontine Tegmentum1.92 ± 0.63
Striatum1.95 ± 0.62
Subthalamus2.01 ± 0.6
Temporal Lobe1.78 ± 0.61
Thalamus1.89 ± 0.62
White Matter2.21 ± 0.21
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Fgfr4CBCerebellum8.85
7.33
Fgfr4CTXCerebral cortex3.22
2.17
Fgfr4HIPHippocampal region4.86
2.39
Fgfr4HPFHippocampal formation3.91
2.25
Fgfr4HYHypothalamus1.61
0.96
Fgfr4LSXLateral septal complex0.91
0.56
Fgfr4MBMidbrain1.81
1.58
Fgfr4MYMedulla12.61
10.04
Fgfr4OLFOlfactory bulb4.42
3.64
Fgfr4PPons6.4
5.31
Fgfr4PALPallidum0.63
0.6
Fgfr4RHPRetrohippocampal region2.08
1.86
Fgfr4sAMYStriatum-like amygdalar nuclei0.81
0.57
Fgfr4STRStriatum0.67
0.42
Fgfr4STRdStriatum dorsal region0.34
0.2
Fgfr4STRvStriatum ventral region1.89
1.11
Fgfr4THThalamus1.06
0.67
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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