AutismKB 2.0

Annotation Detail for ZZEF1


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Basic Information Top
Gene Symbol:ZZEF1 ( FLJ10821,FLJ23789,FLJ45574,KIAA0399,MGC166929,ZZZ4 )
Gene Full Name: zinc finger, ZZ-type with EF-hand domain 1
Band: 17p13.2
Quick LinksEntrez ID:23140; OMIM: NA; Uniprot ID:ZZEF1_HUMAN; ENSEMBL ID: ENSG00000074755; HGNC ID: 29027
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body1 / 7076114
blastocyst4 / 6231964
fetus34 / 56401260
neonate4 / 31097128
infant2 / 2362084
juvenile0 / 555560 
adult107 / 193912155
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor2 / 12794156
bladder carcinoma1 / 1747557
breast (mammary gland) tumor2 / 9417821
cervical tumor1 / 3436629
chondrosarcoma4 / 8282348
colorectal tumor8 / 11424670
esophageal tumor0 / 172900 
gastrointestinal tumor5 / 11936941
germ cell tumor6 / 26384522
glioma13 / 106883121
head and neck tumor5 / 13630236
kidney tumor0 / 689590 
leukemia11 / 95842114
liver tumor0 / 963590 
lung tumor6 / 10312758
lymphoma2 / 7175527
non-neoplasia1 / 9725010
normal172 / 336030751
ovarian tumor5 / 7668265
pancreatic tumor3 / 10461628
primitive neuroectodermal tumor of the CNS1 / 1256807
prostate cancer4 / 10268038
retinoblastoma0 / 463560 
skin tumor2 / 12494916
soft tissue/muscle tissue tumor1 / 1251917
uterine tumor2 / 9025722
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland2 / 3319760
ascites0 / 400150 
bladder1 / 2975733
blood5 / 12347840
bone4 / 7165555
bone marrow1 / 4880120
brain46 / 110098941
cervix2 / 4817141
connective tissue3 / 14925520
ear0 / 162120 
embryonic tissue5 / 21572223
esophagus0 / 202090 
eye10 / 21105447
heart1 / 8962611
intestine17 / 23447272
kidney12 / 21177756
larynx1 / 2414541
liver1 / 2077434
lung19 / 33697456
lymph0 / 442700 
lymph node18 / 91610196
mammary gland5 / 15327132
mouth3 / 6705244
muscle1 / 1077159
nerve0 / 157680 
ovary5 / 10205148
pancreas8 / 21481237
parathyroid1 / 2053948
pharynx1 / 4132824
pituitary gland0 / 165850 
placenta15 / 28082553
prostate7 / 18934536
salivary gland0 / 201550 
skin7 / 21057433
spleen5 / 5395292
stomach6 / 9661962
testis17 / 33044251
thymus6 / 8113173
thyroid1 / 4747321
tonsil0 / 169990 
trachea1 / 5241319
umbilical cord6 / 13680438
uterus5 / 23287821
vascular2 / 5178038
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 212601_at
Cell line Expression level Expression bar
721_B_lymphoblasts17
Adipocyte7.65
AdrenalCortex6.95
Adrenalgland8.55
Amygdala14.35
Appendix6.8
AtrioventricularNode4.3
BDCA4+_DentriticCells31.15
Bonemarrow6.9
BronchialEpithelialCells9.7
CD105+_Endothelial6.4
CD14+_Monocytes9.65
CD19+_BCells(neg._sel.)16.75
CD33+_Myeloid17.4
CD34+8.8
CD4+_Tcells25.55
CD56+_NKCells14.45
CD71+_EarlyErythroid6.55
CD8+_Tcells65.65
CardiacMyocytes7.6
Caudatenucleus6.25
Cerebellum6.25
CerebellumPeduncles10.15
CiliaryGanglion4.55
CingulateCortex14.05
Colorectaladenocarcinoma14.05
DorsalRootGanglion4.8
FetalThyroid8.25
Fetalbrain9.35
Fetalliver5.8
Fetallung8.6
GlobusPallidus4.65
Heart9.4
Hypothalamus14.55
Kidney4.9
Leukemia_chronicMyelogenousK-5629.2
Leukemia_promyelocytic-HL-606.7
Leukemialymphoblastic(MOLT-4)18.25
Liver7.45
Lung57.95
Lymphnode13.05
Lymphoma_burkitts(Daudi)7.75
Lymphoma_burkitts(Raji)7.9
MedullaOblongata6.05
OccipitalLobe6.25
OlfactoryBulb5.05
Ovary4.55
Pancreas5.65
PancreaticIslet10.35
ParietalLobe7.9
Pituitary8.25
Placenta13.2
Pons5.85
PrefrontalCortex16.95
Prostate38
Salivarygland6.6
SkeletalMuscle7.6
Skin4.9
SmoothMuscle8.85
Spinalcord10.75
SubthalamicNucleus7
SuperiorCervicalGanglion6.3
TemporalLobe5.4
Testis5.75
TestisGermCell6.05
TestisIntersitial5.3
TestisLeydigCell7.2
TestisSeminiferousTubule5.75
Thalamus8.75
Thymus27.2
Thyroid35.75
Tongue6.4
Tonsil9.8
Trachea5.8
TrigeminalGanglion6.65
Uterus9.9
UterusCorpus9.4
WholeBlood54.75
Wholebrain8.1
colon12.3
pineal_day12.22
pineal_night8.38
retina8.225
small_intestine16.05
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P350040
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala1.96 ± 0.94
Basal Forebrain1.52 ± 0.17
Basal Part of Pons1.24 ± 0.36
Cerebellar Cortex1.45 ± 0.75
Cerebellar Nuclei1.89 ± 0.73
Claustrum2.47 ± 0.85
Epithalamus1.31 ± 0.78
Frontal Lobe1.44 ± 0.74
Globus Pallidus2.17 ± 0.34
Hypothalamus2.1 ± 1.49
Insula1.46 ± 0.52
Limbic Lobe1.54 ± 0.57
Mesencephalon1.74 ± 0.69
Myelencephalon1.6 ± 0.67
Occipital Lobe1.67 ± 0.6
Parietal Lobe1.58 ± 0.65
Pontine Tegmentum1.63 ± 0.7
Striatum1.7 ± 0.52
Subthalamus1.75 ± 0.65
Temporal Lobe1.45 ± 0.64
Thalamus1.55 ± 0.59
White Matter2.14 ± 0.35
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Zzef1CBCerebellum20.19
23.65
Zzef1CTXCerebral cortex26.25
17.36
Zzef1HIPHippocampal region17.17
15.45
Zzef1HPFHippocampal formation22.53
18.39
Zzef1HYHypothalamus7.77
5.83
Zzef1LSXLateral septal complex2.81
1.71
Zzef1MBMidbrain10.13
8.84
Zzef1MYMedulla22.96
24.88
Zzef1OLFOlfactory bulb23.45
15.42
Zzef1PPons21.2
21.64
Zzef1PALPallidum10.19
9.02
Zzef1RHPRetrohippocampal region32.73
23.29
Zzef1sAMYStriatum-like amygdalar nuclei21.03
14.08
Zzef1STRStriatum11.3
7.56
Zzef1STRdStriatum dorsal region11.21
7.73
Zzef1STRvStriatum ventral region7.91
4.71
Zzef1THThalamus6.55
5.19
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00040802 19 1256 1274 HQVCPELELEASWPTHPHR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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