AutismKB 2.0

Annotation Detail for NT5C2


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Basic Information Top
Gene Symbol:NT5C2 ( GMP,NT5B,PNT5,cN-II )
Gene Full Name: 5'-nucleotidase, cytosolic II
Band: 10q24.32-q24.33
Quick LinksEntrez ID:22978; OMIM: 600417; Uniprot ID:5NTC_HUMAN; ENSEMBL ID: ENSG00000076685; HGNC ID: 8022
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body4 / 7076156
blastocyst12 / 62319192
fetus121 / 564012214
neonate7 / 31097225
infant2 / 2362084
juvenile4 / 5555671
adult226 / 1939121116
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor10 / 94178106
cervical tumor1 / 3436629
chondrosarcoma3 / 8282336
colorectal tumor8 / 11424670
esophageal tumor2 / 17290115
gastrointestinal tumor14 / 119369117
germ cell tumor66 / 263845250
glioma1 / 1068839
head and neck tumor58 / 136302425
kidney tumor6 / 6895987
leukemia17 / 95842177
liver tumor5 / 9635951
lung tumor1 / 1031279
lymphoma9 / 71755125
non-neoplasia21 / 97250215
normal509 / 3360307151
ovarian tumor4 / 7668252
pancreatic tumor6 / 10461657
primitive neuroectodermal tumor of the CNS3 / 12568023
prostate cancer8 / 10268077
retinoblastoma2 / 4635643
skin tumor4 / 12494932
soft tissue/muscle tissue tumor4 / 12519131
uterine tumor10 / 90257110
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland0 / 331970 
ascites9 / 40015224
bladder3 / 29757100
blood23 / 123478186
bone2 / 7165527
bone marrow1 / 4880120
brain288 / 1100989261
cervix1 / 4817120
connective tissue22 / 149255147
ear0 / 162120 
embryonic tissue21 / 21572297
esophagus2 / 2020998
eye20 / 21105494
heart5 / 8962655
intestine18 / 23447276
kidney20 / 21177794
larynx2 / 2414582
liver7 / 20774333
lung21 / 33697462
lymph8 / 44270180
lymph node7 / 9161076
mammary gland14 / 15327191
mouth41 / 67052611
muscle9 / 10771583
nerve2 / 15768126
ovary5 / 10205148
pancreas9 / 21481241
parathyroid1 / 2053948
pharynx3 / 4132872
pituitary gland0 / 165850 
placenta39 / 280825138
prostate14 / 18934573
salivary gland1 / 2015549
skin17 / 21057480
spleen9 / 53952166
stomach4 / 9661941
testis171 / 330442517
thymus69 / 81131850
thyroid17 / 47473358
tonsil0 / 169990 
trachea93 / 524131774
umbilical cord0 / 136800 
uterus30 / 232878128
vascular9 / 51780173
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 209155_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts64.85
Adipocyte36.95
AdrenalCortex41.8
Adrenalgland28.4
Amygdala112.75
Appendix33.7
AtrioventricularNode28.2
BDCA4+_DentriticCells108.7
Bonemarrow40.15
BronchialEpithelialCells42.55
CD105+_Endothelial27.9
CD14+_Monocytes118.05
CD19+_BCells(neg._sel.)40.7
CD33+_Myeloid119.5
CD34+97.5
CD4+_Tcells57.9
CD56+_NKCells96.9
CD71+_EarlyErythroid15.1
CD8+_Tcells51.25
CardiacMyocytes41.8
Caudatenucleus37.55
Cerebellum22.2
CerebellumPeduncles33.5
CiliaryGanglion28.8
CingulateCortex44.4
Colorectaladenocarcinoma46.6
DorsalRootGanglion21.7
FetalThyroid64.1
Fetalbrain67.85
Fetalliver36.9
Fetallung63.3
GlobusPallidus23.7
Heart19.2
Hypothalamus123.85
Kidney26.2
Leukemia_chronicMyelogenousK-56239.15
Leukemia_promyelocytic-HL-6027.95
Leukemialymphoblastic(MOLT-4)34.7
Liver27.6
Lung32.65
Lymphnode40.05
Lymphoma_burkitts(Daudi)100.85
Lymphoma_burkitts(Raji)44.7
MedullaOblongata29.65
OccipitalLobe38.05
OlfactoryBulb39.7
Ovary27
Pancreas37.4
PancreaticIslet79.9
ParietalLobe25.5
Pituitary71.3
Placenta35.05
Pons24.6
PrefrontalCortex112.35
Prostate96.2
Salivarygland58.85
SkeletalMuscle39.05
Skin31.7
SmoothMuscle60.65
Spinalcord72.95
SubthalamicNucleus27.8
SuperiorCervicalGanglion34.7
TemporalLobe26.15
Testis26.65
TestisGermCell49.45
TestisIntersitial41.2
TestisLeydigCell34.4
TestisSeminiferousTubule45.85
Thalamus57.1
Thymus54.15
Thyroid376.65
Tongue53.75
Tonsil49.05
Trachea49.55
TrigeminalGanglion34.5
Uterus30.15
UterusCorpus26.55
WholeBlood257.6
Wholebrain23.85
colon106.15
pineal_day87.2
pineal_night85.14
retina117.55
small_intestine81.8
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P97906
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala9.07 ± 0.27
Basal Forebrain9.25 ± 0.36
Basal Part of Pons8.65 ± 0.19
Cerebellar Cortex8.88 ± 0.2
Cerebellar Nuclei9.08 ± 0.25
Claustrum9.01 ± 0.31
Epithalamus9.15 ± 0.24
Frontal Lobe8.88 ± 0.29
Globus Pallidus9.7 ± 0.21
Hypothalamus9.2 ± 0.24
Insula8.9 ± 0.27
Limbic Lobe8.97 ± 0.32
Mesencephalon9.27 ± 0.25
Myelencephalon9.02 ± 0.3
Occipital Lobe9.28 ± 0.3
Parietal Lobe9.04 ± 0.27
Pontine Tegmentum9.07 ± 0.27
Striatum9.17 ± 0.26
Subthalamus9.13 ± 0.17
Temporal Lobe8.89 ± 0.25
Thalamus9 ± 0.21
White Matter9.92 ± 0.38
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Nt5c2CBCerebellum4.88
6.15
Nt5c2CTXCerebral cortex2.21
1.66
Nt5c2HIPHippocampal region0.87
0.84
Nt5c2HPFHippocampal formation1.13
1.18
Nt5c2HYHypothalamus0.66
0.61
Nt5c2LSXLateral septal complex0.31
0.22
Nt5c2MBMidbrain1.39
2.02
Nt5c2MYMedulla1.12
1.13
Nt5c2OLFOlfactory bulb6.05
4.59
Nt5c2PPons1.25
1.01
Nt5c2PALPallidum0.42
0.38
Nt5c2RHPRetrohippocampal region1.52
1.48
Nt5c2sAMYStriatum-like amygdalar nuclei0.67
0.5
Nt5c2STRStriatum0.9
0.79
Nt5c2STRdStriatum dorsal region1.01
0.87
Nt5c2STRvStriatum ventral region0.94
0.92
Nt5c2THThalamus1.42
1.25
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00003823 29 314 342 IGTYTGPLQHGIVYSGGSSDTICDLLGAK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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