AutismKB 2.0

Annotation Detail for ALDOC


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Basic Information Top
Gene Symbol:ALDOC ( ALDC )
Gene Full Name: aldolase C, fructose-bisphosphate
Band: 17q11.2
Quick LinksEntrez ID:230; OMIM: 103870; Uniprot ID:ALDOC_HUMAN; ENSEMBL ID: ENSG00000109107; HGNC ID: 418
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body2 / 7076128
blastocyst2 / 6231932
fetus38 / 56401267
neonate1 / 3109732
infant10 / 23620423
juvenile12 / 55556215
adult647 / 1939121333
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor2 / 12794156
bladder carcinoma1 / 1747557
breast (mammary gland) tumor7 / 9417874
cervical tumor5 / 34366145
chondrosarcoma8 / 8282396
colorectal tumor9 / 11424678
esophageal tumor6 / 17290347
gastrointestinal tumor13 / 119369108
germ cell tumor15 / 26384556
glioma49 / 106883458
head and neck tumor8 / 13630258
kidney tumor3 / 6895943
leukemia12 / 95842125
liver tumor6 / 9635962
lung tumor6 / 10312758
lymphoma16 / 71755222
non-neoplasia395 / 972504061
normal1661 / 3360307494
ovarian tumor9 / 76682117
pancreatic tumor2 / 10461619
primitive neuroectodermal tumor of the CNS25 / 125680198
prostate cancer5 / 10268048
retinoblastoma5 / 46356107
skin tumor1 / 1249498
soft tissue/muscle tissue tumor12 / 12519195
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue12 / 13106915
adrenal gland5 / 33197150
ascites8 / 40015199
bladder1 / 2975733
blood14 / 123478113
bone5 / 7165569
bone marrow8 / 48801163
brain2192 / 11009891990
cervix5 / 48171103
connective tissue4 / 14925526
ear0 / 162120 
embryonic tissue4 / 21572218
esophagus9 / 20209445
eye80 / 211054379
heart68 / 89626758
intestine20 / 23447285
kidney13 / 21177761
larynx7 / 24145289
liver12 / 20774357
lung15 / 33697444
lymph5 / 44270112
lymph node1 / 9161010
mammary gland11 / 15327171
mouth1 / 6705214
muscle2 / 10771518
nerve4 / 15768253
ovary13 / 102051127
pancreas4 / 21481218
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland1 / 1658560
placenta15 / 28082553
prostate8 / 18934542
salivary gland0 / 201550 
skin7 / 21057433
spleen3 / 5395255
stomach6 / 9661962
testis20 / 33044260
thymus2 / 8113124
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus14 / 23287860
vascular8 / 51780154
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 202022_at
Cell line Expression level Expression bar
721_B_lymphoblasts714.3
Adipocyte76.45
AdrenalCortex19.5
Adrenalgland26.65
Amygdala1680.25
Appendix33.9
AtrioventricularNode13.4
BDCA4+_DentriticCells6.3
Bonemarrow7.15
BronchialEpithelialCells91.2
CD105+_Endothelial4.15
CD14+_Monocytes5.95
CD19+_BCells(neg._sel.)24.45
CD33+_Myeloid5.45
CD34+5.15
CD4+_Tcells36.9
CD56+_NKCells17.3
CD71+_EarlyErythroid3.8
CD8+_Tcells27.2
CardiacMyocytes32.15
Caudatenucleus977.3
Cerebellum4999.1
CerebellumPeduncles3890.1
CiliaryGanglion114.75
CingulateCortex2287.5
Colorectaladenocarcinoma22.05
DorsalRootGanglion278.35
FetalThyroid21.35
Fetalbrain156.3
Fetalliver23.6
Fetallung30.95
GlobusPallidus1091.3
Heart664.75
Hypothalamus2445.05
Kidney13.4
Leukemia_chronicMyelogenousK-562224.2
Leukemia_promyelocytic-HL-60277.4
Leukemialymphoblastic(MOLT-4)221.05
Liver237.9
Lung33.6
Lymphnode25
Lymphoma_burkitts(Daudi)51.15
Lymphoma_burkitts(Raji)1010.7
MedullaOblongata1301
OccipitalLobe1712.6
OlfactoryBulb332.5
Ovary54.4
Pancreas15.55
PancreaticIslet52.75
ParietalLobe1533.15
Pituitary63.3
