AutismKB 2.0

Annotation Detail for WDFY3


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Basic Information Top
Gene Symbol:WDFY3 ( ALFY,KIAA0993,MGC16461,ZFYVE25 )
Gene Full Name: WD repeat and FYVE domain containing 3
Band: 4q21.23
Quick LinksEntrez ID:23001; OMIM: NA; Uniprot ID:WDFY3_HUMAN; ENSEMBL ID: ENSG00000163625,ENSG00000250675,ENSG00000251089; HGNC ID: 20751
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body3 / 7076142
blastocyst5 / 6231980
fetus23 / 56401240
neonate0 / 310970 
infant0 / 236200 
juvenile1 / 5555617
adult105 / 193912154
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma0 / 174750 
breast (mammary gland) tumor6 / 9417863
cervical tumor0 / 343660 
chondrosarcoma4 / 8282348
colorectal tumor5 / 11424643
esophageal tumor0 / 172900 
gastrointestinal tumor6 / 11936950
germ cell tumor13 / 26384549
glioma7 / 10688365
head and neck tumor12 / 13630288
kidney tumor1 / 6895914
leukemia2 / 9584220
liver tumor2 / 9635920
lung tumor3 / 10312729
lymphoma0 / 717550 
non-neoplasia5 / 9725051
normal155 / 336030746
ovarian tumor5 / 7668265
pancreatic tumor3 / 10461628
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer4 / 10268038
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor3 / 12519123
uterine tumor5 / 9025755
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland1 / 3319730
ascites0 / 400150 
bladder1 / 2975733
blood2 / 12347816
bone1 / 7165513
bone marrow1 / 4880120
brain49 / 110098944
cervix0 / 481710 
connective tissue6 / 14925540
ear0 / 162120 
embryonic tissue9 / 21572241
esophagus0 / 202090 
eye5 / 21105423
heart0 / 896260 
intestine6 / 23447225
kidney24 / 211777113
larynx5 / 24145207
liver4 / 20774319
lung17 / 33697450
lymph0 / 442700 
lymph node1 / 9161010
mammary gland7 / 15327145
mouth0 / 670520 
muscle2 / 10771518
nerve2 / 15768126
ovary6 / 10205158
pancreas13 / 21481260
parathyroid1 / 2053948
pharynx2 / 4132848
pituitary gland0 / 165850 
placenta19 / 28082567
prostate5 / 18934526
salivary gland0 / 201550 
skin4 / 21057418
spleen0 / 539520 
stomach4 / 9661941
testis7 / 33044221
thymus0 / 811310 
thyroid6 / 47473126
tonsil0 / 169990 
trachea1 / 5241319
umbilical cord0 / 136800 
uterus11 / 23287847
vascular3 / 5178057
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 212602_at
Cell line Expression level Expression bar
721_B_lymphoblasts4.3
Adipocyte3.55
AdrenalCortex3.7
Adrenalgland3
Amygdala4.15
Appendix3.55
AtrioventricularNode2.65
BDCA4+_DentriticCells4.05
Bonemarrow3.5
BronchialEpithelialCells3.55
CD105+_Endothelial3.55
CD14+_Monocytes3.85
CD19+_BCells(neg._sel.)3.8
CD33+_Myeloid15.4
CD34+4.45
CD4+_Tcells3.75
CD56+_NKCells4.25
CD71+_EarlyErythroid3.3
CD8+_Tcells3.3
CardiacMyocytes4.5
Caudatenucleus3.25
Cerebellum3.85
CerebellumPeduncles5.05
CiliaryGanglion2.45
CingulateCortex4.3
Colorectaladenocarcinoma3.55
DorsalRootGanglion2.7
FetalThyroid3.5
Fetalbrain4.1
Fetalliver3.05
Fetallung3.1
GlobusPallidus2.65
Heart4.55
Hypothalamus4.85
Kidney4.95
Leukemia_chronicMyelogenousK-5623.25
Leukemia_promyelocytic-HL-603.1
Leukemialymphoblastic(MOLT-4)2.9
Liver4.7
Lung3.9
Lymphnode3.15
Lymphoma_burkitts(Daudi)4.5
Lymphoma_burkitts(Raji)4.9
MedullaOblongata6.55
OccipitalLobe7.45
OlfactoryBulb2.85
Ovary2.35
Pancreas2.9
PancreaticIslet3.8
ParietalLobe3.9
Pituitary8.1
Placenta4.55
Pons3.45
PrefrontalCortex5.35
Prostate4.2
Salivarygland2.9
SkeletalMuscle5.15
Skin2.8
SmoothMuscle4.1
Spinalcord3.8
SubthalamicNucleus3.3
SuperiorCervicalGanglion4
TemporalLobe3.3
Testis3.2
TestisGermCell3
TestisIntersitial2.95
TestisLeydigCell3.55
TestisSeminiferousTubule3.1
Thalamus3.6
Thymus2.85
Thyroid4.55
Tongue3.45
Tonsil3.45
Trachea3.1
TrigeminalGanglion3.5
Uterus2.9
UterusCorpus3.15
WholeBlood13.2
Wholebrain4.2
colon3.55
pineal_day7.42
pineal_night7.64
retina4.35
small_intestine3.5
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_6363_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala6.92 ± 0.32
Basal Forebrain7.02 ± 0.31
Basal Part of Pons6.69 ± 0.25
Cerebellar Cortex7.19 ± 0.2
Cerebellar Nuclei7.05 ± 0.26
Claustrum7.04 ± 0.24
Epithalamus7.15 ± 0.33
Frontal Lobe6.88 ± 0.29
Globus Pallidus7.22 ± 0.24
Hypothalamus6.59 ± 0.3
Insula6.82 ± 0.36
Limbic Lobe7.03 ± 0.3
Mesencephalon7.01 ± 0.27
Myelencephalon6.94 ± 0.33
Occipital Lobe7.12 ± 0.27
Parietal Lobe6.97 ± 0.31
Pontine Tegmentum7.03 ± 0.36
Striatum6.8 ± 0.31
Subthalamus6.81 ± 0.33
Temporal Lobe6.97 ± 0.28
Thalamus6.95 ± 0.31
White Matter8.1 ± 0.13
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Wdfy3CBCerebellum79.46
100
Wdfy3CTXCerebral cortex100
100
Wdfy3HIPHippocampal region64.81
100
Wdfy3HPFHippocampal formation80.69
100
Wdfy3HYHypothalamus100
100
Wdfy3LSXLateral septal complex100
100
Wdfy3MBMidbrain99.08
100
Wdfy3MYMedulla94.51
100
Wdfy3OLFOlfactory bulb100
100
Wdfy3PPons89.9
100
Wdfy3PALPallidum96.22
100
Wdfy3RHPRetrohippocampal region100
100
Wdfy3sAMYStriatum-like amygdalar nuclei100
93.65
Wdfy3STRStriatum81.93
69.66
Wdfy3STRdStriatum dorsal region66.05
54.66
Wdfy3STRvStriatum ventral region98.48
80.71
Wdfy3THThalamus100
100
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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