AutismKB 2.0

Annotation Detail for FLII


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Basic Information Top
Gene Symbol:FLII ( FLI,FLIL,Fli1,MGC39265 )
Gene Full Name: flightless I homolog (Drosophila)
Band: 17p11.2
Quick LinksEntrez ID:2314; OMIM: 600362; Uniprot ID:FLII_HUMAN; ENSEMBL ID: ENSG00000177731; HGNC ID: 3750
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body10 / 70761141
blastocyst18 / 62319288
fetus66 / 564012117
neonate4 / 31097128
infant0 / 236200 
juvenile5 / 5555689
adult287 / 1939121148
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma2 / 17475114
breast (mammary gland) tumor12 / 94178127
cervical tumor12 / 34366349
chondrosarcoma13 / 82823156
colorectal tumor22 / 114246192
esophageal tumor4 / 17290231
gastrointestinal tumor9 / 11936975
germ cell tumor31 / 263845117
glioma36 / 106883336
head and neck tumor19 / 136302139
kidney tumor16 / 68959232
leukemia30 / 95842313
liver tumor15 / 96359155
lung tumor17 / 103127164
lymphoma8 / 71755111
non-neoplasia8 / 9725082
normal460 / 3360307136
ovarian tumor17 / 76682221
pancreatic tumor17 / 104616162
primitive neuroectodermal tumor of the CNS6 / 12568047
prostate cancer10 / 10268097
retinoblastoma6 / 46356129
skin tumor13 / 124949104
soft tissue/muscle tissue tumor32 / 125191255
uterine tumor8 / 9025788
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue2 / 13106152
adrenal gland4 / 33197120
ascites2 / 4001549
bladder3 / 29757100
blood19 / 123478153
bone15 / 71655209
bone marrow13 / 48801266
brain141 / 1100989128
cervix19 / 48171394
connective tissue9 / 14925560
ear1 / 1621261
embryonic tissue38 / 215722176
esophagus4 / 20209197
eye28 / 211054132
heart19 / 89626211
intestine51 / 234472217
kidney36 / 211777169
larynx1 / 2414541
liver18 / 20774386
lung94 / 336974278
lymph8 / 44270180
lymph node31 / 91610338
mammary gland28 / 153271182
mouth11 / 67052164
muscle12 / 107715111
nerve5 / 15768317
ovary25 / 102051244
pancreas31 / 214812144
parathyroid5 / 20539243
pharynx0 / 413280 
pituitary gland1 / 1658560
placenta37 / 280825131
prostate23 / 189345121
salivary gland5 / 20155248
skin24 / 210574113
spleen8 / 53952148
stomach7 / 9661972
testis64 / 330442193
thymus5 / 8113161
thyroid4 / 4747384
tonsil2 / 16999117
trachea19 / 52413362
umbilical cord2 / 13680146
uterus57 / 232878244
vascular7 / 51780135
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 212025_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts46.2
Adipocyte51.15
AdrenalCortex25.65
Adrenalgland26.15
Amygdala23.55
Appendix23.3
AtrioventricularNode19.8
BDCA4+_DentriticCells114.1
Bonemarrow35
BronchialEpithelialCells71.2
CD105+_Endothelial21.05
CD14+_Monocytes90.3
CD19+_BCells(neg._sel.)31.3
CD33+_Myeloid112.2
CD34+42
CD4+_Tcells49.65
CD56+_NKCells36.8
CD71+_EarlyErythroid23.1
CD8+_Tcells35.2
CardiacMyocytes56.2
Caudatenucleus21.8
Cerebellum21.25
CerebellumPeduncles30.2
CiliaryGanglion16.85
CingulateCortex24.8
Colorectaladenocarcinoma216.85
DorsalRootGanglion16.95
FetalThyroid26.05
Fetalbrain21.1
Fetalliver19.2
Fetallung23.15
GlobusPallidus16.25
