AutismKB 2.0

Annotation Detail for LPHN1


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Basic Information Top
Gene Symbol:LPHN1 ( CIRL1,CL1,LEC2 )
Gene Full Name: latrophilin 1
Band: 19p13.2
Quick LinksEntrez ID:22859; OMIM: NA; Uniprot ID:LPHN1_HUMAN; ENSEMBL ID: ENSG00000072071; HGNC ID:
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body8 / 70761113
blastocyst12 / 62319192
fetus21 / 56401237
neonate0 / 310970 
infant1 / 2362042
juvenile1 / 5555617
adult118 / 193912160
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor2 / 12794156
bladder carcinoma2 / 17475114
breast (mammary gland) tumor4 / 9417842
cervical tumor1 / 3436629
chondrosarcoma5 / 8282360
colorectal tumor11 / 11424696
esophageal tumor0 / 172900 
gastrointestinal tumor14 / 119369117
germ cell tumor15 / 26384556
glioma14 / 106883130
head and neck tumor7 / 13630251
kidney tumor4 / 6895958
leukemia0 / 958420 
liver tumor2 / 9635920
lung tumor7 / 10312767
lymphoma0 / 717550 
non-neoplasia4 / 9725041
normal132 / 336030739
ovarian tumor7 / 7668291
pancreatic tumor2 / 10461619
primitive neuroectodermal tumor of the CNS12 / 12568095
prostate cancer5 / 10268048
retinoblastoma12 / 46356258
skin tumor4 / 12494932
soft tissue/muscle tissue tumor8 / 12519163
uterine tumor2 / 9025722
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland2 / 3319760
ascites4 / 4001599
bladder1 / 2975733
blood0 / 1234780 
bone6 / 7165583
bone marrow0 / 488010 
brain86 / 110098978
cervix1 / 4817120
connective tissue3 / 14925520
ear0 / 162120 
embryonic tissue21 / 21572297
esophagus1 / 2020949
eye29 / 211054137
heart3 / 8962633
intestine17 / 23447272
kidney5 / 21177723
larynx2 / 2414582
liver2 / 2077439
lung18 / 33697453
lymph0 / 442700 
lymph node1 / 9161010
mammary gland7 / 15327145
mouth0 / 670520 
muscle4 / 10771537
nerve1 / 1576863
ovary14 / 102051137
pancreas5 / 21481223
parathyroid1 / 2053948
pharynx0 / 413280 
pituitary gland2 / 16585120
placenta1 / 2808253
prostate10 / 18934552
salivary gland0 / 201550 
skin4 / 21057418
spleen1 / 5395218
stomach4 / 9661941
testis3 / 3304429
thymus0 / 811310 
thyroid5 / 47473105
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus5 / 23287821
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 203488_at
Cell line Expression level Expression bar
721_B_lymphoblasts16.7
Adipocyte31.65
AdrenalCortex28.5
Adrenalgland23
Amygdala84.65
Appendix27.5
AtrioventricularNode20.75
BDCA4+_DentriticCells42
Bonemarrow26.85
BronchialEpithelialCells20.45
CD105+_Endothelial27.8
CD14+_Monocytes25.3
CD19+_BCells(neg._sel.)20.2
CD33+_Myeloid35.45
CD34+35.1
CD4+_Tcells29.55
CD56+_NKCells40.2
CD71+_EarlyErythroid25.8
CD8+_Tcells22.6
CardiacMyocytes34.05
Caudatenucleus41.05
Cerebellum24.7
CerebellumPeduncles73.25
CiliaryGanglion22.15
CingulateCortex78
Colorectaladenocarcinoma29.4
DorsalRootGanglion34.1
FetalThyroid28.65
Fetalbrain103.2
Fetalliver23.5
Fetallung23.55
GlobusPallidus68.75
Heart29.9
Hypothalamus41.15
Kidney21.9
Leukemia_chronicMyelogenousK-56224.8
Leukemia_promyelocytic-HL-6024.15
Leukemialymphoblastic(MOLT-4)22.1
Liver35.7
Lung28.6
Lymphnode22.35
Lymphoma_burkitts(Daudi)34.2
Lymphoma_burkitts(Raji)35.55
MedullaOblongata49.4
OccipitalLobe60.9
OlfactoryBulb21.7
Ovary18.95
Pancreas21.9
PancreaticIslet29.3
ParietalLobe89.2
Pituitary32.1
Placenta24.45
Pons52.75
PrefrontalCortex216.65
Prostate32.35
Salivarygland21.75
SkeletalMuscle32.75
Skin21.05
SmoothMuscle31.2
Spinalcord37
SubthalamicNucleus80.65
SuperiorCervicalGanglion40.45
TemporalLobe46.75
Testis23.5
TestisGermCell23.05
TestisIntersitial21.5
TestisLeydigCell24.1
TestisSeminiferousTubule24.65
Thalamus56.6
Thymus21.7
Thyroid34.95
Tongue26.65
Tonsil25.95
Trachea22.65
TrigeminalGanglion32.25
Uterus22.7
UterusCorpus24.35
WholeBlood22.25
Wholebrain92.95
colon9.1
pineal_day121.24
pineal_night110.34
retina45.325
small_intestine8.65
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P208551
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala12.26 ± 0.44
Basal Forebrain11.74 ± 0.11
Basal Part of Pons12.03 ± 0.18
Cerebellar Cortex12.19 ± 0.28
Cerebellar Nuclei11.41 ± 0.5
Claustrum12.17 ± 0.27
Epithalamus11.32 ± 0.35
Frontal Lobe12.08 ± 0.39
Globus Pallidus10.67 ± 0.28
Hypothalamus11.53 ± 0.4
Insula12.18 ± 0.22
Limbic Lobe12.38 ± 0.41
Mesencephalon11.83 ± 0.36
Myelencephalon11.98 ± 0.32
Occipital Lobe12.17 ± 0.41
Parietal Lobe12.04 ± 0.36
Pontine Tegmentum11.86 ± 0.32
Striatum11.82 ± 0.43
Subthalamus11.68 ± 0.18
Temporal Lobe12.22 ± 0.32
Thalamus11.96 ± 0.32
White Matter10.94 ± 0.54
Mouse Brain ISH
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00076820 18 466 483 RPPAPNLHVSPELFCEPR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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