AutismKB 2.0

Annotation Detail for FHL2


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:FHL2 ( AAG11,DRAL,FHL-2,SLIM-3,SLIM3 )
Gene Full Name: four and a half LIM domains 2
Band: 2q12.2
Quick LinksEntrez ID:2274; OMIM: 602633; Uniprot ID:FHL2_HUMAN; ENSEMBL ID: ENSG00000115641; HGNC ID: 3703
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body7 / 7076198
blastocyst0 / 623190 
fetus23 / 56401240
neonate2 / 3109764
infant0 / 236200 
juvenile2 / 5555635
adult146 / 193912175
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma2 / 17475114
breast (mammary gland) tumor7 / 9417874
cervical tumor0 / 343660 
chondrosarcoma5 / 8282360
colorectal tumor12 / 114246105
esophageal tumor1 / 1729057
gastrointestinal tumor20 / 119369167
germ cell tumor15 / 26384556
glioma3 / 10688328
head and neck tumor13 / 13630295
kidney tumor5 / 6895972
leukemia0 / 958420 
liver tumor7 / 9635972
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia1 / 9725010
normal167 / 336030749
ovarian tumor4 / 7668252
pancreatic tumor16 / 104616152
primitive neuroectodermal tumor of the CNS12 / 12568095
prostate cancer1 / 1026809
retinoblastoma3 / 4635664
skin tumor9 / 12494972
soft tissue/muscle tissue tumor8 / 12519163
uterine tumor15 / 90257166
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland1 / 3319730
ascites3 / 4001574
bladder1 / 2975733
blood1 / 1234788
bone8 / 71655111
bone marrow2 / 4880140
brain17 / 110098915
cervix4 / 4817183
connective tissue8 / 14925553
ear0 / 162120 
embryonic tissue8 / 21572237
esophagus1 / 2020949
eye18 / 21105485
heart33 / 89626368
intestine21 / 23447289
kidney11 / 21177751
larynx1 / 2414541
liver9 / 20774343
lung2 / 3369745
lymph0 / 442700 
lymph node5 / 9161054
mammary gland13 / 15327184
mouth5 / 6705274
muscle5 / 10771546
nerve0 / 157680 
ovary8 / 10205178
pancreas16 / 21481274
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland1 / 1658560
placenta45 / 280825160
prostate11 / 18934558
salivary gland5 / 20155248
skin15 / 21057471
spleen2 / 5395237
stomach23 / 96619238
testis11 / 33044233
thymus0 / 811310 
thyroid2 / 4747342
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord2 / 13680146
uterus20 / 23287885
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 202949_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts37.7
Adipocyte119.75
AdrenalCortex13.6
Adrenalgland61.4
Amygdala11.65
Appendix18
AtrioventricularNode11.5
BDCA4+_DentriticCells4.75
Bonemarrow19.45
BronchialEpithelialCells297.45
CD105+_Endothelial135.5
CD14+_Monocytes5.45
CD19+_BCells(neg._sel.)5.25
CD33+_Myeloid7.6
CD34+56.15
CD4+_Tcells5.25
CD56+_NKCells6.25
CD71+_EarlyErythroid248.25
CD8+_Tcells4.7
CardiacMyocytes307.4
Caudatenucleus7.25
Cerebellum6.35
CerebellumPeduncles7.75
CiliaryGanglion5.35
CingulateCortex11
Colorectaladenocarcinoma118.65
