AutismKB 2.0

Annotation Detail for ENPP4


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:ENPP4 ( KIAA0879,NPP4 )
Gene Full Name: ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative)
Band: 6p21.1
Quick LinksEntrez ID:22875; OMIM: NA; Uniprot ID:ENPP4_HUMAN; ENSEMBL ID: ENSG00000001561; HGNC ID: 3359
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body1 / 7076114
blastocyst0 / 623190 
fetus7 / 56401212
neonate0 / 310970 
infant0 / 236200 
juvenile1 / 5555617
adult50 / 193912125
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor2 / 12794156
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor7 / 11424661
esophageal tumor0 / 172900 
gastrointestinal tumor3 / 11936925
germ cell tumor3 / 26384511
glioma0 / 1068830 
head and neck tumor2 / 13630214
kidney tumor1 / 6895914
leukemia9 / 9584293
liver tumor0 / 963590 
lung tumor1 / 1031279
lymphoma0 / 717550 
non-neoplasia4 / 9725041
normal110 / 336030732
ovarian tumor0 / 766820 
pancreatic tumor7 / 10461666
primitive neuroectodermal tumor of the CNS1 / 1256807
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor1 / 1249498
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor9 / 9025799
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland2 / 3319760
ascites2 / 4001549
bladder0 / 297570 
blood9 / 12347872
bone1 / 7165513
bone marrow1 / 4880120
brain92 / 110098983
cervix0 / 481710 
connective tissue1 / 1492556
ear0 / 162120 
embryonic tissue1 / 2157224
esophagus0 / 202090 
eye3 / 21105414
heart0 / 896260 
intestine10 / 23447242
kidney5 / 21177723
larynx0 / 241450 
liver3 / 20774314
lung4 / 33697411
lymph0 / 442700 
lymph node8 / 9161087
mammary gland2 / 15327113
mouth0 / 670520 
muscle4 / 10771537
nerve0 / 157680 
ovary0 / 1020510 
pancreas12 / 21481255
parathyroid2 / 2053997
pharynx2 / 4132848
pituitary gland1 / 1658560
placenta2 / 2808257
prostate3 / 18934515
salivary gland0 / 201550 
skin1 / 2105744
spleen1 / 5395218
stomach1 / 9661910
testis6 / 33044218
thymus2 / 8113124
thyroid1 / 4747321
tonsil0 / 169990 
trachea4 / 5241376
umbilical cord0 / 136800 
uterus11 / 23287847
vascular1 / 5178019
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 204160_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts29.3
Adipocyte11.25
AdrenalCortex15.5
Adrenalgland9.6
Amygdala162.95
Appendix16.2
AtrioventricularNode10.85
BDCA4+_DentriticCells40.2
Bonemarrow12.15
BronchialEpithelialCells8.95
CD105+_Endothelial22.3
CD14+_Monocytes12.05
CD19+_BCells(neg._sel.)22.95
CD33+_Myeloid18.15
CD34+29
CD4+_Tcells35.7
CD56+_NKCells378.35
CD71+_EarlyErythroid12.2
CD8+_Tcells94.95
CardiacMyocytes15.9
Caudatenucleus50.15
Cerebellum9.75
CerebellumPeduncles15.45
CiliaryGanglion21.8
CingulateCortex34.4
Colorectaladenocarcinoma13.05
DorsalRootGanglion15.1
FetalThyroid13.8
Fetalbrain15.9
Fetalliver11.55
Fetallung11.35
GlobusPallidus20.85
Heart16.1
Hypothalamus147.95
Kidney10.15
Leukemia_chronicMyelogenousK-5628.85
Leukemia_promyelocytic-HL-6011.1
Leukemialymphoblastic(MOLT-4)9.8
Liver16.55
Lung12.4
Lymphnode11.3
Lymphoma_burkitts(Daudi)17.4
Lymphoma_burkitts(Raji)18.1
MedullaOblongata33.5
OccipitalLobe78.55
OlfactoryBulb11.55
Ovary9.3
Pancreas12.85
PancreaticIslet63.85
ParietalLobe69.3
Pituitary49.45
Placenta7.75
Pons21
PrefrontalCortex55.4
Prostate15.35
Salivarygland14.65
SkeletalMuscle18.5
Skin11.15
SmoothMuscle12
Spinalcord123.65
SubthalamicNucleus27.7
SuperiorCervicalGanglion22.65
TemporalLobe13.8
Testis9.3
TestisGermCell34.6
TestisIntersitial12.9
TestisLeydigCell16.6
TestisSeminiferousTubule11.75
Thalamus58.05
Thymus7.5
Thyroid36.7
Tongue16
Tonsil10.8
Trachea22.6
TrigeminalGanglion25
Uterus10.85
UterusCorpus13.15
WholeBlood20.1
Wholebrain35.85
colon20.85
pineal_day64.42
pineal_night126.9
retina67.25
small_intestine12.5
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_6540_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala6.08 ± 0.39
Basal Forebrain6.42 ± 0.36
Basal Part of Pons6.5 ± 0.33
Cerebellar Cortex6.28 ± 0.25
Cerebellar Nuclei7.01 ± 0.45
Claustrum6.36 ± 0.55
Epithalamus6.7 ± 0.27
Frontal Lobe6.6 ± 0.35
Globus Pallidus7.25 ± 0.33
Hypothalamus6.34 ± 0.4
Insula6.31 ± 0.2
Limbic Lobe6.35 ± 0.33
Mesencephalon6.54 ± 0.45
Myelencephalon6.51 ± 0.44
Occipital Lobe6.42 ± 0.28
Parietal Lobe6.47 ± 0.46
Pontine Tegmentum6.59 ± 0.34
Striatum6.35 ± 0.46
Subthalamus6.8 ± 0.65
Temporal Lobe6.39 ± 0.36
Thalamus6.71 ± 0.39
White Matter8.42 ± 0.3
Mouse Brain ISH
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00042101 16 343 358 PSMHPFLAAHGPAFHK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved