AutismKB 2.0

Annotation Detail for IKZF2


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Basic Information Top
Gene Symbol:IKZF2 ( HELIOS,MGC34330,ZNF1A2,ZNFN1A2 )
Gene Full Name: IKAROS family zinc finger 2 (Helios)
Band: 2q34
Quick LinksEntrez ID:22807; OMIM: 606234; Uniprot ID:IKZF2_HUMAN; ENSEMBL ID: ENSG00000030419; HGNC ID: 13177
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body2 / 7076128
blastocyst0 / 623190 
fetus10 / 56401217
neonate0 / 310970 
infant0 / 236200 
juvenile2 / 5555635
adult17 / 19391218
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma2 / 17475114
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor7 / 26384526
glioma0 / 1068830 
head and neck tumor7 / 13630251
kidney tumor0 / 689590 
leukemia4 / 9584241
liver tumor0 / 963590 
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia1 / 9725010
normal34 / 336030710
ovarian tumor0 / 766820 
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS1 / 1256807
prostate cancer1 / 1026809
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor1 / 1251917
uterine tumor1 / 9025711
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder2 / 2975767
blood1 / 1234788
bone0 / 716550 
bone marrow0 / 488010 
brain4 / 11009893
cervix0 / 481710 
connective tissue1 / 1492556
ear0 / 162120 
embryonic tissue2 / 2157229
esophagus0 / 202090 
eye4 / 21105418
heart2 / 8962622
intestine0 / 2344720 
kidney1 / 2117774
larynx0 / 241450 
liver0 / 2077430 
lung7 / 33697420
lymph0 / 442700 
lymph node2 / 9161021
mammary gland0 / 1532710 
mouth4 / 6705259
muscle3 / 10771527
nerve0 / 157680 
ovary0 / 1020510 
pancreas4 / 21481218
parathyroid0 / 205390 
pharynx2 / 4132848
pituitary gland0 / 165850 
placenta1 / 2808253
prostate4 / 18934521
salivary gland0 / 201550 
skin0 / 2105740 
spleen1 / 5395218
stomach0 / 966190 
testis1 / 3304423
thymus5 / 8113161
thyroid4 / 4747384
tonsil0 / 169990 
trachea2 / 5241338
umbilical cord0 / 136800 
uterus1 / 2328784
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 220567_at
Cell line Expression level Expression bar
721_B_lymphoblasts5.95
Adipocyte4.6
AdrenalCortex5.1
Adrenalgland4
Amygdala4.85
Appendix5.45
AtrioventricularNode3.55
BDCA4+_DentriticCells4.95
Bonemarrow4.8
BronchialEpithelialCells4.5
CD105+_Endothelial4.7
CD14+_Monocytes4.9
CD19+_BCells(neg._sel.)4.85
CD33+_Myeloid5.75
CD34+5.7
CD4+_Tcells5.05
CD56+_NKCells5.3
CD71+_EarlyErythroid4.5
CD8+_Tcells4.4
CardiacMyocytes6.45
Caudatenucleus4.2
Cerebellum3.75
CerebellumPeduncles5.35
CiliaryGanglion3.3
CingulateCortex4.75
Colorectaladenocarcinoma4.6
DorsalRootGanglion3.65
FetalThyroid4.9
Fetalbrain4.55
Fetalliver4.25
Fetallung3.7
GlobusPallidus3.5
Heart6.35
Hypothalamus5
Kidney3.95
Leukemia_chronicMyelogenousK-5624.15
Leukemia_promyelocytic-HL-604.05
Leukemialymphoblastic(MOLT-4)3.65
Liver6.25
Lung5
Lymphnode3.9
Lymphoma_burkitts(Daudi)6.05
Lymphoma_burkitts(Raji)6.65
MedullaOblongata4.25
OccipitalLobe4.15
OlfactoryBulb3.65
Ovary3.1
Pancreas3.75
PancreaticIslet4.9
ParietalLobe4.95
Pituitary5.5
Placenta4.8
Pons4.45
PrefrontalCortex5.7
Prostate5.45
Salivarygland3.8
SkeletalMuscle5.7
Skin3.85
SmoothMuscle5.2
Spinalcord4.9
SubthalamicNucleus4.35
SuperiorCervicalGanglion5.55
TemporalLobe4.35
Testis4
TestisGermCell3.85
TestisIntersitial3.8
TestisLeydigCell4.6
TestisSeminiferousTubule3.9
Thalamus4.85
Thymus3.6
Thyroid5.75
Tongue4.8
Tonsil4.5
Trachea3.85
TrigeminalGanglion6.1
Uterus3.75
UterusCorpus4.15
WholeBlood5
Wholebrain3.85
colon4.65
pineal_day5.76
pineal_night5.64
retina5.575
small_intestine4.45
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_32_P114284
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala6.35 ± 0.32
Basal Forebrain6.74 ± 0.26
Basal Part of Pons6.06 ± 0.21
Cerebellar Cortex6.66 ± 0.18
Cerebellar Nuclei6.48 ± 0.38
Claustrum6.37 ± 0.3
Epithalamus6.99 ± 0.3
Frontal Lobe6.55 ± 0.37
Globus Pallidus7.26 ± 0.27
Hypothalamus6.75 ± 0.32
Insula6.38 ± 0.25
Limbic Lobe6.39 ± 0.43
Mesencephalon6.75 ± 0.36
Myelencephalon6.6 ± 0.45
Occipital Lobe6.53 ± 0.28
Parietal Lobe6.44 ± 0.42
Pontine Tegmentum6.69 ± 0.27
Striatum7.03 ± 0.4
Subthalamus6.58 ± 0.1
Temporal Lobe6.39 ± 0.31
Thalamus6.74 ± 0.26
White Matter7.9 ± 0.16
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Ikzf2CBCerebellum5.34
5.55
Ikzf2CTXCerebral cortex2.67
2.25
Ikzf2HIPHippocampal region4.87
4.87
Ikzf2HPFHippocampal formation4.63
4.1
Ikzf2HYHypothalamus0.75
0.58
Ikzf2LSXLateral septal complex0.22
0.15
Ikzf2MBMidbrain1.06
0.96
Ikzf2MYMedulla1.8
1.92
Ikzf2OLFOlfactory bulb4.89
3.53
Ikzf2PPons1.02
1.16
Ikzf2PALPallidum1.72
1.38
Ikzf2RHPRetrohippocampal region4.02
2.87
Ikzf2sAMYStriatum-like amygdalar nuclei4.82
3.07
Ikzf2STRStriatum0.88
0.61
Ikzf2STRdStriatum dorsal region0.42
0.34
Ikzf2STRvStriatum ventral region0.55
0.36
Ikzf2THThalamus2.17
2.36
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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