DorsalRootGanglion6.65
FetalThyroid18.15
Fetalbrain7.1
Fetalliver8.55
Fetallung10.45
GlobusPallidus8.2
Heart5392
Hypothalamus6.6
Kidney8.9
Leukemia_chronicMyelogenousK-56230
Leukemia_promyelocytic-HL-605.25
Leukemialymphoblastic(MOLT-4)6
Liver10.5
Lung41.45
Lymphnode11.05
Lymphoma_burkitts(Daudi)7.5
Lymphoma_burkitts(Raji)8.4
MedullaOblongata14.45
OccipitalLobe11.2
OlfactoryBulb14.5
Ovary781.95
Pancreas255.25
PancreaticIslet11.1
ParietalLobe9.65
Pituitary16.75
Placenta221.9
Pons7.6
PrefrontalCortex14.25
Prostate368.65
Salivarygland104.1
SkeletalMuscle11.55
Skin11
SmoothMuscle1544.85
Spinalcord8.75
SubthalamicNucleus7.9
SuperiorCervicalGanglion10.2
TemporalLobe11.1
Testis183.7
TestisGermCell230
TestisIntersitial65.3
TestisLeydigCell83.3
TestisSeminiferousTubule91.25
Thalamus7.15
Thymus41.15
Thyroid56.85
Tongue54.6
Tonsil7.9
Trachea52.3
TrigeminalGanglion25.85
Uterus352.45
UterusCorpus106.55
WholeBlood6.3
Wholebrain126.6
colon263.35
pineal_day8.36
pineal_night9.16
retina482.25
small_intestine275.3
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_12187_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala5.96 ± 0.9
Basal Forebrain4.56 ± 0.33
Basal Part of Pons5.01 ± 0.53
Cerebellar Cortex4.78 ± 0.58
Cerebellar Nuclei4.32 ± 0.57
Claustrum6.17 ± 0.49
Epithalamus4.65 ± 0.85
Frontal Lobe5.65 ± 0.74
Globus Pallidus3.22 ± 1.33
Hypothalamus4.19 ± 0.55
Insula5.56 ± 0.22
Limbic Lobe6.21 ± 0.97
Mesencephalon4.94 ± 0.79
Myelencephalon5.15 ± 0.65
Occipital Lobe5.36 ± 0.45
Parietal Lobe5.63 ± 0.77
Pontine Tegmentum5.27 ± 0.91
Striatum4.15 ± 1.43
Subthalamus4.59 ± 0.15
Temporal Lobe5.73 ± 0.54
Thalamus4.73 ± 0.87
White Matter3.08 ± 1.17
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Fhl2CBCerebellum6.62
9.22
Fhl2CTXCerebral cortex100
100
Fhl2HIPHippocampal region68.22
100
Fhl2HPFHippocampal formation66.6
92.38
Fhl2HYHypothalamus5.75
5.79
Fhl2LSXLateral septal complex6.2
7.02
Fhl2MBMidbrain7.31
8.89
Fhl2MYMedulla8.95
9.82
Fhl2OLFOlfactory bulb73.97
88.4
Fhl2PPons5.54
6.49
Fhl2PALPallidum7.66
7.43
Fhl2RHPRetrohippocampal region63.61
63.22
Fhl2sAMYStriatum-like amygdalar nuclei34.27
42.73
Fhl2STRStriatum15.5
16.94
Fhl2STRdStriatum dorsal region12.97
13.74
Fhl2STRvStriatum ventral region11.79
10.48
Fhl2THThalamus4.34
5.48
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
FHL2_HUMAN_119 13 119 131 GSSWHETCFICHR PRIDE
FHL2_HUMAN_145 12 145 156 DNQNFCVPCYEK PRIDE
FHL2_HUMAN_167 11 167 177 KPITTGGVTYR PRIDE
FHL2_HUMAN_184 9 184 192 ECFVCTACR PRIDE
FHL2_HUMAN_236 7 236 242 YISFEER PRIDE
FHL2_HUMAN_261 18 261 278 GFLTERDDILCPDCGKDI PRIDE
FHL2_HUMAN_262 18 262 279 GFLTERDDILCPDCGKDI PRIDE
FHL2_HUMAN_5 13 5 17 FDCHHCNESLFGK PRIDE
FHL2_HUMAN_73 11 73 83 NSLVDKPFAAK PRIDE
PAp00029723 13 5 17 FDCHHCNESLFGK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved