AutismKB 2.0

Annotation Detail for HIC2


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Basic Information Top
Gene Symbol:HIC2 ( HRG22,KIAA1020,ZBTB30,ZNF907 )
Gene Full Name: hypermethylated in cancer 2
Band: 22q11.21
Quick LinksEntrez ID:23119; OMIM: 607712; Uniprot ID:HIC2_HUMAN; ENSEMBL ID: ENSG00000169635; HGNC ID: 18595
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body2 / 7076128
blastocyst2 / 6231932
fetus42 / 56401274
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult35 / 193912118
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor1 / 9417810
cervical tumor1 / 3436629
chondrosarcoma1 / 8282312
colorectal tumor2 / 11424617
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor26 / 26384598
glioma2 / 10688318
head and neck tumor0 / 1363020 
kidney tumor1 / 6895914
leukemia0 / 958420 
liver tumor0 / 963590 
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia2 / 9725020
normal93 / 336030727
ovarian tumor0 / 766820 
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor2 / 12494916
soft tissue/muscle tissue tumor3 / 12519123
uterine tumor3 / 9025733
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland0 / 331970 
ascites0 / 400150 
bladder1 / 2975733
blood1 / 1234788
bone0 / 716550 
bone marrow0 / 488010 
brain13 / 110098911
cervix1 / 4817120
connective tissue2 / 14925513
ear1 / 1621261
embryonic tissue6 / 21572227
esophagus0 / 202090 
eye10 / 21105447
heart6 / 8962666
intestine5 / 23447221
kidney4 / 21177718
larynx0 / 241450 
liver0 / 2077430 
lung14 / 33697441
lymph0 / 442700 
lymph node0 / 916100 
mammary gland1 / 1532716
mouth0 / 670520 
muscle2 / 10771518
nerve0 / 157680 
ovary0 / 1020510 
pancreas4 / 21481218
parathyroid1 / 2053948
pharynx0 / 413280 
pituitary gland1 / 1658560
placenta19 / 28082567
prostate0 / 1893450 
salivary gland0 / 201550 
skin2 / 2105749
spleen1 / 5395218
stomach0 / 966190 
testis11 / 33044233
thymus4 / 8113149
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus5 / 23287821
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 216911_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts9.95
Adipocyte11.05
AdrenalCortex12.4
Adrenalgland9.8
Amygdala11.45
Appendix11
AtrioventricularNode9.75
BDCA4+_DentriticCells10.25
Bonemarrow11.75
BronchialEpithelialCells10.05
CD105+_Endothelial11.05
CD14+_Monocytes11.75
CD19+_BCells(neg._sel.)11.15
CD33+_Myeloid14.25
CD34+12.6
CD4+_Tcells12.15
CD56+_NKCells13
CD71+_EarlyErythroid10.4
CD8+_Tcells10.5
CardiacMyocytes31.15
Caudatenucleus10.1
Cerebellum9
CerebellumPeduncles12.9
CiliaryGanglion11.9
CingulateCortex11.25
Colorectaladenocarcinoma11.15
DorsalRootGanglion9
FetalThyroid10.8
Fetalbrain10.4
Fetalliver9.85
Fetallung8.75
GlobusPallidus8.6
Heart48.3
Hypothalamus11.7
Kidney9.75
Leukemia_chronicMyelogenousK-56211.15
Leukemia_promyelocytic-HL-609.35
Leukemialymphoblastic(MOLT-4)8.55
Liver15.95
Lung12.05
Lymphnode9.45
Lymphoma_burkitts(Daudi)14.55
Lymphoma_burkitts(Raji)16.65
MedullaOblongata10.15
OccipitalLobe10.05
OlfactoryBulb8.75
Ovary8.65
Pancreas8.85
PancreaticIslet11.85
ParietalLobe13.05
Pituitary13
Placenta10.5
Pons11.15
PrefrontalCortex13.9
Prostate12.2
Salivarygland9.1
SkeletalMuscle14.75
Skin9.45
SmoothMuscle12.45
Spinalcord11.9
SubthalamicNucleus10.45
SuperiorCervicalGanglion12.8
TemporalLobe10.35
Testis9.65
TestisGermCell8.5
TestisIntersitial9.4
TestisLeydigCell11.35
TestisSeminiferousTubule10.75
Thalamus11.6
Thymus7.25
Thyroid12.85
Tongue11.05
Tonsil10.8
Trachea11.45
TrigeminalGanglion12.2
Uterus9
UterusCorpus9.8
WholeBlood11.05
Wholebrain8.7
colon11.15
pineal_day13.1
pineal_night13.06
retina13.825
small_intestine10.75
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_7311_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala14.09 ± 0.54
Basal Forebrain13.63 ± 0.33
Basal Part of Pons14.27 ± 0.19
Cerebellar Cortex13.66 ± 0.28
Cerebellar Nuclei14.03 ± 0.28
Claustrum13.81 ± 0.3
Epithalamus13.66 ± 0.18
Frontal Lobe14.07 ± 0.4
Globus Pallidus14.37 ± 0.15
Hypothalamus13.72 ± 0.51
Insula13.92 ± 0.6
Limbic Lobe14.08 ± 0.37
Mesencephalon13.9 ± 0.3
Myelencephalon14.01 ± 0.42
Occipital Lobe13.86 ± 0.36
Parietal Lobe13.9 ± 0.39
Pontine Tegmentum13.83 ± 0.44
Striatum14.2 ± 0.41
Subthalamus13.75 ± 0.38
Temporal Lobe13.99 ± 0.39
Thalamus14 ± 0.36
White Matter14.23 ± 0.24
Mouse Brain ISH
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
HIC2_HUMAN_603 13 603 615 NLISHLRMHTSPS PRIDE
PAp00068656 14 359 372 GPCPGEEGEGVGDR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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