AutismKB 2.0

Annotation Detail for KLRK1


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Basic Information Top
Gene Symbol:KLRK1 ( CD314,D12S2489E,FLJ17759,FLJ75772,KLR,NKG2-D,NKG2D )
Gene Full Name: killer cell lectin-like receptor subfamily K, member 1
Band: 12p13.2
Quick LinksEntrez ID:22914; OMIM: 611817; Uniprot ID:NKG2D_HUMAN; ENSEMBL ID: ENSG00000213809; HGNC ID: 18788
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus1 / 5640121
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult17 / 19391218
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor7 / 34366203
chondrosarcoma1 / 8282312
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor4 / 26384515
glioma0 / 1068830 
head and neck tumor0 / 1363020 
kidney tumor0 / 689590 
leukemia1 / 9584210
liver tumor1 / 9635910
lung tumor0 / 1031270 
lymphoma6 / 7175583
non-neoplasia0 / 972500 
normal30 / 33603078
ovarian tumor3 / 7668239
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor2 / 12494916
soft tissue/muscle tissue tumor1 / 1251917
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood4 / 12347832
bone0 / 716550 
bone marrow0 / 488010 
brain1 / 11009890 
cervix7 / 48171145
connective tissue1 / 1492556
ear0 / 162120 
embryonic tissue0 / 2157220 
esophagus0 / 202090 
eye0 / 2110540 
heart0 / 896260 
intestine0 / 2344720 
kidney1 / 2117774
larynx0 / 241450 
liver1 / 2077434
lung1 / 3369742
lymph3 / 4427067
lymph node4 / 9161043
mammary gland0 / 1532710 
mouth0 / 670520 
muscle0 / 1077150 
nerve0 / 157680 
ovary3 / 10205129
pancreas0 / 2148120 
parathyroid0 / 205390 
pharynx2 / 4132848
pituitary gland0 / 165850 
placenta7 / 28082524
prostate0 / 1893450 
salivary gland0 / 201550 
skin2 / 2105749
spleen10 / 53952185
stomach1 / 9661910
testis0 / 3304420 
thymus1 / 8113112
thyroid0 / 474730 
tonsil0 / 169990 
trachea1 / 5241319
umbilical cord0 / 136800 
uterus4 / 23287817
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 205821_at
Cell line Expression level Expression bar
721_B_lymphoblasts7.5
Adipocyte12.4
AdrenalCortex12.75
Adrenalgland10.35
Amygdala13.05
Appendix16.95
AtrioventricularNode22.7
BDCA4+_DentriticCells25.9
Bonemarrow20.1
BronchialEpithelialCells12.1
CD105+_Endothelial12.5
CD14+_Monocytes11.05
CD19+_BCells(neg._sel.)20.7
CD33+_Myeloid15.9
CD34+12.25
CD4+_Tcells1637.9
CD56+_NKCells1311.4
CD71+_EarlyErythroid11.85
CD8+_Tcells3532.95
CardiacMyocytes15.7
Caudatenucleus11.15
Cerebellum10.05
CerebellumPeduncles13.95
CiliaryGanglion11.7
CingulateCortex14.5
Colorectaladenocarcinoma12.3
DorsalRootGanglion14.4
FetalThyroid12.05
Fetalbrain12.55
Fetalliver10.55
Fetallung10.45
GlobusPallidus15.85
Heart15.55
Hypothalamus13.35
Kidney14.85
Leukemia_chronicMyelogenousK-56212.15
Leukemia_promyelocytic-HL-6029.65
Leukemialymphoblastic(MOLT-4)10.05
Liver16.15
Lung12
Lymphnode142
Lymphoma_burkitts(Daudi)15.75
Lymphoma_burkitts(Raji)17.05
MedullaOblongata13.8
OccipitalLobe11.1
OlfactoryBulb17.75
Ovary9.65
Pancreas9.4
PancreaticIslet13.25
ParietalLobe15.2
Pituitary15.9
Placenta12.65
Pons13.7
PrefrontalCortex15.4
Prostate14.3
Salivarygland28.5
SkeletalMuscle38.5
Skin23.5
SmoothMuscle13.95
Spinalcord13.3
SubthalamicNucleus19.65
SuperiorCervicalGanglion22.45
TemporalLobe11.65
Testis10.8
TestisGermCell10.35
TestisIntersitial16.1
TestisLeydigCell12.2
TestisSeminiferousTubule11.5
Thalamus12.65
Thymus10.6
Thyroid15.35
Tongue12.35
Tonsil39.7
Trachea11.85
TrigeminalGanglion14.65
Uterus10.3
UterusCorpus14.05
WholeBlood311.85
Wholebrain10.45
colon12.5
pineal_day16.74
pineal_night14.44
retina16.9
small_intestine12.05
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_16750_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala2.37 ± 0.93
Basal Forebrain2.58 ± 1.09
Basal Part of Pons1.61 ± 0.35
Cerebellar Cortex1.74 ± 0.63
Cerebellar Nuclei2.23 ± 0.73
Claustrum2.85 ± 0.87
Epithalamus1.77 ± 0.75
Frontal Lobe1.77 ± 0.65
Globus Pallidus2.59 ± 0.49
Hypothalamus1.93 ± 0.57
Insula1.8 ± 0.61
Limbic Lobe1.96 ± 0.64
Mesencephalon2.1 ± 0.68
Myelencephalon1.98 ± 0.68
Occipital Lobe2.09 ± 0.78
Parietal Lobe1.93 ± 0.74
Pontine Tegmentum1.98 ± 0.69
Striatum2.13 ± 0.61
Subthalamus2.16 ± 0.75
Temporal Lobe1.81 ± 0.6
Thalamus1.89 ± 0.56
White Matter2.33 ± 0.17
Mouse Brain ISH
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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