AutismKB 2.0

Annotation Detail for LMTK2


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Basic Information Top
Gene Symbol:LMTK2 ( AATYK2,BREK,FLJ46659,KIAA1079,KPI-2,KPI2,LMR2,cprk )
Gene Full Name: lemur tyrosine kinase 2
Band: 7q21.3
Quick LinksEntrez ID:22853; OMIM: 610989; Uniprot ID:LMTK2_HUMAN; ENSEMBL ID: ENSG00000164715; HGNC ID: 17880
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body2 / 7076128
blastocyst3 / 6231948
fetus20 / 56401235
neonate0 / 310970 
infant2 / 2362084
juvenile0 / 555560 
adult51 / 193912126
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma2 / 17475114
breast (mammary gland) tumor1 / 9417810
cervical tumor0 / 343660 
chondrosarcoma3 / 8282336
colorectal tumor3 / 11424626
esophageal tumor0 / 172900 
gastrointestinal tumor4 / 11936933
germ cell tumor4 / 26384515
glioma3 / 10688328
head and neck tumor5 / 13630236
kidney tumor2 / 6895929
leukemia1 / 9584210
liver tumor0 / 963590 
lung tumor2 / 10312719
lymphoma1 / 7175513
non-neoplasia2 / 9725020
normal104 / 336030730
ovarian tumor1 / 7668213
pancreatic tumor4 / 10461638
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer2 / 10268019
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland1 / 3319730
ascites1 / 4001524
bladder3 / 29757100
blood1 / 1234788
bone3 / 7165541
bone marrow0 / 488010 
brain22 / 110098919
cervix0 / 481710 
connective tissue2 / 14925513
ear0 / 162120 
embryonic tissue5 / 21572223
esophagus0 / 202090 
eye5 / 21105423
heart0 / 896260 
intestine10 / 23447242
kidney7 / 21177733
larynx0 / 241450 
liver2 / 2077439
lung18 / 33697453
lymph0 / 442700 
lymph node11 / 91610120
mammary gland5 / 15327132
mouth3 / 6705244
muscle2 / 10771518
nerve0 / 157680 
ovary3 / 10205129
pancreas15 / 21481269
parathyroid4 / 20539194
pharynx1 / 4132824
pituitary gland1 / 1658560
placenta3 / 28082510
prostate3 / 18934515
salivary gland0 / 201550 
skin5 / 21057423
spleen0 / 539520 
stomach2 / 9661920
testis5 / 33044215
thymus2 / 8113124
thyroid1 / 4747321
tonsil0 / 169990 
trachea1 / 5241319
umbilical cord0 / 136800 
uterus0 / 2328780 
vascular1 / 5178019
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 206223_at
Cell line Expression level Expression bar
721_B_lymphoblasts4.95
Adipocyte4
AdrenalCortex4.3
Adrenalgland3.4
Amygdala4.25
Appendix4.1
AtrioventricularNode3.05
BDCA4+_DentriticCells4.4
Bonemarrow4
BronchialEpithelialCells3.95
CD105+_Endothelial4.05
CD14+_Monocytes4.3
CD19+_BCells(neg._sel.)4.3
CD33+_Myeloid5.15
CD34+5.15
CD4+_Tcells4.35
CD56+_NKCells4.8
CD71+_EarlyErythroid3.8
CD8+_Tcells3.9
CardiacMyocytes5.2
Caudatenucleus3.6
Cerebellum3.25
CerebellumPeduncles4.55
CiliaryGanglion2.8
CingulateCortex4.1
Colorectaladenocarcinoma4.05
DorsalRootGanglion3.1
FetalThyroid3.9
Fetalbrain3.95
Fetalliver3.5
Fetallung3.3
GlobusPallidus2.95
Heart5.25
Hypothalamus4.35
Kidney3.25
Leukemia_chronicMyelogenousK-5623.6
Leukemia_promyelocytic-HL-603.5
Leukemialymphoblastic(MOLT-4)3.25
Liver5.3
Lung4.4
Lymphnode3.45
Lymphoma_burkitts(Daudi)5.1
Lymphoma_burkitts(Raji)5.65
MedullaOblongata3.7
OccipitalLobe3.6
OlfactoryBulb3.2
Ovary2.65
Pancreas3.2
PancreaticIslet4.25
ParietalLobe4.25
Pituitary4.65
Placenta4.15
Pons3.8
PrefrontalCortex5
Prostate4.65
Salivarygland3.2
SkeletalMuscle4.75
Skin3.1
SmoothMuscle4.55
Spinalcord4.3
SubthalamicNucleus3.65
SuperiorCervicalGanglion4.6
TemporalLobe3.65
Testis3.45
TestisGermCell3.35
TestisIntersitial3.4
TestisLeydigCell4
TestisSeminiferousTubule3.45
Thalamus4.1
Thymus3.15
Thyroid5
Tongue3.95
Tonsil3.9
Trachea3.4
TrigeminalGanglion4.1
Uterus3.25
UterusCorpus3.6
WholeBlood4.4
Wholebrain3.45
colon4.05
pineal_day5.02
pineal_night4.94
retina4.85
small_intestine3.85
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_17015_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala8.29 ± 0.88
Basal Forebrain7.97 ± 0.55
Basal Part of Pons7.62 ± 1.07
Cerebellar Cortex7.3 ± 0.29
Cerebellar Nuclei7.24 ± 0.66
Claustrum8.86 ± 0.96
Epithalamus7.19 ± 0.78
Frontal Lobe7.6 ± 0.56
Globus Pallidus8.49 ± 1.06
Hypothalamus7.29 ± 0.55
Insula7.69 ± 0.56
Limbic Lobe8.01 ± 0.88
Mesencephalon8 ± 0.71
Myelencephalon7.85 ± 0.93
Occipital Lobe7.96 ± 0.62
Parietal Lobe7.98 ± 0.76
Pontine Tegmentum7.71 ± 0.88
Striatum7.84 ± 1.17
Subthalamus8 ± 0.84
Temporal Lobe7.86 ± 0.75
Thalamus7.5 ± 0.61
White Matter7.17 ± 0.44
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Lmtk2CBCerebellum17.38
23.4
Lmtk2CTXCerebral cortex96.04
90.46
Lmtk2HIPHippocampal region21.59
27.24
Lmtk2HPFHippocampal formation27.77
29.48
Lmtk2HYHypothalamus2.72
2.36
Lmtk2LSXLateral septal complex11.61
7.94
Lmtk2MBMidbrain5.58
5.84
Lmtk2MYMedulla11.35
13.87
Lmtk2OLFOlfactory bulb39.16
42.72
Lmtk2PPons6.78
9.73
Lmtk2PALPallidum5.68
5.26
Lmtk2RHPRetrohippocampal region37.81
32.7
Lmtk2sAMYStriatum-like amygdalar nuclei10.19
7.39
Lmtk2STRStriatum33.66
26.14
Lmtk2STRdStriatum dorsal region43.59
34.18
Lmtk2STRvStriatum ventral region24.04
18.87
Lmtk2THThalamus11.26
10.36
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00004965 11 259 269 LHFLHSDLALR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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