AutismKB 2.0

Annotation Detail for FKBP5


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Basic Information Top
Gene Symbol:FKBP5 ( AIG6,FKBP51,FKBP54,MGC111006,P54,PPIase,Ptg-10 )
Gene Full Name: FK506 binding protein 5
Band: 6p21.31
Quick LinksEntrez ID:2289; OMIM: 602623; Uniprot ID:FKBP5_HUMAN; ENSEMBL ID: ENSG00000096060; HGNC ID: 3721
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body2 / 7076128
blastocyst6 / 6231996
fetus42 / 56401274
neonate0 / 310970 
infant1 / 2362042
juvenile6 / 55556107
adult183 / 193912194
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor2 / 9417821
cervical tumor0 / 343660 
chondrosarcoma10 / 82823120
colorectal tumor4 / 11424635
esophageal tumor2 / 17290115
gastrointestinal tumor7 / 11936958
germ cell tumor12 / 26384545
glioma7 / 10688365
head and neck tumor8 / 13630258
kidney tumor3 / 6895943
leukemia7 / 9584273
liver tumor7 / 9635972
lung tumor2 / 10312719
lymphoma4 / 7175555
non-neoplasia9 / 9725092
normal264 / 336030778
ovarian tumor5 / 7668265
pancreatic tumor8 / 10461676
primitive neuroectodermal tumor of the CNS9 / 12568071
prostate cancer33 / 102680321
retinoblastoma3 / 4635664
skin tumor2 / 12494916
soft tissue/muscle tissue tumor4 / 12519131
uterine tumor3 / 9025733
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites1 / 4001524
bladder0 / 297570 
blood21 / 123478170
bone13 / 71655181
bone marrow3 / 4880161
brain75 / 110098968
cervix1 / 4817120
connective tissue13 / 14925587
ear0 / 162120 
embryonic tissue13 / 21572260
esophagus2 / 2020998
eye16 / 21105475
heart6 / 8962666
intestine19 / 23447281
kidney10 / 21177747
larynx1 / 2414541
liver17 / 20774381
lung20 / 33697459
lymph0 / 442700 
lymph node10 / 91610109
mammary gland9 / 15327158
mouth4 / 6705259
muscle14 / 107715129
nerve0 / 157680 
ovary7 / 10205168
pancreas19 / 21481288
parathyroid3 / 20539146
pharynx2 / 4132848
pituitary gland1 / 1658560
placenta7 / 28082524
prostate40 / 189345211
salivary gland0 / 201550 
skin4 / 21057418
spleen8 / 53952148
stomach5 / 9661951
testis46 / 330442139
thymus60 / 81131739
thyroid3 / 4747363
tonsil0 / 169990 
trachea30 / 52413572
umbilical cord0 / 136800 
uterus42 / 232878180
vascular3 / 5178057
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 204560_at
Cell line Expression level Expression bar
721_B_lymphoblasts46.6
Adipocyte107.55
AdrenalCortex9.5
Adrenalgland6.7
Amygdala7.8
Appendix10.1
AtrioventricularNode11.45
BDCA4+_DentriticCells32.6
Bonemarrow9.2
BronchialEpithelialCells14.3
CD105+_Endothelial8.2
CD14+_Monocytes11.05
CD19+_BCells(neg._sel.)7.9
CD33+_Myeloid10.4
CD34+34.65
CD4+_Tcells58.05
CD56+_NKCells10.4
CD71+_EarlyErythroid8.25
CD8+_Tcells38
CardiacMyocytes10.9
Caudatenucleus7
Cerebellum6.2
CerebellumPeduncles9.85
CiliaryGanglion5.7
CingulateCortex8.15
Colorectaladenocarcinoma7.6
