AutismKB 2.0

Annotation Detail for KLHDC10


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Basic Information Top
Gene Symbol:KLHDC10 ( KIAA0265,slim )
Gene Full Name: kelch domain containing 10
Band: 7q32.2
Quick LinksEntrez ID:23008; OMIM: NA; Uniprot ID:KLD10_HUMAN; ENSEMBL ID: ENSG00000128607,ENSG00000226848,ENSG00000237785; HGNC ID: 22194
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body4 / 7076156
blastocyst4 / 6231964
fetus59 / 564012104
neonate0 / 310970 
infant0 / 236200 
juvenile2 / 5555635
adult84 / 193912143
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma1 / 1747557
breast (mammary gland) tumor1 / 9417810
cervical tumor1 / 3436629
chondrosarcoma4 / 8282348
colorectal tumor3 / 11424626
esophageal tumor0 / 172900 
gastrointestinal tumor3 / 11936925
germ cell tumor4 / 26384515
glioma3 / 10688328
head and neck tumor5 / 13630236
kidney tumor0 / 689590 
leukemia1 / 9584210
liver tumor2 / 9635920
lung tumor5 / 10312748
lymphoma0 / 717550 
non-neoplasia6 / 9725061
normal179 / 336030753
ovarian tumor3 / 7668239
pancreatic tumor7 / 10461666
primitive neuroectodermal tumor of the CNS1 / 1256807
prostate cancer7 / 10268068
retinoblastoma1 / 4635621
skin tumor5 / 12494940
soft tissue/muscle tissue tumor8 / 12519163
uterine tumor4 / 9025744
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites2 / 4001549
bladder0 / 297570 
blood0 / 1234780 
bone3 / 7165541
bone marrow2 / 4880140
brain60 / 110098954
cervix1 / 4817120
connective tissue7 / 14925546
ear2 / 16212123
embryonic tissue17 / 21572278
esophagus0 / 202090 
eye12 / 21105456
heart10 / 89626111
intestine11 / 23447246
kidney16 / 21177775
larynx1 / 2414541
liver4 / 20774319
lung18 / 33697453
lymph0 / 442700 
lymph node9 / 9161098
mammary gland1 / 1532716
mouth3 / 6705244
muscle7 / 10771564
nerve2 / 15768126
ovary3 / 10205129
pancreas18 / 21481283
parathyroid4 / 20539194
pharynx1 / 4132824
pituitary gland0 / 165850 
placenta9 / 28082532
prostate13 / 18934568
salivary gland0 / 201550 
skin6 / 21057428
spleen1 / 5395218
stomach1 / 9661910
testis12 / 33044236
thymus1 / 8113112
thyroid1 / 4747321
tonsil0 / 169990 
trachea1 / 5241319
umbilical cord0 / 136800 
uterus8 / 23287834
vascular1 / 5178019
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 209254_at
Cell line Expression level Expression bar
721_B_lymphoblasts4.9
Adipocyte3.6
AdrenalCortex3.85
Adrenalgland3.65
Amygdala4.1
Appendix5.45
AtrioventricularNode3.2
BDCA4+_DentriticCells4.05
Bonemarrow3.55
BronchialEpithelialCells3.75
CD105+_Endothelial6.5
CD14+_Monocytes3.9
CD19+_BCells(neg._sel.)4
CD33+_Myeloid4.9
CD34+4.7
CD4+_Tcells3.95
CD56+_NKCells4.35
CD71+_EarlyErythroid4.95
CD8+_Tcells3.7
CardiacMyocytes4.6
Caudatenucleus3.3
Cerebellum3.05
CerebellumPeduncles4.25
CiliaryGanglion2.6
CingulateCortex3.9
Colorectaladenocarcinoma3.6
DorsalRootGanglion2.8
FetalThyroid3.65
Fetalbrain3.75
Fetalliver3.3
Fetallung3.05
GlobusPallidus2.7
Heart4.65
Hypothalamus4.45
Kidney3
Leukemia_chronicMyelogenousK-5623.7
Leukemia_promyelocytic-HL-603.2
Leukemialymphoblastic(MOLT-4)3
Liver6.8
Lung9
Lymphnode3.15
Lymphoma_burkitts(Daudi)4.7
Lymphoma_burkitts(Raji)5.05
MedullaOblongata3.45
OccipitalLobe3.35
OlfactoryBulb2.9
Ovary2.45
Pancreas2.95
PancreaticIslet4
ParietalLobe3.85
Pituitary4.4
Placenta3.9
Pons3.55
PrefrontalCortex4.55
Prostate7.3
Salivarygland3.05
SkeletalMuscle5.15
Skin2.9
SmoothMuscle4.2
Spinalcord3.95
SubthalamicNucleus3.3
SuperiorCervicalGanglion4.35
TemporalLobe3.7
Testis43.4
TestisGermCell28.6
TestisIntersitial29.65
TestisLeydigCell8.15
TestisSeminiferousTubule11.6
Thalamus3.75
Thymus3.05
Thyroid4.7
Tongue3.85
Tonsil3.6
Trachea3.2
TrigeminalGanglion3.7
Uterus4.3
UterusCorpus3.35
WholeBlood4
Wholebrain4.55
colon3.75
pineal_day4.64
pineal_night4.58
retina4.475
small_intestine3.65
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_32_P131090
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala3.53 ± 0.69
Basal Forebrain3.41 ± 0.39
Basal Part of Pons3.23 ± 0.49
Cerebellar Cortex3.11 ± 0.45
Cerebellar Nuclei3.38 ± 0.54
Claustrum3.77 ± 0.71
Epithalamus2.97 ± 0.41
Frontal Lobe3.21 ± 0.63
Globus Pallidus3.54 ± 0.58
Hypothalamus2.86 ± 0.49
Insula3.16 ± 0.5
Limbic Lobe3.39 ± 0.55
Mesencephalon3.25 ± 0.58
Myelencephalon3.34 ± 0.59
Occipital Lobe3.39 ± 0.63
Parietal Lobe3.29 ± 0.52
Pontine Tegmentum3.27 ± 0.61
Striatum3.4 ± 0.67
Subthalamus3.49 ± 0.42
Temporal Lobe3.23 ± 0.61
Thalamus3.2 ± 0.61
White Matter3.55 ± 0.52
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
2410127E18RikCBCerebellum24.63
30.15
2410127E18RikCTXCerebral cortex58.87
47.22
2410127E18RikHIPHippocampal region39.34
58.71
2410127E18RikHPFHippocampal formation49.45
58.68
2410127E18RikHYHypothalamus53.37
48.62
2410127E18RikLSXLateral septal complex19.64
15.8
2410127E18RikMBMidbrain49.96
50.17
2410127E18RikMYMedulla62.22
76.13
2410127E18RikOLFOlfactory bulb33.46
27.21
2410127E18RikPPons47.34
56.29
2410127E18RikPALPallidum49.95
51.33
2410127E18RikRHPRetrohippocampal region63.42
58.29
2410127E18RiksAMYStriatum-like amygdalar nuclei42.25
34.26
2410127E18RikSTRStriatum16.18
13.46
2410127E18RikSTRdStriatum dorsal region11.21
9.88
2410127E18RikSTRvStriatum ventral region15.2
11.2
2410127E18RikTHThalamus24.37
22.98
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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