AutismKB 2.0

Annotation Detail for TNRC6B


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Basic Information Top
Gene Symbol:TNRC6B ( KIAA1093 )
Gene Full Name: trinucleotide repeat containing 6B
Band: 22q13.1
Quick LinksEntrez ID:23112; OMIM: 610740; Uniprot ID:TNR6B_HUMAN; ENSEMBL ID: ENSG00000100354; HGNC ID: 29190
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body2 / 7076128
blastocyst4 / 6231964
fetus56 / 56401299
neonate0 / 310970 
infant2 / 2362084
juvenile7 / 55556125
adult117 / 193912160
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor5 / 9417853
cervical tumor0 / 343660 
chondrosarcoma4 / 8282348
colorectal tumor7 / 11424661
esophageal tumor0 / 172900 
gastrointestinal tumor1 / 1193698
germ cell tumor10 / 26384537
glioma2 / 10688318
head and neck tumor5 / 13630236
kidney tumor2 / 6895929
leukemia10 / 95842104
liver tumor6 / 9635962
lung tumor3 / 10312729
lymphoma2 / 7175527
non-neoplasia12 / 97250123
normal185 / 336030755
ovarian tumor3 / 7668239
pancreatic tumor1 / 1046169
primitive neuroectodermal tumor of the CNS2 / 12568015
prostate cancer8 / 10268077
retinoblastoma1 / 4635621
skin tumor3 / 12494924
soft tissue/muscle tissue tumor2 / 12519115
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland1 / 3319730
ascites0 / 400150 
bladder0 / 297570 
blood10 / 12347880
bone3 / 7165541
bone marrow2 / 4880140
brain33 / 110098929
cervix0 / 481710 
connective tissue7 / 14925546
ear0 / 162120 
embryonic tissue6 / 21572227
esophagus0 / 202090 
eye29 / 211054137
heart4 / 8962644
intestine14 / 23447259
kidney8 / 21177737
larynx1 / 2414541
liver12 / 20774357
lung18 / 33697453
lymph1 / 4427022
lymph node14 / 91610152
mammary gland9 / 15327158
mouth5 / 6705274
muscle8 / 10771574
nerve4 / 15768253
ovary3 / 10205129
pancreas7 / 21481232
parathyroid1 / 2053948
pharynx1 / 4132824
pituitary gland3 / 16585180
placenta0 / 2808250 
prostate14 / 18934573
salivary gland0 / 201550 
skin6 / 21057428
spleen2 / 5395237
stomach1 / 9661910
testis8 / 33044224
thymus3 / 8113136
thyroid3 / 4747363
tonsil0 / 169990 
trachea1 / 5241319
umbilical cord0 / 136800 
uterus2 / 2328788
vascular1 / 5178019
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 213254_at
Cell line Expression level Expression bar
721_B_lymphoblasts28.9
Adipocyte19.95
AdrenalCortex19.65
Adrenalgland20.25
Amygdala13.35
Appendix20.75
AtrioventricularNode11.15
BDCA4+_DentriticCells34.2
Bonemarrow19.35
BronchialEpithelialCells12.65
CD105+_Endothelial28.4
CD14+_Monocytes25.25
CD19+_BCells(neg._sel.)50
CD33+_Myeloid53.15
CD34+40.6
CD4+_Tcells116.05
CD56+_NKCells59
CD71+_EarlyErythroid79.55
CD8+_Tcells104.75
CardiacMyocytes17
Caudatenucleus11.1
Cerebellum14.65
CerebellumPeduncles20.7
CiliaryGanglion11.75
CingulateCortex27.45
Colorectaladenocarcinoma10.95
DorsalRootGanglion12.95
FetalThyroid19.15
Fetalbrain20.2
Fetalliver15.9
Fetallung12.15
GlobusPallidus23
Heart16.05
Hypothalamus11.8
Kidney11.6
Leukemia_chronicMyelogenousK-5629.75
Leukemia_promyelocytic-HL-6014.3
Leukemialymphoblastic(MOLT-4)9.8
Liver15.85
Lung13.55
Lymphnode11.8
Lymphoma_burkitts(Daudi)15.85
Lymphoma_burkitts(Raji)23.35
MedullaOblongata28.75
OccipitalLobe23
OlfactoryBulb20.75
Ovary10.7
Pancreas13.2
PancreaticIslet16.15
ParietalLobe19.05
Pituitary51
Placenta11.85
Pons19.35
PrefrontalCortex65.25
Prostate57.1
Salivarygland20.9
SkeletalMuscle22.95
Skin15.5
SmoothMuscle13
Spinalcord9.25
SubthalamicNucleus20.9
SuperiorCervicalGanglion16.85
TemporalLobe25.15
Testis14.15
TestisGermCell19.2
TestisIntersitial26.15
TestisLeydigCell20.95
TestisSeminiferousTubule31.55
Thalamus12.15
Thymus20.8
Thyroid17.3
Tongue16.95
Tonsil22.75
Trachea17.85
TrigeminalGanglion16.1
Uterus29.9
UterusCorpus16.7
WholeBlood28.35
Wholebrain15.55
colon15.35
pineal_day72.74
pineal_night71.1
retina27.2
small_intestine21.35
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P6490
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala8.18 ± 0.22
Basal Forebrain8.25 ± 0.13
Basal Part of Pons8.08 ± 0.21
Cerebellar Cortex8.56 ± 0.18
Cerebellar Nuclei8 ± 0.26
Claustrum8.35 ± 0.39
Epithalamus8.54 ± 0.27
Frontal Lobe8.22 ± 0.26
Globus Pallidus7.78 ± 0.08
Hypothalamus8.19 ± 0.22
Insula8.29 ± 0.26
Limbic Lobe8.28 ± 0.34
Mesencephalon8.32 ± 0.32
Myelencephalon8.27 ± 0.29
Occipital Lobe8.64 ± 0.24
Parietal Lobe8.29 ± 0.26
Pontine Tegmentum8.27 ± 0.27
Striatum8.14 ± 0.21
Subthalamus8.36 ± 0.26
Temporal Lobe8.31 ± 0.23
Thalamus8.3 ± 0.26
White Matter8.4 ± 0.11
Mouse Brain ISH
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00011603 19 592 610 SYRPTHPDCQAVLQTLLSR Peptide Atlas
TNR6B_HUMAN_1054 6 1054 1059 FNDIMR PRIDE
TNR6B_HUMAN_1197 9 1197 1205 QQQEQQLAR PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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