AutismKB 2.0

Annotation Detail for CNOT1


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Basic Information Top
Gene Symbol:CNOT1 ( CDC39,DKFZp686E0722,DKFZp686O168,FLJ36492,FLJ90644,KIAA1007,NOT1,NOT1H )
Gene Full Name: CCR4-NOT transcription complex, subunit 1
Band: 16q21
Quick LinksEntrez ID:23019; OMIM: 604917; Uniprot ID:CNOT1_HUMAN; ENSEMBL ID: ENSG00000125107; HGNC ID: 7877
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body18 / 70761254
blastocyst28 / 62319449
fetus68 / 564012120
neonate7 / 31097225
infant3 / 23620127
juvenile5 / 5555689
adult326 / 1939121168
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma3 / 17475171
breast (mammary gland) tumor8 / 9417884
cervical tumor8 / 34366232
chondrosarcoma14 / 82823169
colorectal tumor29 / 114246253
esophageal tumor0 / 172900 
gastrointestinal tumor58 / 119369485
germ cell tumor60 / 263845227
glioma15 / 106883140
head and neck tumor32 / 136302234
kidney tumor9 / 68959130
leukemia13 / 95842135
liver tumor15 / 96359155
lung tumor16 / 103127155
lymphoma11 / 71755153
non-neoplasia8 / 9725082
normal409 / 3360307121
ovarian tumor15 / 76682195
pancreatic tumor3 / 10461628
primitive neuroectodermal tumor of the CNS7 / 12568055
prostate cancer12 / 102680116
retinoblastoma7 / 46356151
skin tumor20 / 124949160
soft tissue/muscle tissue tumor14 / 125191111
uterine tumor9 / 9025799
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland2 / 3319760
ascites12 / 40015299
bladder6 / 29757201
blood12 / 12347897
bone15 / 71655209
bone marrow5 / 48801102
brain97 / 110098988
cervix10 / 48171207
connective tissue9 / 14925560
ear2 / 16212123
embryonic tissue57 / 215722264
esophagus0 / 202090 
eye17 / 21105480
heart4 / 8962644
intestine50 / 234472213
kidney32 / 211777151
larynx7 / 24145289
liver27 / 207743129
lung42 / 336974124
lymph10 / 44270225
lymph node33 / 91610360
mammary gland23 / 153271150
mouth21 / 67052313
muscle18 / 107715167
nerve0 / 157680 
ovary15 / 102051146
pancreas6 / 21481227
parathyroid2 / 2053997
pharynx0 / 413280 
pituitary gland2 / 16585120
placenta38 / 280825135
prostate17 / 18934589
salivary gland2 / 2015599
skin23 / 210574109
spleen7 / 53952129
stomach44 / 96619455
testis130 / 330442393
thymus18 / 81131221
thyroid5 / 47473105
tonsil2 / 16999117
trachea14 / 52413267
umbilical cord8 / 13680584
uterus27 / 232878115
vascular3 / 5178057
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 200861_at
Cell line Expression level Expression bar
721_B_lymphoblasts85.3
Adipocyte23.85
AdrenalCortex28.45
Adrenalgland30.25
Amygdala28.3
Appendix30.9
AtrioventricularNode21.55
BDCA4+_DentriticCells44.95
Bonemarrow32.95
BronchialEpithelialCells25.45
CD105+_Endothelial30.95
CD14+_Monocytes22.05
CD19+_BCells(neg._sel.)29.8
CD33+_Myeloid41.2
CD34+35.3
CD4+_Tcells51.65
CD56+_NKCells32.6
CD71+_EarlyErythroid29.75
CD8+_Tcells51.7
CardiacMyocytes29.15
Caudatenucleus38.05
Cerebellum28.45
CerebellumPeduncles28.65
CiliaryGanglion17.9
CingulateCortex28.15
Colorectaladenocarcinoma26.55
DorsalRootGanglion22.8
FetalThyroid45.95
Fetalbrain33.6
Fetalliver27.95
Fetallung20.55
GlobusPallidus21.1
Heart27.7
Hypothalamus28.4
Kidney22.5
Leukemia_chronicMyelogenousK-56240.3
Leukemia_promyelocytic-HL-6049.8
Leukemialymphoblastic(MOLT-4)51.65
Liver28.8
Lung19.75
Lymphnode28.85
Lymphoma_burkitts(Daudi)47.35
Lymphoma_burkitts(Raji)33.45
MedullaOblongata27.2
OccipitalLobe28.1
OlfactoryBulb22.5
Ovary23.15
Pancreas16.2
PancreaticIslet32.65
ParietalLobe29.5
Pituitary67.25
Placenta23.25
Pons30.5
PrefrontalCortex33.9
Prostate22.75
Salivarygland22.3
SkeletalMuscle30.8
Skin21.75
SmoothMuscle26.55
Spinalcord30.5
SubthalamicNucleus22.15
SuperiorCervicalGanglion43.9
TemporalLobe30.55
Testis35.5
TestisGermCell54
TestisIntersitial32.1
TestisLeydigCell56.7
TestisSeminiferousTubule58.75
Thalamus29.7
Thymus34.05
Thyroid35.6
Tongue26.05
Tonsil41.05
Trachea25.9
TrigeminalGanglion30.1
Uterus19.85
UterusCorpus26.65
WholeBlood33.35
Wholebrain20.6
colon35.4
pineal_day41.22
pineal_night38.3
retina31.9
small_intestine33.5
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P193570
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala5.71 ± 0.3
Basal Forebrain5.98 ± 0.21
Basal Part of Pons5.8 ± 0.36
Cerebellar Cortex6.2 ± 0.15
Cerebellar Nuclei5.82 ± 0.42
Claustrum6.07 ± 0.63
Epithalamus6.35 ± 0.39
Frontal Lobe5.81 ± 0.34
Globus Pallidus5.77 ± 0.36
Hypothalamus5.74 ± 0.35
Insula5.82 ± 0.27
Limbic Lobe5.93 ± 0.38
Mesencephalon5.89 ± 0.34
Myelencephalon5.94 ± 0.36
Occipital Lobe6.1 ± 0.32
Parietal Lobe5.89 ± 0.31
Pontine Tegmentum5.87 ± 0.34
Striatum5.94 ± 0.38
Subthalamus5.59 ± 0.09
Temporal Lobe5.83 ± 0.33
Thalamus6.08 ± 0.32
White Matter6.3 ± 0.04
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Cnot1CBCerebellum26.56
36.48
Cnot1CTXCerebral cortex100
83.29
Cnot1HIPHippocampal region59.94
100
Cnot1HPFHippocampal formation75.29
100
Cnot1HYHypothalamus58.79
48.39
Cnot1LSXLateral septal complex61.83
43.57
Cnot1MBMidbrain33.51
29.66
Cnot1MYMedulla47.73
56.28
Cnot1OLFOlfactory bulb99.96
92.03
Cnot1PPons43.24
46.5
Cnot1PALPallidum55.46
54.15
Cnot1RHPRetrohippocampal region100
100
Cnot1sAMYStriatum-like amygdalar nuclei97.82
83.33
Cnot1STRStriatum80.74
62.01
Cnot1STRdStriatum dorsal region77.34
58.58
Cnot1STRvStriatum ventral region94.67
71.96
Cnot1THThalamus64.69
55.93
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00039740 16 624 639 CPSILGGLAPEKDQPK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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