AutismKB 2.0

Annotation Detail for PLXND1


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Basic Information Top
Gene Symbol:PLXND1 ( KIAA0620,MGC75353,PLEXD1 )
Gene Full Name: plexin D1
Band: 3q22.1
Quick LinksEntrez ID:23129; OMIM: 604282; Uniprot ID:PLXD1_HUMAN; ENSEMBL ID: ENSG00000004399; HGNC ID: 9107
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body4 / 7076156
blastocyst3 / 6231948
fetus27 / 56401247
neonate0 / 310970 
infant3 / 23620127
juvenile1 / 5555617
adult120 / 193912161
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma1 / 1747557
breast (mammary gland) tumor8 / 9417884
cervical tumor0 / 343660 
chondrosarcoma4 / 8282348
colorectal tumor3 / 11424626
esophageal tumor0 / 172900 
gastrointestinal tumor5 / 11936941
germ cell tumor18 / 26384568
glioma8 / 10688374
head and neck tumor5 / 13630236
kidney tumor6 / 6895987
leukemia6 / 9584262
liver tumor2 / 9635920
lung tumor4 / 10312738
lymphoma2 / 7175527
non-neoplasia7 / 9725071
normal120 / 336030735
ovarian tumor8 / 76682104
pancreatic tumor5 / 10461647
primitive neuroectodermal tumor of the CNS14 / 125680111
prostate cancer0 / 1026800 
retinoblastoma4 / 4635686
skin tumor17 / 124949136
soft tissue/muscle tissue tumor11 / 12519187
uterine tumor5 / 9025755
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue2 / 13106152
adrenal gland0 / 331970 
ascites0 / 400150 
bladder1 / 2975733
blood6 / 12347848
bone4 / 7165555
bone marrow7 / 48801143
brain41 / 110098937
cervix0 / 481710 
connective tissue6 / 14925540
ear0 / 162120 
embryonic tissue9 / 21572241
esophagus0 / 202090 
eye11 / 21105452
heart11 / 89626122
intestine10 / 23447242
kidney11 / 21177751
larynx2 / 2414582
liver2 / 2077439
lung19 / 33697456
lymph1 / 4427022
lymph node2 / 9161021
mammary gland14 / 15327191
mouth2 / 6705229
muscle5 / 10771546
nerve5 / 15768317
ovary10 / 10205197
pancreas9 / 21481241
parathyroid1 / 2053948
pharynx1 / 4132824
pituitary gland0 / 165850 
placenta19 / 28082567
prostate5 / 18934526
salivary gland0 / 201550 
skin20 / 21057494
spleen3 / 5395255
stomach5 / 9661951
testis5 / 33044215
thymus3 / 8113136
thyroid2 / 4747342
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus11 / 23287847
vascular1 / 5178019
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 38671_at
Cell line Expression level Expression bar
721_B_lymphoblasts15.55
Adipocyte233.7
AdrenalCortex34.3
Adrenalgland52.2
Amygdala34.75
Appendix29.55
AtrioventricularNode24.5
BDCA4+_DentriticCells50.35
Bonemarrow36.15
BronchialEpithelialCells21.2
CD105+_Endothelial119.9
CD14+_Monocytes136.6
CD19+_BCells(neg._sel.)13.8
CD33+_Myeloid150
CD34+123.1
CD4+_Tcells33.8
CD56+_NKCells85.15
CD71+_EarlyErythroid14.95
CD8+_Tcells32.5
CardiacMyocytes94.9
Caudatenucleus29.2
Cerebellum23.85
CerebellumPeduncles37.35
CiliaryGanglion26.3
CingulateCortex36.5
Colorectaladenocarcinoma37.5
DorsalRootGanglion27.95
FetalThyroid100.75
Fetalbrain59.75
Fetalliver24.6
Fetallung84.15
GlobusPallidus23.45
Heart80.35
Hypothalamus48.15
Kidney26.45
Leukemia_chronicMyelogenousK-56228.05
Leukemia_promyelocytic-HL-6021.5
Leukemialymphoblastic(MOLT-4)25.1
Liver47.45
Lung183.85
Lymphnode83.6
Lymphoma_burkitts(Daudi)35.05
Lymphoma_burkitts(Raji)33.5
MedullaOblongata30.8
OccipitalLobe38.75
OlfactoryBulb86.2
Ovary20.9
Pancreas37.85
PancreaticIslet42.7
ParietalLobe51.3
Pituitary35.2
Placenta273.85
Pons29.9
PrefrontalCortex72.75
Prostate47.25
Salivarygland24.4
SkeletalMuscle34.8
Skin23.9
SmoothMuscle69.6
Spinalcord78.9
SubthalamicNucleus24.35
SuperiorCervicalGanglion30.3
TemporalLobe29.35
Testis26.85
TestisGermCell27.75
TestisIntersitial27.7
TestisLeydigCell28
TestisSeminiferousTubule26.25
Thalamus37.6
Thymus129.3
Thyroid60.45
Tongue30.7
Tonsil60.55
Trachea27.25
TrigeminalGanglion28.95
Uterus76.9
UterusCorpus44.15
WholeBlood42.75
Wholebrain43.75
colon27.65
pineal_day64.4
pineal_night79.04
retina74.65
small_intestine31.3
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_515_PI416408490
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala4.09 ± 0.96
Basal Forebrain3.52 ± 0.45
Basal Part of Pons3.51 ± 0.89
Cerebellar Cortex3.24 ± 0.59
Cerebellar Nuclei3.94 ± 0.66
Claustrum3.72 ± 1.03
Epithalamus3.81 ± 0.62
Frontal Lobe3.79 ± 0.68
Globus Pallidus4.69 ± 0.52
Hypothalamus3.69 ± 0.6
Insula3.79 ± 0.36
Limbic Lobe3.74 ± 0.72
Mesencephalon4.13 ± 0.9
Myelencephalon3.88 ± 0.76
Occipital Lobe4.62 ± 0.69
Parietal Lobe3.9 ± 0.74
Pontine Tegmentum3.99 ± 0.79
Striatum3.54 ± 1.02
Subthalamus3.58 ± 0.43
Temporal Lobe3.98 ± 0.65
Thalamus4.04 ± 0.61
White Matter4.87 ± 0.69
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Plxnd1CBCerebellum1.96
2.44
Plxnd1CTXCerebral cortex61.95
64.95
Plxnd1HIPHippocampal region3.81
4.08
Plxnd1HPFHippocampal formation19.33
27.25
Plxnd1HYHypothalamus0.59
0.5
Plxnd1LSXLateral septal complex9.55
8.05
Plxnd1MBMidbrain1.62
1.83
Plxnd1MYMedulla3.98
4.26
Plxnd1OLFOlfactory bulb74.65
87.7
Plxnd1PPons2.05
2.08
Plxnd1PALPallidum3.93
3.61
Plxnd1RHPRetrohippocampal region41.29
54.15
Plxnd1sAMYStriatum-like amygdalar nuclei6.57
7.63
Plxnd1STRStriatum41.32
31.85
Plxnd1STRdStriatum dorsal region50.86
39.12
Plxnd1STRvStriatum ventral region34.74
26.13
Plxnd1THThalamus1.5
1.18
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PLXD1_HUMAN_1634 23 1634 1656 KLNTLAHYKIPEGASLAMSLIDK PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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