AutismKB 2.0

Annotation Detail for TPX2


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Basic Information Top
Gene Symbol:TPX2 ( C20orf1,C20orf2,DIL-2,DIL2,FLS353,GD:C20orf1,HCA519,HCTP4,REPP86,p100 )
Gene Full Name: TPX2, microtubule-associated, homolog (Xenopus laevis)
Band: 20q11.21
Quick LinksEntrez ID:22974; OMIM: 605917; Uniprot ID:TPX2_HUMAN; ENSEMBL ID: ENSG00000088325; HGNC ID: 1249
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus4 / 5640127
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult27 / 193912113
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor1 / 9417810
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor5 / 11424643
esophageal tumor0 / 172900 
gastrointestinal tumor6 / 11936950
germ cell tumor3 / 26384511
glioma0 / 1068830 
head and neck tumor1 / 1363027
kidney tumor2 / 6895929
leukemia4 / 9584241
liver tumor1 / 9635910
lung tumor2 / 10312719
lymphoma3 / 7175541
non-neoplasia0 / 972500 
normal22 / 33603076
ovarian tumor3 / 7668239
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS1 / 1256807
prostate cancer1 / 1026809
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor2 / 12519115
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites2 / 4001549
bladder0 / 297570 
blood1 / 1234788
bone0 / 716550 
bone marrow0 / 488010 
brain2 / 11009891
cervix0 / 481710 
connective tissue1 / 1492556
ear1 / 1621261
embryonic tissue0 / 2157220 
esophagus0 / 202090 
eye0 / 2110540 
heart1 / 8962611
intestine7 / 23447229
kidney4 / 21177718
larynx0 / 241450 
liver5 / 20774324
lung2 / 3369745
lymph3 / 4427067
lymph node5 / 9161054
mammary gland1 / 1532716
mouth0 / 670520 
muscle1 / 1077159
nerve0 / 157680 
ovary4 / 10205139
pancreas0 / 2148120 
parathyroid0 / 205390 
pharynx1 / 4132824
pituitary gland0 / 165850 
placenta6 / 28082521
prostate1 / 1893455
salivary gland0 / 201550 
skin0 / 2105740 
spleen1 / 5395218
stomach2 / 9661920
testis3 / 3304429
thymus0 / 811310 
thyroid0 / 474730 
tonsil2 / 16999117
trachea0 / 524130 
umbilical cord0 / 136800 
uterus0 / 2328780 
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 210052_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts365.55
Adipocyte4.15
AdrenalCortex4.55
Adrenalgland3.6
Amygdala4.5
Appendix4.55
AtrioventricularNode3.3
BDCA4+_DentriticCells4.85
Bonemarrow25.95
BronchialEpithelialCells7.8
CD105+_Endothelial166.55
CD14+_Monocytes4.45
CD19+_BCells(neg._sel.)4.45
CD33+_Myeloid6.6
CD34+154.75
CD4+_Tcells4.5
CD56+_NKCells5.2
CD71+_EarlyErythroid268.85
CD8+_Tcells4.05
CardiacMyocytes84.35
Caudatenucleus3.85
Cerebellum3.4
CerebellumPeduncles4.75
CiliaryGanglion3.05
CingulateCortex4.4
Colorectaladenocarcinoma126.55
DorsalRootGanglion3.3
FetalThyroid4.15
Fetalbrain4.2
Fetalliver33.8
Fetallung3.75
GlobusPallidus3.15
Heart5.5
Hypothalamus4.55
Kidney3.45
Leukemia_chronicMyelogenousK-562104.65
Leukemia_promyelocytic-HL-6057.95
Leukemialymphoblastic(MOLT-4)346.35