Heart64.6
Hypothalamus25.9
Kidney26.3
Leukemia_chronicMyelogenousK-56220.35
Leukemia_promyelocytic-HL-6021.55
Leukemialymphoblastic(MOLT-4)20.9
Liver43.7
Lung126.05
Lymphnode22.75
Lymphoma_burkitts(Daudi)46.9
Lymphoma_burkitts(Raji)49.15
MedullaOblongata20.4
OccipitalLobe23.5
OlfactoryBulb17.65
Ovary18
Pancreas20.1
PancreaticIslet28.7
ParietalLobe25.65
Pituitary29.6
Placenta41.45
Pons24.8
PrefrontalCortex29.25
Prostate62.4
Salivarygland21.55
SkeletalMuscle32.45
Skin18.3
SmoothMuscle47.55
Spinalcord23.5
SubthalamicNucleus17.35
SuperiorCervicalGanglion27.45
TemporalLobe20.95
Testis42.8
TestisGermCell27.6
TestisIntersitial44.1
TestisLeydigCell39.3
TestisSeminiferousTubule29.35
Thalamus28.65
Thymus31.15
Thyroid74.2
Tongue32.55
Tonsil33.05
Trachea31.15
TrigeminalGanglion18.35
Uterus24.2
UterusCorpus26.9
WholeBlood78.9
Wholebrain21.15
colon27.85
pineal_day32.86
pineal_night30.56
retina42.975
small_intestine32.35
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_15598_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala5.51 ± 0.37
Basal Forebrain5.62 ± 0.29
Basal Part of Pons6.06 ± 0.2
Cerebellar Cortex6.05 ± 0.31
Cerebellar Nuclei6.04 ± 0.25
Claustrum5.79 ± 0.31
Epithalamus5.89 ± 0.38
Frontal Lobe5.92 ± 0.32
Globus Pallidus5.83 ± 0.24
Hypothalamus5.72 ± 0.4
Insula5.83 ± 0.33
Limbic Lobe5.76 ± 0.32
Mesencephalon5.88 ± 0.37
Myelencephalon5.82 ± 0.37
Occipital Lobe5.59 ± 0.36
Parietal Lobe5.81 ± 0.33
Pontine Tegmentum5.82 ± 0.33
Striatum5.44 ± 0.27
Subthalamus5.82 ± 0.58
Temporal Lobe5.87 ± 0.3
Thalamus5.88 ± 0.31
White Matter6.44 ± 0.12
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
FliihCBCerebellum35.84
74.97
FliihCTXCerebral cortex100
100
FliihHIPHippocampal region71.74
99.02
FliihHPFHippocampal formation86.11
100
FliihHYHypothalamus100
100
FliihLSXLateral septal complex75.78
55.01
FliihMBMidbrain93.11
100
FliihMYMedulla66.04
93.46
FliihOLFOlfactory bulb100
100
FliihPPons72.29
94.6
FliihPALPallidum88.26
92.01
FliihRHPRetrohippocampal region100
100
FliihsAMYStriatum-like amygdalar nuclei100
88.9
FliihSTRStriatum80.53
61.47
FliihSTRdStriatum dorsal region72.86
56.11
FliihSTRvStriatum ventral region91.56
65.64
FliihTHThalamus100
100
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
FLII_HUMAN_0 0 0 0 GAQATLSSTTK PRIDE
FLII_HUMAN_0 0 0 0 LAEDILNTMFDTSYSK PRIDE
FLII_HUMAN_0 0 0 0 LLQSLLDTR PRIDE
FLII_HUMAN_0 0 0 0 VGLGLGYLELPQINYK PRIDE
FLII_HUMAN_1 11 1 11 MEATGVLPFVR PRIDE
FLII_HUMAN_1115 16 1115 1130 LAEDILNTMFDTSYSK PRIDE
FLII_HUMAN_171 21 171 191 RLVHLQTLVLNGNPLLHAQLR PRIDE
FLII_HUMAN_193 12 193 204 QLPAMTALQTLH PRIDE
FLII_HUMAN_193 14 193 206 QLPAMTALQTLHLR PRIDE
FLII_HUMAN_278 12 278 289 NQLTSLPSAICK PRIDE
FLII_HUMAN_645 7 645 651 FVFLLDR PRIDE
FLII_HUMAN_652 8 652 659 GLDIYVWR PRIDE
FLII_HUMAN_730 16 730 745 VGLGLGYLELPQINYK PRIDE
FLII_HUMAN_764 9 764 772 LLQSLLDTR PRIDE
FLII_HUMAN_874 10 874 883 ADLTALFLPR PRIDE
PAp00004837 25 58 82 LEHLSVSHNNLTTLHGELSSLPSLR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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