Placenta7.9
Pons956.65
PrefrontalCortex4222.15
Prostate39.15
Salivarygland9.55
SkeletalMuscle16.75
Skin25.85
SmoothMuscle91.3
Spinalcord2013.9
SubthalamicNucleus1281.15
SuperiorCervicalGanglion84.85
TemporalLobe1598.55
Testis24
TestisGermCell21.8
TestisIntersitial20.55
TestisLeydigCell31.7
TestisSeminiferousTubule26.45
Thalamus2182.1
Thymus34.8
Thyroid21
Tongue19.05
Tonsil42.75
Trachea33.8
TrigeminalGanglion58.5
Uterus18.9
UterusCorpus23.95
WholeBlood32.5
Wholebrain2023.95
colon13.1
pineal_day141.24
pineal_night56.32
retina1516.45
small_intestine22.4
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_9455_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala9 ± 0.36
Basal Forebrain8.98 ± 0.36
Basal Part of Pons9.83 ± 0.34
Cerebellar Cortex9.52 ± 0.52
Cerebellar Nuclei9.11 ± 0.39
Claustrum7.99 ± 0.6
Epithalamus8.35 ± 0.72
Frontal Lobe9.17 ± 0.63
Globus Pallidus8.81 ± 0.2
Hypothalamus9.07 ± 0.32
Insula8.98 ± 0.41
Limbic Lobe8.81 ± 0.62
Mesencephalon8.91 ± 0.56
Myelencephalon9.02 ± 0.66
Occipital Lobe8.83 ± 0.43
Parietal Lobe9.09 ± 0.58
Pontine Tegmentum9 ± 0.4
Striatum8.86 ± 0.5
Subthalamus8.81 ± 0.71
Temporal Lobe9.02 ± 0.53
Thalamus9.36 ± 0.41
White Matter7.26 ± 0.4
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
AldocCBCerebellum100
100
AldocCTXCerebral cortex86.98
95.02
AldocHIPHippocampal region86.96
100
AldocHPFHippocampal formation85.75
100
AldocHYHypothalamus100
100
AldocLSXLateral septal complex100
100
AldocMBMidbrain99.86
100
AldocMYMedulla69.37
100
AldocOLFOlfactory bulb85.13
97.52
AldocPPons90.14
100
AldocPALPallidum100
100
AldocRHPRetrohippocampal region83.47
94.94
AldocsAMYStriatum-like amygdalar nuclei84.87
100
AldocSTRStriatum81.29
88.03
AldocSTRdStriatum dorsal region78.01
87.13
AldocSTRvStriatum ventral region80.75
73.31
AldocTHThalamus82.63
100
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
ALDOC_HUMAN_0 0 0 0 TPSALAILENANVLAR PRIDE
ALDOC_HUMAN_102 7 102 108 GIVVGIK PRIDE
ALDOC_HUMAN_108 26 108 133 VDKGVVPLAGTDGETTTQGLDGLSER PRIDE
ALDOC_HUMAN_109 26 109 134 VDKGVVPLAGTDGETTTQGLDGLSER PRIDE
ALDOC_HUMAN_111 23 111 133 GVVPLAGTDGETTTQGLDGLSER PRIDE
ALDOC_HUMAN_112 23 112 134 GVVPLAGTDGETTTQGLDGLSER PRIDE
ALDOC_HUMAN_120 14 120 133 GETTTQGLDGLSER PRIDE
ALDOC_HUMAN_15 8 15 22 ELSDIALR PRIDE
ALDOC_HUMAN_157 16 157 172 TPSALAILENANVLAR PRIDE
ALDOC_HUMAN_158 16 158 173 TPSALAILENANVLAR PRIDE
ALDOC_HUMAN_173 28 173 200 YASICQQNGIVPIVEPEILPDGDHDLKR PRIDE
ALDOC_HUMAN_174 27 174 200 YASICQQNGIVPIVEPEILPDGDHDLK PRIDE
ALDOC_HUMAN_174 28 174 201 YASICQQNGIVPIVEPEILPDGDHDLKR PRIDE
ALDOC_HUMAN_209 7 209 215 VLAAVYK PRIDE
ALDOC_HUMAN_244 15 244 258 YTPEEIAMATVTALR PRIDE
ALDOC_HUMAN_259 31 259 289 RTVPPAVPGVTFLSGGQSEEEASFNLNAINR PRIDE
ALDOC_HUMAN_260 30 260 289 TVPPAVPGVTFLSGGQSEEEASFNLNAINR PRIDE
ALDOC_HUMAN_29 14 29 42 GILAADESVGSMAK PRIDE
ALDOC_HUMAN_290 15 290 304 CPLPRPWALTFSYGR PRIDE
ALDOC_HUMAN_304 11 304 314 ALQASALNAWR PRIDE
ALDOC_HUMAN_305 11 305 315 ALQASALNAWR PRIDE
ALDOC_HUMAN_319 12 319 330 DNAGAATEEFIK PRIDE
ALDOC_HUMAN_44 13 44 56 LSQIGVENTEENR PRIDE
ALDOC_HUMAN_44 14 44 57 LSQIGVENTEENRR PRIDE
ALDOC_HUMAN_45 12 45 56 SQIGVENTEENR PRIDE
ALDOC_HUMAN_60 9 60 68 QVLFSADDR PRIDE
ALDOC_HUMAN_61 9 61 69 QVLFSADDR PRIDE
PAp00001265 11 290 300 CPLPRPWALTF Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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