AutismKB 2.0

Annotation Detail for USP33


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Basic Information Top
Gene Symbol:USP33 ( KIAA1097,MGC16868,VDU1 )
Gene Full Name: ubiquitin specific peptidase 33
Band: 1p31.1
Quick LinksEntrez ID:23032; OMIM: NA; Uniprot ID:UBP33_HUMAN; ENSEMBL ID: ENSG00000077254; HGNC ID: 20059
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body1 / 7076114
blastocyst6 / 6231996
fetus37 / 56401265
neonate0 / 310970 
infant0 / 236200 
juvenile3 / 5555653
adult96 / 193912149
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma1 / 1747557
breast (mammary gland) tumor2 / 9417821
cervical tumor3 / 3436687
chondrosarcoma4 / 8282348
colorectal tumor1 / 1142468
esophageal tumor1 / 1729057
gastrointestinal tumor2 / 11936916
germ cell tumor33 / 263845125
glioma2 / 10688318
head and neck tumor6 / 13630244
kidney tumor5 / 6895972
leukemia8 / 9584283
liver tumor7 / 9635972
lung tumor3 / 10312729
lymphoma6 / 7175583
non-neoplasia1 / 9725010
normal189 / 336030756
ovarian tumor2 / 7668226
pancreatic tumor3 / 10461628
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer2 / 10268019
retinoblastoma4 / 4635686
skin tumor7 / 12494956
soft tissue/muscle tissue tumor9 / 12519171
uterine tumor6 / 9025766
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder1 / 2975733
blood7 / 12347856
bone7 / 7165597
bone marrow2 / 4880140
brain88 / 110098979
cervix4 / 4817183
connective tissue8 / 14925553
ear2 / 16212123
embryonic tissue13 / 21572260
esophagus1 / 2020949
eye8 / 21105437
heart1 / 8962611
intestine2 / 2344728
kidney11 / 21177751
larynx0 / 241450 
liver8 / 20774338
lung16 / 33697447
lymph1 / 4427022
lymph node12 / 91610130
mammary gland3 / 15327119
mouth3 / 6705244
muscle11 / 107715102
nerve1 / 1576863
ovary3 / 10205129
pancreas11 / 21481251
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland1 / 1658560
placenta11 / 28082539
prostate7 / 18934536
salivary gland0 / 201550 
skin7 / 21057433
spleen2 / 5395237
stomach3 / 9661931
testis32 / 33044296
thymus4 / 8113149
thyroid3 / 4747363
tonsil0 / 169990 
trachea18 / 52413343
umbilical cord0 / 136800 
uterus17 / 23287872
vascular5 / 5178096
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 212513_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts89.2
Adipocyte237.15
AdrenalCortex43.9
Adrenalgland58.65
Amygdala413.1
Appendix26.75
AtrioventricularNode15
BDCA4+_DentriticCells149.4
Bonemarrow19.15
BronchialEpithelialCells32.75
CD105+_Endothelial148.3
CD14+_Monocytes142.35
CD19+_BCells(neg._sel.)84.2
CD33+_Myeloid115.75
CD34+188.75
CD4+_Tcells220.75
CD56+_NKCells304.55
CD71+_EarlyErythroid93.8
CD8+_Tcells343.9
CardiacMyocytes36.85
Caudatenucleus62.7
Cerebellum27.75
CerebellumPeduncles98.85
CiliaryGanglion16.2
CingulateCortex230.4
Colorectaladenocarcinoma73.9
DorsalRootGanglion13.4
FetalThyroid39.75
Fetalbrain377.75
Fetalliver42.95
Fetallung83.6
GlobusPallidus69.5
Heart19.85
Hypothalamus366.05
Kidney14.15
Leukemia_chronicMyelogenousK-56249.85
Leukemia_promyelocytic-HL-6033.6
Leukemialymphoblastic(MOLT-4)69.9
Liver19.9
Lung24.1
Lymphnode125.45
Lymphoma_burkitts(Daudi)36.45
Lymphoma_burkitts(Raji)51.6
MedullaOblongata150.55
OccipitalLobe182.25
OlfactoryBulb67.75
Ovary12.15
Pancreas19.35
PancreaticIslet79.9
ParietalLobe130.4
Pituitary174.55
Placenta147.6
Pons75.65
PrefrontalCortex686.55
Prostate123.6
Salivarygland63.2
SkeletalMuscle22.35
Skin18.55
SmoothMuscle86.35
Spinalcord101.4
SubthalamicNucleus198.3
SuperiorCervicalGanglion33.6
TemporalLobe74.6
Testis13.7
TestisGermCell75.4
TestisIntersitial20.75
TestisLeydigCell26.2
TestisSeminiferousTubule29
Thalamus141.85
Thymus50.05
Thyroid268.6
Tongue28.9
Tonsil55.95
Trachea51.05
TrigeminalGanglion27.85
Uterus195.05
UterusCorpus21.7
WholeBlood227
Wholebrain146
colon142.3
pineal_day611.96
pineal_night645.32
retina223.6
small_intestine117.5
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P106
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala8.1 ± 0.23
Basal Forebrain8 ± 0.19
Basal Part of Pons8.38 ± 0.18
Cerebellar Cortex8.37 ± 0.25
Cerebellar Nuclei8.35 ± 0.4
Claustrum8.72 ± 0.31
Epithalamus8 ± 0.25
Frontal Lobe8.17 ± 0.32
Globus Pallidus7.8 ± 0.25
Hypothalamus8.14 ± 0.38
Insula8.19 ± 0.2
Limbic Lobe8.33 ± 0.32
Mesencephalon8.14 ± 0.28
Myelencephalon8.17 ± 0.28
Occipital Lobe8.49 ± 0.23
Parietal Lobe8.28 ± 0.29
Pontine Tegmentum8.23 ± 0.4
Striatum7.91 ± 0.26
Subthalamus8.39 ± 0.4
Temporal Lobe8.19 ± 0.27
Thalamus8.21 ± 0.23
White Matter8.06 ± 0.32
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Usp33CBCerebellum26.63
37.68
Usp33CTXCerebral cortex100
96.42
Usp33HIPHippocampal region60.74
100
Usp33HPFHippocampal formation67.03
92.09
Usp33HYHypothalamus50.53
46.46
Usp33LSXLateral septal complex37.62
31.88
Usp33MBMidbrain62.69
68.36
Usp33MYMedulla73.46
100
Usp33OLFOlfactory bulb58.37
54.63
Usp33PPons61.48
85.5
Usp33PALPallidum51.05
55.41
Usp33RHPRetrohippocampal region80.36
74.04
Usp33sAMYStriatum-like amygdalar nuclei42.95
34.83
Usp33STRStriatum47.35
36.94
Usp33STRdStriatum dorsal region51.09
39.69
Usp33STRvStriatum ventral region42.53
32.38
Usp33THThalamus63.71
65.42
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00041905 20 37 56 NHCPHLDSVGEITKEDLIQK Peptide Atlas
UBP33_HUMAN_138 9 138 146 QPHQIQENS PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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