Liver5.7
Lung4.65
Lymphnode3.7
Lymphoma_burkitts(Daudi)209.35
Lymphoma_burkitts(Raji)18.95
MedullaOblongata3.9
OccipitalLobe3.8
OlfactoryBulb3.25
Ovary2.85
Pancreas6.15
PancreaticIslet4.5
ParietalLobe4.5
Pituitary4.95
Placenta4.5
Pons4.05
PrefrontalCortex5.25
Prostate5.05
Salivarygland3.5
SkeletalMuscle5.15
Skin3.3
SmoothMuscle11.7
Spinalcord4.5
SubthalamicNucleus3.85
SuperiorCervicalGanglion6.3
TemporalLobe3.8
Testis28.05
TestisGermCell21.6
TestisIntersitial17.85
TestisLeydigCell18
TestisSeminiferousTubule17.3
Thalamus4.25
Thymus183.45
Thyroid5.25
Tongue5.75
Tonsil18.25
Trachea3.55
TrigeminalGanglion5.55
Uterus3.6
UterusCorpus3.8
WholeBlood4.65
Wholebrain3.7
colon5.5
pineal_day5.26
pineal_night5.14
retina5.275
small_intestine4.75
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_13390_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala3.26 ± 0.77
Basal Forebrain2.71 ± 0.79
Basal Part of Pons3.01 ± 0.73
Cerebellar Cortex2.69 ± 0.73
Cerebellar Nuclei2.78 ± 0.61
Claustrum3.51 ± 0.67
Epithalamus2.18 ± 0.89
Frontal Lobe2.74 ± 0.74
Globus Pallidus2.26 ± 0.54
Hypothalamus2.45 ± 0.61
Insula2.97 ± 0.8
Limbic Lobe2.89 ± 0.59
Mesencephalon2.72 ± 0.7
Myelencephalon2.79 ± 0.6
Occipital Lobe2.67 ± 0.61
Parietal Lobe2.69 ± 0.73
Pontine Tegmentum2.68 ± 0.75
Striatum3.06 ± 0.73
Subthalamus3.1 ± 0.6
Temporal Lobe2.81 ± 0.76
Thalamus2.6 ± 0.59
White Matter2.14 ± 0.53
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Tpx2CBCerebellum2.96
3.89
Tpx2CTXCerebral cortex5.61
4.22
Tpx2HIPHippocampal region2.62
2.86
Tpx2HPFHippocampal formation3.53
3.27
Tpx2HYHypothalamus0.35
0.4
Tpx2LSXLateral septal complex3.82
4.68
Tpx2MBMidbrain1.22
1.4
Tpx2MYMedulla4.97
5.82
Tpx2OLFOlfactory bulb6.14
5.4
Tpx2PPons1.87
2.09
Tpx2PALPallidum1.61
1.42
Tpx2RHPRetrohippocampal region5
3.84
Tpx2sAMYStriatum-like amygdalar nuclei0.96
0.73
Tpx2STRStriatum2.27
2.32
Tpx2STRdStriatum dorsal region1.99
2.2
Tpx2STRvStriatum ventral region3.31
2.55
Tpx2THThalamus7.18
8.98
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00002723 14 300 313 GCTIVKPFNLSQGK Peptide Atlas
TPX2_HUMAN_121 8 121 128 SLRLSAQK PRIDE
TPX2_HUMAN_145 14 145 158 CATPVIIDEILPSK PRIDE
TPX2_HUMAN_183 7 183 189 NASSPEK PRIDE
TPX2_HUMAN_289 8 289 296 KHPSSPAR PRIDE
TPX2_HUMAN_316 26 316 341 TFDETVSTYVPLAQQVEDFHKRTPNR PRIDE
TPX2_HUMAN_349 14 349 362 DDINLLPSKSSVTK PRIDE
TPX2_HUMAN_363 13 363 375 ICRDPQTPVLQTK PRIDE
TPX2_HUMAN_366 10 366 375 DPQTPVLQTK PRIDE
TPX2_HUMAN_45 14 45 58 LLGKNGTGGLFQGK PRIDE
TPX2_HUMAN_478 15 478 492 VLPITVPKSPAFALK PRIDE
TPX2_HUMAN_532 12 532 543 TVEICPFSFDSR PRIDE
TPX2_HUMAN_64 20 64 83 ANLQQAIVTPLKPVDNTYYK PRIDE
TPX2_HUMAN_645 22 645 666 KSVAEGLSGSLVQEPFQLATEK PRIDE
TPX2_HUMAN_646 21 646 666 SVAEGLSGSLVQEPFQLATEK PRIDE
TPX2_HUMAN_728 13 728 740 SSDQPLTVPVSPK PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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