AutismKB 2.0

Annotation Detail for NLGN1


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Basic Information Top
Gene Symbol:NLGN1 ( KIAA1070,MGC45115,NL1 )
Gene Full Name: neuroligin 1
Band: 3q26.31
Quick LinksEntrez ID:22871; OMIM: 600568; Uniprot ID:NLGN1_HUMAN; ENSEMBL ID: ENSG00000169760; HGNC ID: 14291
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body1 / 7076114
blastocyst0 / 623190 
fetus19 / 56401233
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult20 / 193912110
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor1 / 1193698
germ cell tumor5 / 26384518
glioma0 / 1068830 
head and neck tumor2 / 13630214
kidney tumor2 / 6895929
leukemia0 / 958420 
liver tumor0 / 963590 
lung tumor2 / 10312719
lymphoma0 / 717550 
non-neoplasia2 / 9725020
normal51 / 336030715
ovarian tumor0 / 766820 
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer1 / 1026809
retinoblastoma0 / 463560 
skin tumor1 / 1249498
soft tissue/muscle tissue tumor4 / 12519131
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland1 / 3319730
ascites0 / 400150 
bladder0 / 297570 
blood0 / 1234780 
bone0 / 716550 
bone marrow0 / 488010 
brain30 / 110098927
cervix0 / 481710 
connective tissue2 / 14925513
ear2 / 16212123
embryonic tissue3 / 21572213
esophagus0 / 202090 
eye4 / 21105418
heart0 / 896260 
intestine1 / 2344724
kidney4 / 21177718
larynx0 / 241450 
liver0 / 2077430 
lung9 / 33697426
lymph0 / 442700 
lymph node0 / 916100 
mammary gland0 / 1532710 
mouth2 / 6705229
muscle1 / 1077159
nerve0 / 157680 
ovary0 / 1020510 
pancreas0 / 2148120 
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland1 / 1658560
placenta1 / 2808253
prostate1 / 1893455
salivary gland0 / 201550 
skin3 / 21057414
spleen0 / 539520 
stomach0 / 966190 
testis19 / 33044257
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus0 / 2328780 
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 205893_at
Cell line Expression level Expression bar
721_B_lymphoblasts7.55
Adipocyte6.95
AdrenalCortex9.55
Adrenalgland6.45
Amygdala31.7
Appendix10.75
AtrioventricularNode10.1
BDCA4+_DentriticCells7.05
Bonemarrow7.75
BronchialEpithelialCells6.7
CD105+_Endothelial7.25
CD14+_Monocytes7.65
CD19+_BCells(neg._sel.)7.5
CD33+_Myeloid8.45
CD34+8.35
CD4+_Tcells7
CD56+_NKCells8.25
CD71+_EarlyErythroid6.9
CD8+_Tcells6.15
CardiacMyocytes15.55
Caudatenucleus6.55
Cerebellum6
CerebellumPeduncles9.4
CiliaryGanglion7.45
CingulateCortex8.3
Colorectaladenocarcinoma7.15
DorsalRootGanglion8.2
FetalThyroid7.15
Fetalbrain24.7
Fetalliver6.35
Fetallung5.5
GlobusPallidus6.8
Heart11.9
Hypothalamus9.6
Kidney6.5
Leukemia_chronicMyelogenousK-5626.4
Leukemia_promyelocytic-HL-606.35
Leukemialymphoblastic(MOLT-4)5.3
Liver10.95
Lung7.8
Lymphnode5.8
Lymphoma_burkitts(Daudi)9.5
Lymphoma_burkitts(Raji)11.25
MedullaOblongata12.9
OccipitalLobe24.85
OlfactoryBulb5.55
Ovary7.7
Pancreas6
PancreaticIslet7.95
ParietalLobe8.3
Pituitary8.75
Placenta6.85
Pons7.35
PrefrontalCortex20.9
Prostate8.35
Salivarygland6.05
SkeletalMuscle13
Skin7.75
SmoothMuscle8.1
Spinalcord7.7
SubthalamicNucleus7.4
SuperiorCervicalGanglion16.4
TemporalLobe6.8
Testis6.25
TestisGermCell5.75
TestisIntersitial6.4
TestisLeydigCell7.95
TestisSeminiferousTubule6.2
Thalamus7.6
Thymus5.15
Thyroid8.35
Tongue9.2
Tonsil7.15
Trachea6
TrigeminalGanglion10.15
Uterus5.8
UterusCorpus7.9
WholeBlood7.75
Wholebrain7.5
colon7.1
pineal_day8.66
pineal_night8.62
retina8.525
small_intestine6.65
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_10016_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala7 ± 0.4
Basal Forebrain6.65 ± 0.41
Basal Part of Pons6.36 ± 0.3
Cerebellar Cortex6.86 ± 0.46
Cerebellar Nuclei6.6 ± 0.44
Claustrum5.96 ± 0.46
Epithalamus5.86 ± 0.74
Frontal Lobe6.5 ± 0.47
Globus Pallidus6.09 ± 0.31
Hypothalamus6.64 ± 0.62
Insula6.9 ± 0.7
Limbic Lobe7.01 ± 0.42
Mesencephalon6.6 ± 0.44
Myelencephalon6.62 ± 0.52
Occipital Lobe6.87 ± 0.3
Parietal Lobe6.63 ± 0.5
Pontine Tegmentum6.76 ± 0.51
Striatum6.63 ± 0.39
Subthalamus6.47 ± 0.12
Temporal Lobe6.79 ± 0.43
Thalamus6.52 ± 0.42
White Matter6.01 ± 0.13
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Nlgn1CBCerebellum8.81
8.33
Nlgn1CTXCerebral cortex82.22
55.54
Nlgn1HIPHippocampal region36.78
48.49
Nlgn1HPFHippocampal formation45.98
45.81
Nlgn1HYHypothalamus25.77
12.52
Nlgn1LSXLateral septal complex52.92
33.35
Nlgn1MBMidbrain18.63
11.6
Nlgn1MYMedulla19.84
15.45
Nlgn1OLFOlfactory bulb63.54
42.84
Nlgn1PPons15.44
11.12
Nlgn1PALPallidum30.7
18.05
Nlgn1RHPRetrohippocampal region60.53
43.75
Nlgn1sAMYStriatum-like amygdalar nuclei40.47
21.41
Nlgn1STRStriatum52.89
29.02
Nlgn1STRdStriatum dorsal region52.58
28.76
Nlgn1STRvStriatum ventral region64.83
34.75
Nlgn1THThalamus17.91
11.85
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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