AutismKB 2.0

Annotation Detail for KDM4C


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Basic Information Top
Gene Symbol:KDM4C ( FLJ25949,GASC1,JHDM3C,JMJD2C,KIAA0780,bA146B14.1 )
Gene Full Name: lysine (K)-specific demethylase 4C
Band: 9p24.1
Quick LinksEntrez ID:23081; OMIM: 605469; Uniprot ID:KDM4C_HUMAN; ENSEMBL ID: ENSG00000107077; HGNC ID: 17071
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst1 / 6231916
fetus16 / 56401228
neonate1 / 3109732
infant0 / 236200 
juvenile1 / 5555617
adult349 / 1939121179
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor2 / 9417821
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor1 / 1142468
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor12 / 26384545
glioma0 / 1068830 
head and neck tumor5 / 13630236
kidney tumor0 / 689590 
leukemia5 / 9584252
liver tumor4 / 9635941
lung tumor1 / 1031279
lymphoma2 / 7175527
non-neoplasia0 / 972500 
normal143 / 336030742
ovarian tumor1 / 7668213
pancreatic tumor2 / 10461619
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer3 / 10268029
retinoblastoma0 / 463560 
skin tumor1 / 1249498
soft tissue/muscle tissue tumor275 / 1251912196
uterine tumor1 / 9025711
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue3 / 13106228
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood5 / 12347840
bone1 / 7165513
bone marrow1 / 4880120
brain44 / 110098939
cervix0 / 481710 
connective tissue273 / 1492551829
ear0 / 162120 
embryonic tissue1 / 2157224
esophagus0 / 202090 
eye5 / 21105423
heart0 / 896260 
intestine8 / 23447234
kidney1 / 2117774
larynx2 / 2414582
liver11 / 20774352
lung8 / 33697423
lymph1 / 4427022
lymph node9 / 9161098
mammary gland5 / 15327132
mouth1 / 6705214
muscle6 / 10771555
nerve0 / 157680 
ovary1 / 1020519
pancreas8 / 21481237
parathyroid1 / 2053948
pharynx1 / 4132824
pituitary gland0 / 165850 
placenta20 / 28082571
prostate6 / 18934531
salivary gland0 / 201550 
skin8 / 21057437
spleen3 / 5395255
stomach2 / 9661920
testis26 / 33044278
thymus8 / 8113198
thyroid2 / 4747342
tonsil0 / 169990 
trachea14 / 52413267
umbilical cord0 / 136800 
uterus4 / 23287817
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 209984_at
Cell line Expression level Expression bar
721_B_lymphoblasts11.35
Adipocyte4.6
AdrenalCortex4.85
Adrenalgland3.9
Amygdala4.8
Appendix4.8
AtrioventricularNode3.7
BDCA4+_DentriticCells29.25
Bonemarrow4.75
BronchialEpithelialCells4.5
CD105+_Endothelial21.8
CD14+_Monocytes25
CD19+_BCells(neg._sel.)66.6
CD33+_Myeloid29.5
CD34+18.4
CD4+_Tcells33.45
CD56+_NKCells40.3
CD71+_EarlyErythroid41.6
CD8+_Tcells34.95
CardiacMyocytes5.85
Caudatenucleus4.2
Cerebellum3.75
CerebellumPeduncles5.4
CiliaryGanglion3.35
CingulateCortex4.65
Colorectaladenocarcinoma4.7
DorsalRootGanglion3.5
FetalThyroid4.55
Fetalbrain4.55
Fetalliver4.1
Fetallung3.7
GlobusPallidus3.3
Heart5.9
Hypothalamus6.05
Kidney3.65
Leukemia_chronicMyelogenousK-5624.15
Leukemia_promyelocytic-HL-604.2
Leukemialymphoblastic(MOLT-4)3.65
Liver6.05
Lung5
Lymphnode3.95
Lymphoma_burkitts(Daudi)5.95
Lymphoma_burkitts(Raji)6.8
MedullaOblongata4.2
OccipitalLobe4.2
OlfactoryBulb3.65
Ovary3.05
Pancreas3.8
PancreaticIslet5.05
ParietalLobe4.8
Pituitary5.45
Placenta4.85
Pons4.4
PrefrontalCortex5.75
Prostate5.4
Salivarygland3.8
SkeletalMuscle5.3
Skin4.1
SmoothMuscle5.2
Spinalcord4.9
SubthalamicNucleus4.15
SuperiorCervicalGanglion5.35
TemporalLobe4.2
Testis3.9
TestisGermCell3.85
TestisIntersitial3.95
TestisLeydigCell4.5
TestisSeminiferousTubule3.95
Thalamus4.7
Thymus3.65
Thyroid5.7
Tongue4.6
Tonsil4.6
Trachea3.85
TrigeminalGanglion4.9
Uterus3.75
UterusCorpus4.1
WholeBlood5.85
Wholebrain3.8
colon5.25
pineal_day9.04
pineal_night12.26
retina6.6
small_intestine4.6
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P112201
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala7.18 ± 0.48
Basal Forebrain7.37 ± 0.15
Basal Part of Pons7.48 ± 0.45
Cerebellar Cortex7.9 ± 0.27
Cerebellar Nuclei7.57 ± 0.27
Claustrum7.07 ± 0.5
Epithalamus7.37 ± 0.33
Frontal Lobe7.36 ± 0.35
Globus Pallidus7.27 ± 0.37
Hypothalamus7.43 ± 0.45
Insula7.43 ± 0.25
Limbic Lobe7.36 ± 0.34
Mesencephalon7.3 ± 0.54
Myelencephalon7.35 ± 0.42
Occipital Lobe7.66 ± 0.36
Parietal Lobe7.4 ± 0.43
Pontine Tegmentum7.38 ± 0.34
Striatum7.22 ± 0.41
Subthalamus7.3 ± 0.47
Temporal Lobe7.36 ± 0.37
Thalamus7.33 ± 0.25
White Matter8.34 ± 0.47
Mouse Brain ISH
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
KDM4C_HUMAN_108 5 108 112 YCTPR PRIDE
KDM4C_HUMAN_113 9 113 121 YLDYEDLER PRIDE
KDM4C_HUMAN_16 12 16 27 IMTFRPSMEEFR PRIDE
KDM4C_HUMAN_450 16 450 465 LSGNSCLSTSVTEDIK PRIDE
KDM4C_HUMAN_476 24 476 499 SVPSISSEADDSIPLSSGYEKPEK PRIDE
KDM4C_HUMAN_500 10 500 509 SDPSELSWPK PRIDE
KDM4C_HUMAN_54 5 54 58 EWKPR PRIDE
KDM4C_HUMAN_557 10 557 566 VPSIAEGENK PRIDE
KDM4C_HUMAN_672 10 672 681 LDEVVTSEGK PRIDE
KDM4C_HUMAN_773 14 773 786 WAHVMCAVAVPEVR PRIDE
KDM4C_HUMAN_794 7 794 800 TQIDVGR PRIDE
KDM4C_HUMAN_920 10 920 929 DTFPEDIVSR PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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