AutismKB 2.0

Annotation Detail for DENND3


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Basic Information Top
Gene Symbol:DENND3 ( KIAA0870 )
Gene Full Name: DENN/MADD domain containing 3
Band: 8q24.3
Quick LinksEntrez ID:22898; OMIM: NA; Uniprot ID:DEND3_HUMAN; ENSEMBL ID: ENSG00000105339; HGNC ID: 29134
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body1 / 7076114
blastocyst0 / 623190 
fetus25 / 56401244
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult88 / 193912145
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma3 / 8282336
colorectal tumor3 / 11424626
esophageal tumor0 / 172900 
gastrointestinal tumor3 / 11936925
germ cell tumor9 / 26384534
glioma4 / 10688337
head and neck tumor4 / 13630229
kidney tumor2 / 6895929
leukemia11 / 95842114
liver tumor0 / 963590 
lung tumor3 / 10312729
lymphoma0 / 717550 
non-neoplasia4 / 9725041
normal166 / 336030749
ovarian tumor2 / 7668226
pancreatic tumor1 / 1046169
primitive neuroectodermal tumor of the CNS3 / 12568023
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor1 / 1249498
soft tissue/muscle tissue tumor1 / 1251917
uterine tumor2 / 9025722
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites2 / 4001549
bladder0 / 297570 
blood9 / 12347872
bone2 / 7165527
bone marrow7 / 48801143
brain28 / 110098925
cervix3 / 4817162
connective tissue3 / 14925520
ear0 / 162120 
embryonic tissue1 / 2157224
esophagus1 / 2020949
eye3 / 21105414
heart2 / 8962622
intestine8 / 23447234
kidney6 / 21177728
larynx0 / 241450 
liver2 / 2077439
lung17 / 33697450
lymph0 / 442700 
lymph node71 / 91610775
mammary gland5 / 15327132
mouth4 / 6705259
muscle3 / 10771527
nerve0 / 157680 
ovary2 / 10205119
pancreas7 / 21481232
parathyroid1 / 2053948
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta4 / 28082514
prostate9 / 18934547
salivary gland0 / 201550 
skin1 / 2105744
spleen4 / 5395274
stomach1 / 9661910
testis1 / 3304423
thymus4 / 8113149
thyroid0 / 474730 
tonsil0 / 169990 
trachea4 / 5241376
umbilical cord2 / 13680146
uterus8 / 23287834
vascular1 / 5178019
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 212975_at
Cell line Expression level Expression bar
721_B_lymphoblasts39.05
Adipocyte23.05
AdrenalCortex23.9
Adrenalgland21.65
Amygdala25
Appendix23.35
AtrioventricularNode18.6
BDCA4+_DentriticCells27.75
Bonemarrow40.35
BronchialEpithelialCells20.5
CD105+_Endothelial23.35
CD14+_Monocytes133.6
CD19+_BCells(neg._sel.)60.4
CD33+_Myeloid283
CD34+46.2
CD4+_Tcells25
CD56+_NKCells168.45
CD71+_EarlyErythroid21.85
CD8+_Tcells21.35
CardiacMyocytes28.95
Caudatenucleus21.2
Cerebellum19.3
CerebellumPeduncles26.15
CiliaryGanglion18.35
CingulateCortex26.65
Colorectaladenocarcinoma23
DorsalRootGanglion17.6
FetalThyroid26.05
Fetalbrain23.8
Fetalliver20.3
Fetallung23.95
GlobusPallidus20.7
Heart29.4
Hypothalamus27.7
Kidney19.8
Leukemia_chronicMyelogenousK-56220.8
Leukemia_promyelocytic-HL-6020.6
Leukemialymphoblastic(MOLT-4)18.65
Liver30.2
Lung83
Lymphnode30.75
Lymphoma_burkitts(Daudi)29.9
Lymphoma_burkitts(Raji)104.35
MedullaOblongata21.3
OccipitalLobe22.7
OlfactoryBulb21.25
Ovary16.6
Pancreas18.8
PancreaticIslet24.65
ParietalLobe29.55
Pituitary27.55
Placenta24
Pons22.3
PrefrontalCortex33.15
Prostate29.15
Salivarygland28
SkeletalMuscle26.15
Skin25.1
SmoothMuscle25.9
Spinalcord25.4
SubthalamicNucleus24.4
SuperiorCervicalGanglion26.6
TemporalLobe21.5
Testis20.25
TestisGermCell19.1
TestisIntersitial19.55
TestisLeydigCell31.25
TestisSeminiferousTubule20.1
Thalamus24.1
Thymus17.7
Thyroid28.25
Tongue22.6
Tonsil23.8
Trachea19.5
TrigeminalGanglion29.4
Uterus19.2
UterusCorpus20.65
WholeBlood115.95
Wholebrain20.55
colon23.55
pineal_day29.04
pineal_night28.04
retina28.6
small_intestine22.25
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_6014_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala4.19 ± 0.78
Basal Forebrain3.53 ± 0.54
Basal Part of Pons3.9 ± 0.47
Cerebellar Cortex3.66 ± 0.62
Cerebellar Nuclei3.69 ± 0.4
Claustrum4.35 ± 0.67
Epithalamus3.7 ± 0.76
Frontal Lobe3.8 ± 0.55
Globus Pallidus3.74 ± 0.47
Hypothalamus3.64 ± 0.39
Insula3.77 ± 0.47
Limbic Lobe3.93 ± 0.51
Mesencephalon3.98 ± 0.55
Myelencephalon3.83 ± 0.56
Occipital Lobe4.01 ± 0.48
Parietal Lobe3.97 ± 0.57
Pontine Tegmentum3.73 ± 0.64
Striatum3.47 ± 0.62
Subthalamus4.13 ± 0.26
Temporal Lobe3.89 ± 0.52
Thalamus3.68 ± 0.59
White Matter3.68 ± 0.44
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Dennd3CBCerebellum3.42
3.69
Dennd3CTXCerebral cortex5.57
4.56
Dennd3HIPHippocampal region5.88
5.85
Dennd3HPFHippocampal formation6.87
6.2
Dennd3HYHypothalamus1.25
0.89
Dennd3LSXLateral septal complex0.57
0.57
Dennd3MBMidbrain5.61
5.02
Dennd3MYMedulla7.92
9.16
Dennd3OLFOlfactory bulb7.73
7.12
Dennd3PPons7.28
7.44
Dennd3PALPallidum0.46
0.4
Dennd3RHPRetrohippocampal region8.53
6.69
Dennd3sAMYStriatum-like amygdalar nuclei1.47
0.94
Dennd3STRStriatum0.8
0.63
Dennd3STRdStriatum dorsal region0.64
0.55
Dennd3STRvStriatum ventral region1.03
0.7
Dennd3THThalamus0.69
0.65
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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