AutismKB 2.0

Annotation Detail for FOXO3


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Basic Information Top
Gene Symbol:FOXO3 ( AF6q21,DKFZp781A0677,FKHRL1,FKHRL1P2,FOXO2,FOXO3A,MGC12739,MGC31925 )
Gene Full Name: forkhead box O3
Band: 6q21
Quick LinksEntrez ID:2309; OMIM: 602681; Uniprot ID:FOXO3_HUMAN; ENSEMBL ID: ENSG00000118689; HGNC ID: 3821
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body6 / 7076184
blastocyst0 / 623190 
fetus56 / 56401299
neonate2 / 3109764
infant1 / 2362042
juvenile7 / 55556125
adult147 / 193912175
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma0 / 174750 
breast (mammary gland) tumor6 / 9417863
cervical tumor6 / 34366174
chondrosarcoma4 / 8282348
colorectal tumor9 / 11424678
esophageal tumor1 / 1729057
gastrointestinal tumor4 / 11936933
germ cell tumor8 / 26384530
glioma13 / 106883121
head and neck tumor10 / 13630273
kidney tumor10 / 68959145
leukemia2 / 9584220
liver tumor1 / 9635910
lung tumor3 / 10312729
lymphoma4 / 7175555
non-neoplasia2 / 9725020
normal255 / 336030775
ovarian tumor11 / 76682143
pancreatic tumor2 / 10461619
primitive neuroectodermal tumor of the CNS20 / 125680159
prostate cancer4 / 10268038
retinoblastoma9 / 46356194
skin tumor4 / 12494932
soft tissue/muscle tissue tumor11 / 12519187
uterine tumor4 / 9025744
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue3 / 13106228
adrenal gland4 / 33197120
ascites2 / 4001549
bladder0 / 297570 
blood7 / 12347856
bone4 / 7165555
bone marrow0 / 488010 
brain87 / 110098979
cervix6 / 48171124
connective tissue6 / 14925540
ear5 / 16212308
embryonic tissue12 / 21572255
esophagus1 / 2020949
eye48 / 211054227
heart1 / 8962611
intestine14 / 23447259
kidney16 / 21177775
larynx2 / 2414582
liver10 / 20774348
lung21 / 33697462
lymph0 / 442700 
lymph node7 / 9161076
mammary gland9 / 15327158
mouth8 / 67052119
muscle19 / 107715176
nerve1 / 1576863
ovary16 / 102051156
pancreas6 / 21481227
parathyroid1 / 2053948
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta15 / 28082553
prostate14 / 18934573
salivary gland2 / 2015599
skin13 / 21057461
spleen3 / 5395255
stomach3 / 9661931
testis9 / 33044227
thymus5 / 8113161
thyroid4 / 4747384
tonsil0 / 169990 
trachea2 / 5241338
umbilical cord2 / 13680146
uterus13 / 23287855
vascular4 / 5178077
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 204131_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts65.8
Adipocyte133.45
AdrenalCortex34.25
Adrenalgland24.5
Amygdala38.65
Appendix70.3
AtrioventricularNode68.3
BDCA4+_DentriticCells101.25
Bonemarrow358.05
BronchialEpithelialCells68.05
CD105+_Endothelial229.3
CD14+_Monocytes192.55
CD19+_BCells(neg._sel.)59.2
CD33+_Myeloid310.35
CD34+220.4
CD4+_Tcells78.7
CD56+_NKCells182.35
CD71+_EarlyErythroid1261.1
CD8+_Tcells92.25
CardiacMyocytes20.7
Caudatenucleus14.2
Cerebellum107.45
CerebellumPeduncles203.9
CiliaryGanglion48.5
CingulateCortex120.3
Colorectaladenocarcinoma26.1
DorsalRootGanglion38.75
FetalThyroid134.55
Fetalbrain40.6
Fetalliver86.2
Fetallung71.25
GlobusPallidus53.4
Heart8.95
Hypothalamus16.35
Kidney31.05
Leukemia_chronicMyelogenousK-5628.35
Leukemia_promyelocytic-HL-609.05
Leukemialymphoblastic(MOLT-4)9.8
Liver48.6
Lung354.1
Lymphnode13.3
Lymphoma_burkitts(Daudi)10.85
Lymphoma_burkitts(Raji)15.5
MedullaOblongata76.2
OccipitalLobe64.65
OlfactoryBulb187.2
Ovary88.35
Pancreas99.25
PancreaticIslet105.55
ParietalLobe115.15
Pituitary50.9
Placenta81.55
Pons70.65
PrefrontalCortex395.6
Prostate378.35
Salivarygland93.15
SkeletalMuscle240.7
Skin39.25
SmoothMuscle37.5
Spinalcord10.2
SubthalamicNucleus87.9
SuperiorCervicalGanglion39.55
TemporalLobe69.45
Testis50.55
TestisGermCell115.1
TestisIntersitial29.85
TestisLeydigCell38.55
TestisSeminiferousTubule61
Thalamus28.1
Thymus124.6
Thyroid19
Tongue68.55
Tonsil48.15
Trachea78.35
TrigeminalGanglion78.15
Uterus139
UterusCorpus103.45
WholeBlood44.6
Wholebrain84.55
colon69
pineal_day81.76
pineal_night93.26
retina156.6
small_intestine62.1
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_32_P102062
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala7.01 ± 0.24
Basal Forebrain7.29 ± 0.25
Basal Part of Pons7.42 ± 0.26
Cerebellar Cortex7.42 ± 0.16
Cerebellar Nuclei6.89 ± 0.3
Claustrum6.87 ± 0.37
Epithalamus7.07 ± 0.32
Frontal Lobe6.96 ± 0.31
Globus Pallidus6.66 ± 0.26
Hypothalamus7.06 ± 0.36
Insula6.94 ± 0.41
Limbic Lobe6.93 ± 0.28
Mesencephalon7.06 ± 0.38
Myelencephalon7.11 ± 0.32
Occipital Lobe7.52 ± 0.23
Parietal Lobe7.26 ± 0.27
Pontine Tegmentum7.04 ± 0.31
Striatum6.75 ± 0.29
Subthalamus6.94 ± 0.04
Temporal Lobe7.14 ± 0.3
Thalamus7.26 ± 0.31
White Matter6.94 ± 0.17
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Foxo3aCBCerebellum93.29
100
Foxo3aCTXCerebral cortex100
81.85
Foxo3aHIPHippocampal region49.6
43.59
Foxo3aHPFHippocampal formation67.27
48.3
Foxo3aHYHypothalamus40.87
16.19
Foxo3aLSXLateral septal complex22.02
7.67
Foxo3aMBMidbrain49.76
22.04
Foxo3aMYMedulla54.25
31.47
Foxo3aOLFOlfactory bulb100
64.37
Foxo3aPPons53.17
29.44
Foxo3aPALPallidum50.38
24.11
Foxo3aRHPRetrohippocampal region96.03
55.21
Foxo3asAMYStriatum-like amygdalar nuclei98.57
41.52
Foxo3aSTRStriatum100
50.11
Foxo3aSTRdStriatum dorsal region100
58.16
Foxo3aSTRvStriatum ventral region98.21
41.29
Foxo3aTHThalamus70.56
34.44
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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