AutismKB 2.0

Annotation Detail for FLG


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Basic Information Top
Gene Symbol:FLG ( ATOD2 )
Gene Full Name: filaggrin
Band: 1q21.3
Quick LinksEntrez ID:2312; OMIM: 135940; Uniprot ID:FILA_HUMAN; ENSEMBL ID: ENSG00000143631; HGNC ID: 3748
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus1 / 5640121
neonate0 / 310970 
infant0 / 236200 
juvenile1 / 5555617
adult12 / 19391216
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor5 / 9417853
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor2 / 2638457
glioma0 / 1068830 
head and neck tumor0 / 1363020 
kidney tumor0 / 689590 
leukemia0 / 958420 
liver tumor0 / 963590 
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia1 / 9725010
normal97 / 336030728
ovarian tumor0 / 766820 
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor2 / 9025722
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood0 / 1234780 
bone0 / 716550 
bone marrow0 / 488010 
brain4 / 11009893
cervix0 / 481710 
connective tissue0 / 1492550 
ear0 / 162120 
embryonic tissue0 / 2157220 
esophagus0 / 202090 
eye0 / 2110540 
heart0 / 896260 
intestine0 / 2344720 
kidney0 / 2117770 
larynx0 / 241450 
liver0 / 2077430 
lung0 / 3369740 
lymph0 / 442700 
lymph node0 / 916100 
mammary gland5 / 15327132
mouth1 / 6705214
muscle0 / 1077150 
nerve0 / 157680 
ovary0 / 1020510 
pancreas0 / 2148120 
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta0 / 2808250 
prostate0 / 1893450 
salivary gland0 / 201550 
skin94 / 210574446
spleen0 / 539520 
stomach0 / 966190 
testis2 / 3304426
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus3 / 23287812
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 215704_at
Cell line Expression level Expression bar
721_B_lymphoblasts10
Adipocyte11.25
AdrenalCortex19.75
Adrenalgland11
Amygdala10.05
Appendix20.2
AtrioventricularNode19.4
BDCA4+_DentriticCells9.35
Bonemarrow14.85
BronchialEpithelialCells9.8
CD105+_Endothelial11.05
CD14+_Monocytes15.05
CD19+_BCells(neg._sel.)11.55
CD33+_Myeloid13.85
CD34+11.5
CD4+_Tcells12.05
CD56+_NKCells12.2
CD71+_EarlyErythroid11.25
CD8+_Tcells8.95
CardiacMyocytes27.55
Caudatenucleus10.4
Cerebellum9.2
CerebellumPeduncles17.55
CiliaryGanglion14.95
CingulateCortex12.65
Colorectaladenocarcinoma11
DorsalRootGanglion14.7
FetalThyroid12.05
Fetalbrain11.15
Fetalliver10.1
Fetallung7.7
GlobusPallidus11.1
Heart26.7
Hypothalamus10.95
Kidney12
Leukemia_chronicMyelogenousK-5629.75
Leukemia_promyelocytic-HL-609.85
Leukemialymphoblastic(MOLT-4)8.35
Liver23.1
Lung11.75
Lymphnode8.95
Lymphoma_burkitts(Daudi)15.9
Lymphoma_burkitts(Raji)21.75
MedullaOblongata9.65
OccipitalLobe10.25
OlfactoryBulb8.15
Ovary10.85
Pancreas10.15
PancreaticIslet12.1
ParietalLobe14.15
Pituitary13.65
Placenta9.9
Pons12.7
PrefrontalCortex13.85
Prostate12.8
Salivarygland10.2
SkeletalMuscle27.65
Skin390.05
SmoothMuscle13.15
Spinalcord11.5
SubthalamicNucleus11.65
SuperiorCervicalGanglion28.65
TemporalLobe11.2
Testis9
TestisGermCell9.75
TestisIntersitial11.75
TestisLeydigCell13.15
TestisSeminiferousTubule10
Thalamus12.25
Thymus7.55
Thyroid11.75
Tongue21.5
Tonsil11.6
Trachea9.25
TrigeminalGanglion22.4
Uterus8.3
UterusCorpus15.4
WholeBlood11.1
Wholebrain7.35
colon10.2
pineal_day12.54
pineal_night12.3
retina13.325
small_intestine10.7
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P34199
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala2.82 ± 1.07
Basal Forebrain2.39 ± 0.21
Basal Part of Pons2.06 ± 0.46
Cerebellar Cortex2.25 ± 0.77
Cerebellar Nuclei2.72 ± 0.73
Claustrum3.27 ± 0.86
Epithalamus2.07 ± 0.69
Frontal Lobe2.21 ± 0.6
Globus Pallidus2.99 ± 0.26
Hypothalamus2.46 ± 0.64
Insula2.24 ± 0.54
Limbic Lobe2.38 ± 0.64
Mesencephalon2.59 ± 0.74
Myelencephalon2.46 ± 0.72
Occipital Lobe2.5 ± 0.66
Parietal Lobe2.41 ± 0.71
Pontine Tegmentum2.49 ± 0.66
Striatum2.56 ± 0.51
Subthalamus2.54 ± 0.64
Temporal Lobe2.33 ± 0.72
Thalamus2.41 ± 0.59
White Matter3.21 ± 0.69
Mouse Brain ISH
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
FILA_HUMAN_1120 14 1120 1133 QVSTHEQSESAHGR PRIDE
PAp00092838 17 3976 3992 HGSYGSADYDYGESGFR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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