AutismKB 2.0

Annotation Detail for KDM4B


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Basic Information Top
Gene Symbol:KDM4B ( FLJ44906,JMJD2B,KIAA0876 )
Gene Full Name: lysine (K)-specific demethylase 4B
Band: 19p13.3
Quick LinksEntrez ID:23030; OMIM: 609765; Uniprot ID:KDM4B_HUMAN; ENSEMBL ID: ENSG00000127663; HGNC ID: 29136
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body8 / 70761113
blastocyst4 / 6231964
fetus24 / 56401242
neonate0 / 310970 
infant1 / 2362042
juvenile0 / 555560 
adult114 / 193912158
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma0 / 174750 
breast (mammary gland) tumor26 / 94178276
cervical tumor1 / 3436629
chondrosarcoma2 / 8282324
colorectal tumor7 / 11424661
esophageal tumor0 / 172900 
gastrointestinal tumor5 / 11936941
germ cell tumor19 / 26384572
glioma25 / 106883233
head and neck tumor4 / 13630229
kidney tumor2 / 6895929
leukemia5 / 9584252
liver tumor1 / 9635910
lung tumor6 / 10312758
lymphoma5 / 7175569
non-neoplasia1 / 9725010
normal139 / 336030741
ovarian tumor18 / 76682234
pancreatic tumor2 / 10461619
primitive neuroectodermal tumor of the CNS5 / 12568039
prostate cancer11 / 102680107
retinoblastoma4 / 4635686
skin tumor2 / 12494916
soft tissue/muscle tissue tumor5 / 12519139
uterine tumor6 / 9025766
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland2 / 3319760
ascites2 / 4001549
bladder1 / 2975733
blood5 / 12347840
bone2 / 7165527
bone marrow11 / 48801225
brain47 / 110098942
cervix1 / 4817120
connective tissue2 / 14925513
ear0 / 162120 
embryonic tissue16 / 21572274
esophagus0 / 202090 
eye20 / 21105494
heart0 / 896260 
intestine16 / 23447268
kidney2 / 2117779
larynx0 / 241450 
liver2 / 2077439
lung17 / 33697450
lymph1 / 4427022
lymph node14 / 91610152
mammary gland30 / 153271195
mouth2 / 6705229
muscle2 / 10771518
nerve1 / 1576863
ovary22 / 102051215
pancreas9 / 21481241
parathyroid2 / 2053997
pharynx2 / 4132848
pituitary gland0 / 165850 
placenta5 / 28082517
prostate15 / 18934579
salivary gland0 / 201550 
skin7 / 21057433
spleen1 / 5395218
stomach1 / 9661910
testis6 / 33044218
thymus1 / 8113112
thyroid0 / 474730 
tonsil0 / 169990 
trachea1 / 5241319
umbilical cord0 / 136800 
uterus9 / 23287838
vascular2 / 5178038
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 212496_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts72.5
Adipocyte26.35
AdrenalCortex27.05
Adrenalgland34
Amygdala34.15
Appendix21.1
AtrioventricularNode6.8
BDCA4+_DentriticCells266.05
Bonemarrow21.95
BronchialEpithelialCells20.2
CD105+_Endothelial28.05
CD14+_Monocytes136.95
CD19+_BCells(neg._sel.)430.25
CD33+_Myeloid98.7
CD34+47.45
CD4+_Tcells30.2
CD56+_NKCells149.3
CD71+_EarlyErythroid20.9
CD8+_Tcells83.35
CardiacMyocytes18.25
Caudatenucleus14.05
Cerebellum35.1
CerebellumPeduncles30.8
CiliaryGanglion6.1
CingulateCortex18.55
Colorectaladenocarcinoma24.6
DorsalRootGanglion9.4
FetalThyroid102.15
Fetalbrain95.55
Fetalliver16
Fetallung42.3
GlobusPallidus6.6
Heart44.6
Hypothalamus34.5
Kidney14.1
Leukemia_chronicMyelogenousK-56230.05
Leukemia_promyelocytic-HL-6021.3
Leukemialymphoblastic(MOLT-4)27.1
Liver136.6
Lung47.35
Lymphnode25.75
Lymphoma_burkitts(Daudi)28.4
Lymphoma_burkitts(Raji)73.7
MedullaOblongata19.6
OccipitalLobe13.45
OlfactoryBulb10.9
Ovary13.1
Pancreas14.6
PancreaticIslet13.4
ParietalLobe12.45
Pituitary19.4
Placenta163.3
Pons6.5
PrefrontalCortex46.1
Prostate308.25
Salivarygland10.5
SkeletalMuscle10
Skin7.45
SmoothMuscle34.25
Spinalcord15.9
SubthalamicNucleus7.05
SuperiorCervicalGanglion12.45
TemporalLobe9.05
Testis45.55
TestisGermCell17.35
TestisIntersitial7.8
TestisLeydigCell19.3
TestisSeminiferousTubule21.05
Thalamus13.3
Thymus70.65
Thyroid187.2
Tongue10.75
Tonsil24.85
Trachea13.2
TrigeminalGanglion11.35
Uterus24.55
UterusCorpus10.2
WholeBlood211.65
Wholebrain46.9
colon22.5
pineal_day80.12
pineal_night96.4
retina56.775
small_intestine23.95
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_1232_PI416573500
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala5.08 ± 0.4
Basal Forebrain4.99 ± 0.24
Basal Part of Pons5.07 ± 0.51
Cerebellar Cortex5.51 ± 0.32
Cerebellar Nuclei4.95 ± 0.54
Claustrum4.47 ± 0.8
Epithalamus4.93 ± 0.52
Frontal Lobe5.06 ± 0.51
Globus Pallidus4.41 ± 0.46
Hypothalamus4.73 ± 0.53
Insula5.11 ± 0.32
Limbic Lobe5.21 ± 0.5
Mesencephalon5.07 ± 0.52
Myelencephalon5.17 ± 0.49
Occipital Lobe5.37 ± 0.41
Parietal Lobe5.09 ± 0.53
Pontine Tegmentum4.97 ± 0.57
Striatum4.87 ± 0.44
Subthalamus4.35 ± 0.83
Temporal Lobe5.22 ± 0.44
Thalamus5.26 ± 0.49
White Matter5.36 ± 0.49
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Jmjd2bCBCerebellum77.34
75.91
Jmjd2bCTXCerebral cortex100
100
Jmjd2bHIPHippocampal region100
100
Jmjd2bHPFHippocampal formation100
100
Jmjd2bHYHypothalamus100
100
Jmjd2bLSXLateral septal complex100
85.43
Jmjd2bMBMidbrain97.26
87.32
Jmjd2bMYMedulla78.14
78.56
Jmjd2bOLFOlfactory bulb100
100
Jmjd2bPPons89.57
91.43
Jmjd2bPALPallidum100
96.71
Jmjd2bRHPRetrohippocampal region100
98.08
Jmjd2bsAMYStriatum-like amygdalar nuclei100
100
Jmjd2bSTRStriatum100
100
Jmjd2bSTRdStriatum dorsal region100
100
Jmjd2bSTRvStriatum ventral region100
100
Jmjd2bTHThalamus100
100
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
KDM4B_HUMAN_89 11 89 99 QKKAMTVGEYR PRIDE
PAp00361112 20 538 557 AAFNQEHVSCQQAFEHFAQK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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