AutismKB 2.0

Annotation Detail for DKK1


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Basic Information Top
Gene Symbol:DKK1 ( DKK-1,SK )
Gene Full Name: dickkopf homolog 1 (Xenopus laevis)
Band: 10q21.1
Quick LinksEntrez ID:22943; OMIM: 605189; Uniprot ID:DKK1_HUMAN; ENSEMBL ID: ENSG00000107984; HGNC ID: 2891
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst2 / 6231932
fetus3 / 5640125
neonate0 / 310970 
infant1 / 2362042
juvenile2 / 5555635
adult85 / 193912143
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma1 / 1747557
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma1 / 8282312
colorectal tumor1 / 1142468
esophageal tumor0 / 172900 
gastrointestinal tumor37 / 119369309
germ cell tumor4 / 26384515
glioma0 / 1068830 
head and neck tumor7 / 13630251
kidney tumor0 / 689590 
leukemia1 / 9584210
liver tumor17 / 96359176
lung tumor2 / 10312719
lymphoma0 / 717550 
non-neoplasia0 / 972500 
normal88 / 336030726
ovarian tumor0 / 766820 
pancreatic tumor14 / 104616133
primitive neuroectodermal tumor of the CNS7 / 12568055
prostate cancer6 / 10268058
retinoblastoma0 / 463560 
skin tumor1 / 1249498
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor2 / 9025722
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites3 / 4001574
bladder2 / 2975767
blood0 / 1234780 
bone2 / 7165527
bone marrow1 / 4880120
brain5 / 11009894
cervix0 / 481710 
connective tissue1 / 1492556
ear0 / 162120 
embryonic tissue2 / 2157229
esophagus0 / 202090 
eye0 / 2110540 
heart0 / 896260 
intestine25 / 234472106
kidney0 / 2117770 
larynx0 / 241450 
liver20 / 20774396
lung3 / 3369748
lymph0 / 442700 
lymph node2 / 9161021
mammary gland7 / 15327145
mouth1 / 6705214
muscle2 / 10771518
nerve0 / 157680 
ovary3 / 10205129
pancreas14 / 21481265
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta31 / 280825110
prostate8 / 18934542
salivary gland0 / 201550 
skin16 / 21057475
spleen0 / 539520 
stomach12 / 96619124
testis0 / 3304420 
thymus0 / 811310 
thyroid6 / 47473126
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus22 / 23287894
vascular1 / 5178019
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 204602_at
Cell line Expression level Expression bar
721_B_lymphoblasts7.25
Adipocyte1074.3
AdrenalCortex7.35
Adrenalgland5.45
Amygdala6.5
Appendix9.55
AtrioventricularNode8.6
BDCA4+_DentriticCells6.45
Bonemarrow6.7
BronchialEpithelialCells1178.65
CD105+_Endothelial6.4
CD14+_Monocytes6.6
CD19+_BCells(neg._sel.)6.55
CD33+_Myeloid8.2
CD34+7.95
CD4+_Tcells6.5
CD56+_NKCells7.35
CD71+_EarlyErythroid5.95
CD8+_Tcells5.55
CardiacMyocytes149.95
Caudatenucleus5.55
Cerebellum5.25
CerebellumPeduncles7.25
CiliaryGanglion5.8
CingulateCortex6.55
Colorectaladenocarcinoma6.3
DorsalRootGanglion6.1
FetalThyroid6.15
Fetalbrain6.25
Fetalliver5.9
Fetallung5.25
GlobusPallidus4.85
Heart9.25
Hypothalamus6.65
Kidney5.45
Leukemia_chronicMyelogenousK-5625.7
Leukemia_promyelocytic-HL-605.45
Leukemialymphoblastic(MOLT-4)5
Liver9.05
Lung6.85
Lymphnode5.35
Lymphoma_burkitts(Daudi)8
Lymphoma_burkitts(Raji)9.8
MedullaOblongata8.7
OccipitalLobe5.55
OlfactoryBulb4.9
Ovary5.55
Pancreas5.9
PancreaticIslet6.8
ParietalLobe6.8
Pituitary7.35
Placenta445.45
Pons6.3
PrefrontalCortex7.6
Prostate7.35
Salivarygland5.05
SkeletalMuscle8.6
Skin7.3
SmoothMuscle8.75
Spinalcord6.6
SubthalamicNucleus5.8
SuperiorCervicalGanglion14.55
TemporalLobe5.95
Testis5.4
TestisGermCell5.15
TestisIntersitial5.35
TestisLeydigCell6.3
TestisSeminiferousTubule5.4
Thalamus6.35
Thymus4.85
Thyroid7.75
Tongue6.65
Tonsil6.1
Trachea5.2
TrigeminalGanglion10.3
Uterus5.2
UterusCorpus6.4
WholeBlood6.75
Wholebrain5.1
colon6.2
pineal_day7.64
pineal_night7.52
retina7.575
small_intestine6.05
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_15473_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala3.28 ± 1.07
Basal Forebrain3.85 ± 0.82
Basal Part of Pons3.91 ± 0.25
Cerebellar Cortex3.1 ± 0.79
Cerebellar Nuclei4.11 ± 0.8
Claustrum3.57 ± 0.67
Epithalamus3.14 ± 0.6
Frontal Lobe3.34 ± 0.78
Globus Pallidus4.92 ± 0.27
Hypothalamus4.19 ± 0.6
Insula3.21 ± 0.69
Limbic Lobe2.99 ± 0.75
Mesencephalon3.61 ± 0.83
Myelencephalon3.25 ± 0.8
Occipital Lobe3.08 ± 0.66
Parietal Lobe3.54 ± 0.8
Pontine Tegmentum3.2 ± 0.88
Striatum2.5 ± 0.67
Subthalamus3.33 ± 0.69
Temporal Lobe3.23 ± 0.87
Thalamus3.17 ± 0.81
White Matter3.08 ± 0.67
Mouse Brain ISH
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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