DorsalRootGanglion6.1
FetalThyroid7.6
Fetalbrain7.4
Fetalliver6.5
Fetallung7.15
GlobusPallidus5.7
Heart11.15
Hypothalamus8.2
Kidney6.5
Leukemia_chronicMyelogenousK-5627
Leukemia_promyelocytic-HL-607.15
Leukemialymphoblastic(MOLT-4)7.5
Liver10.85
Lung12.15
Lymphnode8.05
Lymphoma_burkitts(Daudi)10.35
Lymphoma_burkitts(Raji)11.35
MedullaOblongata7.2
OccipitalLobe7
OlfactoryBulb6.15
Ovary9.3
Pancreas6.5
PancreaticIslet8.6
ParietalLobe8.45
Pituitary9.4
Placenta7.7
Pons7.6
PrefrontalCortex9.55
Prostate12.3
Salivarygland8.9
SkeletalMuscle63.65
Skin6
SmoothMuscle8.25
Spinalcord8.65
SubthalamicNucleus7.3
SuperiorCervicalGanglion9.3
TemporalLobe7.6
Testis6.95
TestisGermCell13.45
TestisIntersitial6.85
TestisLeydigCell10.1
TestisSeminiferousTubule7.35
Thalamus7.85
Thymus15.55
Thyroid9.9
Tongue9.9
Tonsil7.85
Trachea7.25
TrigeminalGanglion8.05
Uterus6.6
UterusCorpus7.4
WholeBlood10.3
Wholebrain6.1
colon8.15
pineal_day9.12
pineal_night9.12
retina9.925
small_intestine7.8
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_1369_PI416573500
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala5.3 ± 0.75
Basal Forebrain4.96 ± 0.47
Basal Part of Pons3.87 ± 0.57
Cerebellar Cortex4.11 ± 0.63
Cerebellar Nuclei4.72 ± 0.42
Claustrum5.92 ± 0.94
Epithalamus4.46 ± 0.54
Frontal Lobe4.96 ± 1.01
Globus Pallidus7.13 ± 0.38
Hypothalamus4.59 ± 0.53
Insula4.57 ± 0.37
Limbic Lobe5.58 ± 1.09
Mesencephalon5.35 ± 0.42
Myelencephalon4.93 ± 0.85
Occipital Lobe5.82 ± 0.8
Parietal Lobe5.35 ± 0.8
Pontine Tegmentum5.53 ± 0.55
Striatum6.05 ± 0.65
Subthalamus4.92 ± 0.39
Temporal Lobe4.65 ± 0.7
Thalamus4.72 ± 0.64
White Matter6.22 ± 0.42
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Fkbp5CBCerebellum100
100
Fkbp5CTXCerebral cortex100
93.24
Fkbp5HIPHippocampal region83.82
100
Fkbp5HPFHippocampal formation87.57
100
Fkbp5HYHypothalamus40.01
27.8
Fkbp5LSXLateral septal complex83.22
55.73
Fkbp5MBMidbrain28.15
21.34
Fkbp5MYMedulla42.63
42.36
Fkbp5OLFOlfactory bulb100
90
Fkbp5PPons20.83
18.32
Fkbp5PALPallidum53.12
43.35
Fkbp5RHPRetrohippocampal region92.86
77.97
Fkbp5sAMYStriatum-like amygdalar nuclei79.86
62.2
Fkbp5STRStriatum100
76.84
Fkbp5STRdStriatum dorsal region100
78.93
Fkbp5STRvStriatum ventral region100
89.55
Fkbp5THThalamus38.34
30.56
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
FKBP5_HUMAN_0 0 0 0 YMQAVIQYGK PRIDE
FKBP5_HUMAN_1 31 1 31 MTTDEGAKNNEESPTATVAEQGEDITSKKDR PRIDE
FKBP5_HUMAN_154 21 154 174 KGEGYSNPNEGATVEIHLEGR PRIDE
FKBP5_HUMAN_2 30 2 31 TTDEGAKNNEESPTATVAEQGEDITSKKDR PRIDE
FKBP5_HUMAN_357 15 357 371 RGEAQLLMNEFESAK PRIDE
FKBP5_HUMAN_432 25 432 456 TSEGVTNEKGTDSQAMEEEKPEGHV PRIDE
FKBP5_HUMAN_441 16 441 456 GTDSQAMEEEKPEGHV PRIDE
PAp00009353 17 336 352 AVECCDKALGLDSANEK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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