AutismKB 2.0

Annotation Detail for FOXO1


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Basic Information Top
Gene Symbol:FOXO1 ( FKH1,FKHR,FOXO1A )
Gene Full Name: forkhead box O1
Band: 13q14.11
Quick LinksEntrez ID:2308; OMIM: 136533; Uniprot ID:FOXO1_HUMAN; ENSEMBL ID: ENSG00000150907; HGNC ID: 3819
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body1 / 7076114
blastocyst5 / 6231980
fetus45 / 56401279
neonate0 / 310970 
infant0 / 236200 
juvenile2 / 5555635
adult101 / 193912152
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor1 / 3436629
chondrosarcoma5 / 8282360
colorectal tumor4 / 11424635
esophageal tumor0 / 172900 
gastrointestinal tumor1 / 1193698
germ cell tumor4 / 26384515
glioma5 / 10688346
head and neck tumor5 / 13630236
kidney tumor1 / 6895914
leukemia9 / 9584293
liver tumor3 / 9635931
lung tumor2 / 10312719
lymphoma6 / 7175583
non-neoplasia3 / 9725030
normal175 / 336030752
ovarian tumor20 / 76682260
pancreatic tumor3 / 10461628
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer1 / 1026809
retinoblastoma1 / 4635621
skin tumor2 / 12494916
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor2 / 9025722
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood2 / 12347816
bone5 / 7165569
bone marrow1 / 4880120
brain24 / 110098921
cervix4 / 4817183
connective tissue7 / 14925546
ear4 / 16212246
embryonic tissue8 / 21572237
esophagus0 / 202090 
eye11 / 21105452
heart4 / 8962644
intestine12 / 23447251
kidney17 / 21177780
larynx0 / 241450 
liver6 / 20774328
lung12 / 33697435
lymph4 / 4427090
lymph node18 / 91610196
mammary gland2 / 15327113
mouth2 / 6705229
muscle3 / 10771527
nerve1 / 1576863
ovary20 / 102051195
pancreas9 / 21481241
parathyroid3 / 20539146
pharynx2 / 4132848
pituitary gland0 / 165850 
placenta6 / 28082521
prostate6 / 18934531
salivary gland0 / 201550 
skin8 / 21057437
spleen0 / 539520 
stomach2 / 9661920
testis9 / 33044227
thymus2 / 8113124
thyroid4 / 4747384
tonsil0 / 169990 
trachea1 / 5241319
umbilical cord0 / 136800 
uterus25 / 232878107
vascular4 / 5178077
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 202724_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts22.6
Adipocyte63.45
AdrenalCortex32.25
Adrenalgland17.8
Amygdala17.1
Appendix28.9
AtrioventricularNode38.3
BDCA4+_DentriticCells18.05
Bonemarrow19.7
BronchialEpithelialCells11.15
CD105+_Endothelial21.35
CD14+_Monocytes20.85
CD19+_BCells(neg._sel.)91.5
CD33+_Myeloid19.1
CD34+24.3
CD4+_Tcells104.05
CD56+_NKCells27.55
CD71+_EarlyErythroid12.15
CD8+_Tcells84.8
CardiacMyocytes29.95
Caudatenucleus19.3
Cerebellum10.4
CerebellumPeduncles25.7
CiliaryGanglion26.35
CingulateCortex23
Colorectaladenocarcinoma14.25
DorsalRootGanglion26.6
FetalThyroid51.1
Fetalbrain14.45
Fetalliver11.95
Fetallung29.6
GlobusPallidus16.4
Heart24.4
Hypothalamus21.25
Kidney13.7
Leukemia_chronicMyelogenousK-56212.05
Leukemia_promyelocytic-HL-6017
Leukemialymphoblastic(MOLT-4)9.35
Liver28.1
Lung59.45
Lymphnode34.5
Lymphoma_burkitts(Daudi)57.6
Lymphoma_burkitts(Raji)28.55
MedullaOblongata14.2
OccipitalLobe14.85
OlfactoryBulb56.1
Ovary136.85
Pancreas17.75
PancreaticIslet42.15
ParietalLobe20.4
Pituitary29.7
Placenta23.7
Pons19.9
PrefrontalCortex46.65
Prostate29.3
Salivarygland16.3
SkeletalMuscle36.15
Skin27.6
SmoothMuscle17.35
Spinalcord22.4
SubthalamicNucleus17.4
SuperiorCervicalGanglion27.15
TemporalLobe16.85
Testis15.95
TestisGermCell25.4
TestisIntersitial17.45
TestisLeydigCell20.7
TestisSeminiferousTubule19.25
Thalamus18.55
Thymus16.2
Thyroid91.9
Tongue28.2
Tonsil43.95
Trachea16.8
TrigeminalGanglion28.6
Uterus254.3
UterusCorpus38.45
WholeBlood52
Wholebrain15.35
colon42.15
pineal_day14.42
pineal_night14.88
retina27.575
small_intestine28.05
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P151426
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala8.98 ± 0.42
Basal Forebrain9.13 ± 0.27
Basal Part of Pons8.06 ± 0.33
Cerebellar Cortex8.13 ± 0.2
Cerebellar Nuclei8.58 ± 0.45
Claustrum8.36 ± 0.32
Epithalamus9.44 ± 0.42
Frontal Lobe8.55 ± 0.4
Globus Pallidus9.49 ± 0.3
Hypothalamus8.82 ± 0.56
Insula8.56 ± 0.23
Limbic Lobe8.47 ± 0.65
Mesencephalon8.94 ± 0.42
Myelencephalon8.73 ± 0.59
Occipital Lobe9 ± 0.65
Parietal Lobe8.61 ± 0.43
Pontine Tegmentum8.79 ± 0.52
Striatum10.23 ± 0.51
Subthalamus8.23 ± 0.36
Temporal Lobe8.46 ± 0.38
Thalamus8.98 ± 0.33
White Matter10.19 ± 0.34
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Foxo1CBCerebellum1.02
1.45
Foxo1CTXCerebral cortex0.53
0.63
Foxo1HIPHippocampal region7.71
9.4
Foxo1HPFHippocampal formation4.76
5.23
Foxo1HYHypothalamus0.24
0.23
Foxo1LSXLateral septal complex0.95
0.63
Foxo1MBMidbrain0.85
1.1
Foxo1MYMedulla0.53
0.82
Foxo1OLFOlfactory bulb1.7
1.55
Foxo1PPons0.43
0.51
Foxo1PALPallidum0.52
0.64
Foxo1RHPRetrohippocampal region0.98
0.81
Foxo1sAMYStriatum-like amygdalar nuclei2.25
1.99
Foxo1STRStriatum7.48
5.27
Foxo1STRdStriatum dorsal region10.06
6.87
Foxo1STRvStriatum ventral region5.08
3.95
Foxo1THThalamus1.74
1.77
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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