AutismKB 2.0

Annotation Detail for TNIK


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Basic Information Top
Gene Symbol:TNIK ( - )
Gene Full Name: TRAF2 and NCK interacting kinase
Band: 3q26.2-q26.31
Quick LinksEntrez ID:23043; OMIM: 610005; Uniprot ID:TNIK_HUMAN; ENSEMBL ID: ENSG00000154310; HGNC ID: 30765
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body1 / 7076114
blastocyst0 / 623190 
fetus28 / 56401249
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult52 / 193912126
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma2 / 8282324
colorectal tumor8 / 11424670
esophageal tumor0 / 172900 
gastrointestinal tumor3 / 11936925
germ cell tumor16 / 26384560
glioma6 / 10688356
head and neck tumor2 / 13630214
kidney tumor1 / 6895914
leukemia0 / 958420 
liver tumor1 / 9635910
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia0 / 972500 
normal101 / 336030730
ovarian tumor0 / 766820 
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS1 / 1256807
prostate cancer2 / 10268019
retinoblastoma0 / 463560 
skin tumor4 / 12494932
soft tissue/muscle tissue tumor5 / 12519139
uterine tumor1 / 9025711
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites3 / 4001574
bladder0 / 297570 
blood1 / 1234788
bone3 / 7165541
bone marrow0 / 488010 
brain58 / 110098952
cervix0 / 481710 
connective tissue4 / 14925526
ear0 / 162120 
embryonic tissue4 / 21572218
esophagus0 / 202090 
eye0 / 2110540 
heart0 / 896260 
intestine8 / 23447234
kidney3 / 21177714
larynx0 / 241450 
liver3 / 20774314
lung10 / 33697429
lymph0 / 442700 
lymph node1 / 9161010
mammary gland2 / 15327113
mouth0 / 670520 
muscle1 / 1077159
nerve0 / 157680 
ovary0 / 1020510 
pancreas1 / 2148124
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta5 / 28082517
prostate2 / 18934510
salivary gland0 / 201550 
skin7 / 21057433
spleen1 / 5395218
stomach0 / 966190 
testis26 / 33044278
thymus0 / 811310 
thyroid3 / 4747363
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus5 / 23287821
vascular1 / 5178019
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 211828_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts15.5
Adipocyte4.6
AdrenalCortex5
Adrenalgland3.9
Amygdala9.85
Appendix4.85
AtrioventricularNode3.65
BDCA4+_DentriticCells4.9
Bonemarrow4.75
BronchialEpithelialCells4.4
CD105+_Endothelial4.85
CD14+_Monocytes4.95
CD19+_BCells(neg._sel.)4.7
CD33+_Myeloid6
CD34+6.7
CD4+_Tcells48.75
CD56+_NKCells23.5
CD71+_EarlyErythroid4.5
CD8+_Tcells60.7
CardiacMyocytes6.05
Caudatenucleus6.2
Cerebellum3.9
CerebellumPeduncles5.5
CiliaryGanglion3.4
CingulateCortex6
Colorectaladenocarcinoma4.9
DorsalRootGanglion3.8
FetalThyroid4.7
Fetalbrain7.35
Fetalliver4.15
Fetallung3.8
GlobusPallidus7.6
Heart6
Hypothalamus5.35
Kidney3.85
Leukemia_chronicMyelogenousK-5624.35
Leukemia_promyelocytic-HL-604.25
Leukemialymphoblastic(MOLT-4)3.55
Liver6.25
Lung5.35
Lymphnode4.05
Lymphoma_burkitts(Daudi)5.9
Lymphoma_burkitts(Raji)6.7
MedullaOblongata6.65
OccipitalLobe23.5
OlfactoryBulb3.8
Ovary3.15
Pancreas3.9
PancreaticIslet5.05
ParietalLobe6.85
Pituitary5.7
Placenta4.65
Pons4.95
PrefrontalCortex23.75
Prostate5.8
Salivarygland3.8
SkeletalMuscle5.5
Skin3.65
SmoothMuscle5.5
Spinalcord5.15
SubthalamicNucleus22.6
SuperiorCervicalGanglion5.65
TemporalLobe9.15
Testis4.2
TestisGermCell8.1
TestisIntersitial4.25
TestisLeydigCell4.8
TestisSeminiferousTubule4.2
Thalamus4.9
Thymus3.85
Thyroid5.95
Tongue4.65
Tonsil4.55
Trachea3.8
TrigeminalGanglion5
Uterus4
UterusCorpus4.25
WholeBlood5.35
Wholebrain4.75
colon5
pineal_day6.46
pineal_night6.64
retina8.5
small_intestine9.85
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P350576
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala7.93 ± 0.23
Basal Forebrain7.85 ± 0.15
Basal Part of Pons6.92 ± 0.23
Cerebellar Cortex7.07 ± 0.18
Cerebellar Nuclei6.69 ± 0.23
Claustrum7.49 ± 0.53
Epithalamus7.77 ± 0.3
Frontal Lobe7.52 ± 0.4
Globus Pallidus8.05 ± 0.2
Hypothalamus7.68 ± 0.19
Insula7.79 ± 0.28
Limbic Lobe7.52 ± 0.41
Mesencephalon7.64 ± 0.57
Myelencephalon7.6 ± 0.5
Occipital Lobe7.49 ± 0.33
Parietal Lobe7.53 ± 0.35
Pontine Tegmentum7.62 ± 0.37
Striatum8.47 ± 0.35
Subthalamus6.9 ± 0.58
Temporal Lobe7.52 ± 0.3
Thalamus7.6 ± 0.34
White Matter6.39 ± 0.2
Mouse Brain ISH
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00068554 15 618 632 GLSGFQEALNVTSHR Peptide Atlas
TNIK_HUMAN_372 14 372 385 QLEQQQRENEEHKR PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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