AutismKB 2.0

Annotation Detail for HMGXB3


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Basic Information Top
Gene Symbol:HMGXB3 ( HMGX3,KIAA0194,SMF )
Gene Full Name: HMG box domain containing 3
Band: 5q32
Quick LinksEntrez ID:22993; OMIM: NA; Uniprot ID:HMGX3_HUMAN; ENSEMBL ID: ENSG00000113716; HGNC ID: 28982
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body7 / 7076198
blastocyst5 / 6231980
fetus11 / 56401219
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult91 / 193912146
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma3 / 17475171
breast (mammary gland) tumor0 / 941780 
cervical tumor3 / 3436687
chondrosarcoma7 / 8282384
colorectal tumor10 / 11424687
esophageal tumor0 / 172900 
gastrointestinal tumor8 / 11936967
germ cell tumor8 / 26384530
glioma4 / 10688337
head and neck tumor10 / 13630273
kidney tumor4 / 6895958
leukemia6 / 9584262
liver tumor2 / 9635920
lung tumor4 / 10312738
lymphoma5 / 7175569
non-neoplasia2 / 9725020
normal83 / 336030724
ovarian tumor4 / 7668252
pancreatic tumor2 / 10461619
primitive neuroectodermal tumor of the CNS3 / 12568023
prostate cancer11 / 102680107
retinoblastoma3 / 4635664
skin tumor24 / 124949192
soft tissue/muscle tissue tumor8 / 12519163
uterine tumor9 / 9025799
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites6 / 40015149
bladder4 / 29757134
blood3 / 12347824
bone4 / 7165555
bone marrow2 / 4880140
brain10 / 11009899
cervix3 / 4817162
connective tissue3 / 14925520
ear0 / 162120 
embryonic tissue13 / 21572260
esophagus0 / 202090 
eye11 / 21105452
heart1 / 8962611
intestine15 / 23447263
kidney6 / 21177728
larynx0 / 241450 
liver2 / 2077439
lung19 / 33697456
lymph2 / 4427045
lymph node6 / 9161065
mammary gland3 / 15327119
mouth0 / 670520 
muscle3 / 10771527
nerve0 / 157680 
ovary4 / 10205139
pancreas5 / 21481223
parathyroid12 / 20539584
pharynx1 / 4132824
pituitary gland0 / 165850 
placenta6 / 28082521
prostate18 / 18934595
salivary gland6 / 20155297
skin29 / 210574137
spleen0 / 539520 
stomach0 / 966190 
testis5 / 33044215
thymus0 / 811310 
thyroid3 / 4747363
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus17 / 23287872
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 212431_at
Cell line Expression level Expression bar
721_B_lymphoblasts66.15
Adipocyte50.05
AdrenalCortex46.05
Adrenalgland47.4
Amygdala47.35
Appendix19.5
AtrioventricularNode31.95
BDCA4+_DentriticCells58.25
Bonemarrow66.2
BronchialEpithelialCells50.6
CD105+_Endothelial24.45
CD14+_Monocytes23.85
CD19+_BCells(neg._sel.)51.15
CD33+_Myeloid38.45
CD34+46.55
CD4+_Tcells66.35
CD56+_NKCells34.75
CD71+_EarlyErythroid46.4
CD8+_Tcells38.15
CardiacMyocytes50.75
Caudatenucleus38.35
Cerebellum66.1
CerebellumPeduncles73.2
CiliaryGanglion34.55
CingulateCortex46.5
Colorectaladenocarcinoma47.7
DorsalRootGanglion35.7
FetalThyroid43.35
Fetalbrain43.2
Fetalliver38.35
Fetallung37.35
GlobusPallidus43.15
Heart89.2
Hypothalamus56.2
Kidney39.55
Leukemia_chronicMyelogenousK-56264.25
Leukemia_promyelocytic-HL-6056.9
Leukemialymphoblastic(MOLT-4)47.5
Liver49.85
Lung42
Lymphnode61.9
Lymphoma_burkitts(Daudi)78.45
Lymphoma_burkitts(Raji)100.85
MedullaOblongata59.15
OccipitalLobe46.25
OlfactoryBulb58
Ovary37.15
Pancreas35.65
PancreaticIslet46.5
ParietalLobe60.3
Pituitary58.75
Placenta39.9
Pons45.9
PrefrontalCortex52.4
Prostate65.25
Salivarygland31.3
SkeletalMuscle89.15
Skin33.8
SmoothMuscle50.25
Spinalcord50.45
SubthalamicNucleus49.7
SuperiorCervicalGanglion46.25
TemporalLobe32.05
Testis58.95
TestisGermCell39.5
TestisIntersitial40.05
TestisLeydigCell41.1
TestisSeminiferousTubule41.1
Thalamus68.15
Thymus52.7
Thyroid53.3
Tongue49.65
Tonsil40.55
Trachea43.2
TrigeminalGanglion42.5
Uterus29.2
UterusCorpus33.6
WholeBlood33.2
Wholebrain37.45
colon52.35
pineal_day51.52
pineal_night45.88
retina86.95
small_intestine40.45
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_1071_PI416573500
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala4.86 ± 0.65
Basal Forebrain4.8 ± 0.36
Basal Part of Pons4.72 ± 0.48
Cerebellar Cortex4.41 ± 0.48
Cerebellar Nuclei4.3 ± 0.76
Claustrum5.29 ± 0.68
Epithalamus4.38 ± 0.67
Frontal Lobe4.41 ± 0.52
Globus Pallidus4.6 ± 0.55
Hypothalamus3.67 ± 0.4
Insula4.33 ± 0.6
Limbic Lobe4.93 ± 0.56
Mesencephalon4.57 ± 0.72
Myelencephalon4.65 ± 0.63
Occipital Lobe5.26 ± 0.62
Parietal Lobe4.66 ± 0.51
Pontine Tegmentum4.59 ± 0.64
Striatum5.45 ± 0.46
Subthalamus4.62 ± 0.43
Temporal Lobe4.49 ± 0.51
Thalamus4.96 ± 0.53
White Matter4.6 ± 0.73
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
A630042L21RikCBCerebellum6.65
6.68
A630042L21RikCTXCerebral cortex28.94
20.63
A630042L21RikHIPHippocampal region15.33
14.2
A630042L21RikHPFHippocampal formation16.03
13.88
A630042L21RikHYHypothalamus15.01
11.47
A630042L21RikLSXLateral septal complex16.3
10.34
A630042L21RikMBMidbrain8.02
6.85
A630042L21RikMYMedulla15.62
16.66
A630042L21RikOLFOlfactory bulb34.16
26.88
A630042L21RikPPons12.1
12.77
A630042L21RikPALPallidum17.51
15.03
A630042L21RikRHPRetrohippocampal region17.29
13.45
A630042L21RiksAMYStriatum-like amygdalar nuclei6.61
4.61
A630042L21RikSTRStriatum13.58
9.34
A630042L21RikSTRdStriatum dorsal region11.49
7.97
A630042L21RikSTRvStriatum ventral region25.01
16.14
A630042L21RikTHThalamus13.39
10.78
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
HMGX3_HUMAN_0 1 0 0 LHFLVAAVTTGAASRR PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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