AutismKB 2.0

Annotation Detail for SEPHS1


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Basic Information Top
Gene Symbol:SEPHS1 ( MGC4980,SELD,SPS,SPS1 )
Gene Full Name: selenophosphate synthetase 1
Band: 10p13
Quick LinksEntrez ID:22929; OMIM: 600902; Uniprot ID:SPS1_HUMAN; ENSEMBL ID: ENSG00000086475; HGNC ID: 19685
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body10 / 70761141
blastocyst19 / 62319304
fetus63 / 564012111
neonate1 / 3109732
infant0 / 236200 
juvenile5 / 5555689
adult132 / 193912168
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma1 / 1747557
breast (mammary gland) tumor15 / 94178159
cervical tumor6 / 34366174
chondrosarcoma4 / 8282348
colorectal tumor8 / 11424670
esophageal tumor0 / 172900 
gastrointestinal tumor11 / 11936992
germ cell tumor21 / 26384579
glioma10 / 10688393
head and neck tumor5 / 13630236
kidney tumor3 / 6895943
leukemia12 / 95842125
liver tumor3 / 9635931
lung tumor6 / 10312758
lymphoma11 / 71755153
non-neoplasia5 / 9725051
normal229 / 336030768
ovarian tumor3 / 7668239
pancreatic tumor3 / 10461628
primitive neuroectodermal tumor of the CNS7 / 12568055
prostate cancer3 / 10268029
retinoblastoma6 / 46356129
skin tumor9 / 12494972
soft tissue/muscle tissue tumor10 / 12519179
uterine tumor6 / 9025766
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites2 / 4001549
bladder1 / 2975733
blood9 / 12347872
bone12 / 71655167
bone marrow3 / 4880161
brain34 / 110098930
cervix7 / 48171145
connective tissue3 / 14925520
ear0 / 162120 
embryonic tissue49 / 215722227
esophagus0 / 202090 
eye22 / 211054104
heart11 / 89626122
intestine19 / 23447281
kidney12 / 21177756
larynx0 / 241450 
liver4 / 20774319
lung23 / 33697468
lymph7 / 44270158
lymph node6 / 9161065
mammary gland17 / 153271110
mouth2 / 6705229
muscle4 / 10771537
nerve0 / 157680 
ovary3 / 10205129
pancreas4 / 21481218
parathyroid3 / 20539146
pharynx0 / 413280 
pituitary gland3 / 16585180
placenta25 / 28082589
prostate7 / 18934536
salivary gland0 / 201550 
skin12 / 21057456
spleen0 / 539520 
stomach11 / 96619113
testis15 / 33044245
thymus6 / 8113173
thyroid2 / 4747342
tonsil1 / 1699958
trachea0 / 524130 
umbilical cord0 / 136800 
uterus17 / 23287872
vascular2 / 5178038
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 208940_at
Cell line Expression level Expression bar
721_B_lymphoblasts13.85
Adipocyte10.8
AdrenalCortex11.4
Adrenalgland9.35
Amygdala11.35
Appendix11.05
AtrioventricularNode8.85
BDCA4+_DentriticCells19.95
Bonemarrow11.05
BronchialEpithelialCells10.6
CD105+_Endothelial12.9
CD14+_Monocytes8.05
CD19+_BCells(neg._sel.)11.95
CD33+_Myeloid12.6
CD34+17.85
CD4+_Tcells11.9
CD56+_NKCells12.9
CD71+_EarlyErythroid9.25
CD8+_Tcells10.5
CardiacMyocytes15.1
Caudatenucleus9.45
Cerebellum9.55
CerebellumPeduncles17.35
CiliaryGanglion7.55
CingulateCortex10.75
Colorectaladenocarcinoma10.5
DorsalRootGanglion8.2
FetalThyroid26.75
Fetalbrain11.1
Fetalliver11
Fetallung13.85
GlobusPallidus7.95
Heart13.15
Hypothalamus13.9
Kidney8.95
Leukemia_chronicMyelogenousK-5628.15
Leukemia_promyelocytic-HL-609.4
Leukemialymphoblastic(MOLT-4)33
Liver13.8
Lung11.9
Lymphnode9.45
Lymphoma_burkitts(Daudi)14.55
Lymphoma_burkitts(Raji)13.45
MedullaOblongata9.5
OccipitalLobe9.75
OlfactoryBulb8.5
Ovary7.25
Pancreas8.7
PancreaticIslet10.4
ParietalLobe10.85
Pituitary12.9
Placenta10.2
Pons10
PrefrontalCortex13.05
Prostate12.7
Salivarygland8.7
SkeletalMuscle12.6
Skin8.3
SmoothMuscle12.4
Spinalcord10.35
SubthalamicNucleus9.5
SuperiorCervicalGanglion12.25
TemporalLobe8.9
Testis10.25
TestisGermCell11.65
TestisIntersitial9.3
TestisLeydigCell10.65
TestisSeminiferousTubule11.7
Thalamus9.2
Thymus13.25
Thyroid24.2
Tongue10.9
Tonsil11.2
Trachea9.1
TrigeminalGanglion10.4
Uterus9.4
UterusCorpus10.9
WholeBlood10.6
Wholebrain9.65
colon11
pineal_day13.52
pineal_night12.7
retina16.45
small_intestine10.55
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P150092
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala7.95 ± 0.2
Basal Forebrain8.05 ± 0.12
Basal Part of Pons7.88 ± 0.13
Cerebellar Cortex7.84 ± 0.14
Cerebellar Nuclei7.98 ± 0.22
Claustrum7.86 ± 0.19
Epithalamus8.28 ± 0.16
Frontal Lobe7.95 ± 0.19
Globus Pallidus8.21 ± 0.14
Hypothalamus8 ± 0.19
Insula7.95 ± 0.2
Limbic Lobe7.92 ± 0.16
Mesencephalon7.99 ± 0.19
Myelencephalon7.94 ± 0.19
Occipital Lobe7.92 ± 0.14
Parietal Lobe7.87 ± 0.18
Pontine Tegmentum7.9 ± 0.18
Striatum7.98 ± 0.15
Subthalamus7.83 ± 0.11
Temporal Lobe7.96 ± 0.18
Thalamus7.85 ± 0.14
White Matter8.04 ± 0.27
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Sephs1CBCerebellum0.41
0.65
Sephs1CTXCerebral cortex1.19
1.44
Sephs1HIPHippocampal region1.93
3.49
Sephs1HPFHippocampal formation1.29
2.28
Sephs1HYHypothalamus0.11
0.11
Sephs1LSXLateral septal complex0.03
0
Sephs1MBMidbrain0.25
0.44
Sephs1MYMedulla0.44
0.66
Sephs1OLFOlfactory bulb1.09
1.7
Sephs1PPons0.4
0.53
Sephs1PALPallidum0.12
0.17
Sephs1RHPRetrohippocampal region0.23
0.56
Sephs1sAMYStriatum-like amygdalar nuclei0.14
0.15
Sephs1STRStriatum0.32
0.47
Sephs1STRdStriatum dorsal region0.38
0.66
Sephs1STRvStriatum ventral region0.14
0.15
Sephs1THThalamus0.4
0.41
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00075206 15 284 298 NEVSFVIHNLPVLAK Peptide Atlas
SPS1_HUMAN_140 10 140 149 VMPLIIQGFK PRIDE
SPS1_HUMAN_249 31 249 279 TAAGLMHTFNAHAATDITGFGILGHAQNLAK PRIDE
SPS1_HUMAN_41 23 41 63 LLESLQENHFQEDEQFLGAVMPR PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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