AutismKB 2.0

Annotation Detail for SETX


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Basic Information Top
Gene Symbol:SETX ( ALS4,AOA2,DKFZp781B151,FLJ12840,FLJ43459,KIAA0625,SCAR1,bA479K20.2 )
Gene Full Name: senataxin
Band: 9q34.13
Quick LinksEntrez ID:23064; OMIM: 608465; Uniprot ID:SETX_HUMAN; ENSEMBL ID: ENSG00000107290; HGNC ID: 445
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body3 / 7076142
blastocyst1 / 6231916
fetus70 / 564012124
neonate0 / 310970 
infant3 / 23620127
juvenile3 / 5555653
adult139 / 193912171
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor2 / 12794156
bladder carcinoma1 / 1747557
breast (mammary gland) tumor6 / 9417863
cervical tumor1 / 3436629
chondrosarcoma12 / 82823144
colorectal tumor8 / 11424670
esophageal tumor0 / 172900 
gastrointestinal tumor7 / 11936958
germ cell tumor24 / 26384590
glioma2 / 10688318
head and neck tumor12 / 13630288
kidney tumor3 / 6895943
leukemia8 / 9584283
liver tumor7 / 9635972
lung tumor3 / 10312729
lymphoma2 / 7175527
non-neoplasia9 / 9725092
normal280 / 336030783
ovarian tumor2 / 7668226
pancreatic tumor5 / 10461647
primitive neuroectodermal tumor of the CNS6 / 12568047
prostate cancer3 / 10268029
retinoblastoma2 / 4635643
skin tumor1 / 1249498
soft tissue/muscle tissue tumor8 / 12519163
uterine tumor3 / 9025733
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue2 / 13106152
adrenal gland2 / 3319760
ascites2 / 4001549
bladder0 / 297570 
blood10 / 12347880
bone5 / 7165569
bone marrow3 / 4880161
brain44 / 110098939
cervix1 / 4817120
connective tissue13 / 14925587
ear0 / 162120 
embryonic tissue12 / 21572255
esophagus0 / 202090 
eye14 / 21105466
heart3 / 8962633
intestine15 / 23447263
kidney14 / 21177766
larynx1 / 2414541
liver11 / 20774352
lung17 / 33697450
lymph0 / 442700 
lymph node23 / 91610251
mammary gland16 / 153271104
mouth4 / 6705259
muscle5 / 10771546
nerve1 / 1576863
ovary2 / 10205119
pancreas16 / 21481274
parathyroid2 / 2053997
pharynx5 / 41328120
pituitary gland1 / 1658560
placenta10 / 28082535
prostate10 / 18934552
salivary gland0 / 201550 
skin8 / 21057437
spleen5 / 5395292
stomach5 / 9661951
testis35 / 330442105
thymus2 / 8113124
thyroid9 / 47473189
tonsil0 / 169990 
trachea4 / 5241376
umbilical cord0 / 136800 
uterus14 / 23287860
vascular3 / 5178057
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 201965_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts30.35
Adipocyte6.25
AdrenalCortex6.15
Adrenalgland4.85
Amygdala6.4
Appendix6
AtrioventricularNode4.7
BDCA4+_DentriticCells103.75
Bonemarrow5.8
BronchialEpithelialCells5.7
CD105+_Endothelial10.45
CD14+_Monocytes85.55
CD19+_BCells(neg._sel.)71.75
CD33+_Myeloid155.25
CD34+17.55
CD4+_Tcells88.65
CD56+_NKCells154.45
CD71+_EarlyErythroid5.6
CD8+_Tcells96.1
CardiacMyocytes7.6
Caudatenucleus5.2
Cerebellum4.75
CerebellumPeduncles6.8
CiliaryGanglion4.2
CingulateCortex6.15
Colorectaladenocarcinoma7.3
DorsalRootGanglion4.6
FetalThyroid10.1
Fetalbrain5.6
Fetalliver5
Fetallung5
GlobusPallidus4.3
Heart7.65
Hypothalamus7.9
Kidney4.75
Leukemia_chronicMyelogenousK-5627.15
Leukemia_promyelocytic-HL-605.35
Leukemialymphoblastic(MOLT-4)4.95
Liver7.95
Lung6.75
Lymphnode12.2
Lymphoma_burkitts(Daudi)9.1
Lymphoma_burkitts(Raji)8.9
MedullaOblongata5.15
OccipitalLobe5.5
OlfactoryBulb7.05
Ovary3.9
Pancreas4.85
PancreaticIslet6.5
ParietalLobe6.45
Pituitary8
Placenta5.95
Pons5.7
PrefrontalCortex7.6
Prostate7.2
Salivarygland4.75
SkeletalMuscle6.8
Skin4.55
SmoothMuscle7.45
Spinalcord6.45
SubthalamicNucleus5.4
SuperiorCervicalGanglion6.75
TemporalLobe5.35
Testis6.25
TestisGermCell58.45
TestisIntersitial36.25
TestisLeydigCell24.25
TestisSeminiferousTubule34.6
Thalamus5.95
Thymus5.1
Thyroid15
Tongue5.95
Tonsil11.3
Trachea4.9
TrigeminalGanglion5.9
Uterus5
UterusCorpus5.4
WholeBlood32.35
Wholebrain5.15
colon6.15
pineal_day9.66
pineal_night7.92
retina7.85
small_intestine6
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P940921
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala7.68 ± 0.44
Basal Forebrain7.82 ± 0.21
Basal Part of Pons8.05 ± 0.18
Cerebellar Cortex8.22 ± 0.17
Cerebellar Nuclei8.11 ± 0.25
Claustrum7.63 ± 0.47
Epithalamus8.05 ± 0.27
Frontal Lobe7.95 ± 0.26
Globus Pallidus7.84 ± 0.28
Hypothalamus8.14 ± 0.25
Insula7.97 ± 0.31
Limbic Lobe7.8 ± 0.29
Mesencephalon7.93 ± 0.28
Myelencephalon7.9 ± 0.3
Occipital Lobe7.94 ± 0.26
Parietal Lobe7.96 ± 0.31
Pontine Tegmentum7.93 ± 0.33
Striatum7.75 ± 0.24
Subthalamus8.05 ± 0.22
Temporal Lobe7.9 ± 0.32
Thalamus7.9 ± 0.29
White Matter8.07 ± 0.24
Mouse Brain ISH
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
SETX_HUMAN_1036 8 1036 1043 QDKICLER PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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