AutismKB 2.0

Annotation Detail for DCUN1D4


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Basic Information Top
Gene Symbol:DCUN1D4 ( FLJ42355,KIAA0276 )
Gene Full Name: DCN1, defective in cullin neddylation 1, domain containing 4 (S. cerevisiae)
Band: 4q12
Quick LinksEntrez ID:23142; OMIM: 612977; Uniprot ID:DCNL4_HUMAN; ENSEMBL ID: ENSG00000109184; HGNC ID: 28998
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body2 / 7076128
blastocyst2 / 6231932
fetus44 / 56401278
neonate2 / 3109764
infant0 / 236200 
juvenile2 / 5555635
adult86 / 193912144
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor1 / 9417810
cervical tumor2 / 3436658
chondrosarcoma2 / 8282324
colorectal tumor1 / 1142468
esophageal tumor0 / 172900 
gastrointestinal tumor8 / 11936967
germ cell tumor19 / 26384572
glioma4 / 10688337
head and neck tumor16 / 136302117
kidney tumor1 / 6895914
leukemia1 / 9584210
liver tumor2 / 9635920
lung tumor1 / 1031279
lymphoma0 / 717550 
non-neoplasia2 / 9725020
normal216 / 336030764
ovarian tumor1 / 7668213
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS1 / 1256807
prostate cancer5 / 10268048
retinoblastoma0 / 463560 
skin tumor3 / 12494924
soft tissue/muscle tissue tumor6 / 12519147
uterine tumor2 / 9025722
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland0 / 331970 
ascites3 / 4001574
bladder1 / 2975733
blood3 / 12347824
bone4 / 7165555
bone marrow1 / 4880120
brain89 / 110098980
cervix2 / 4817141
connective tissue1 / 1492556
ear0 / 162120 
embryonic tissue12 / 21572255
esophagus0 / 202090 
eye11 / 21105452
heart2 / 8962622
intestine5 / 23447221
kidney13 / 21177761
larynx0 / 241450 
liver6 / 20774328
lung7 / 33697420
lymph0 / 442700 
lymph node1 / 9161010
mammary gland3 / 15327119
mouth13 / 67052193
muscle8 / 10771574
nerve3 / 15768190
ovary2 / 10205119
pancreas0 / 2148120 
parathyroid3 / 20539146
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta0 / 2808250 
prostate8 / 18934542
salivary gland4 / 20155198
skin9 / 21057442
spleen0 / 539520 
stomach6 / 9661962
testis45 / 330442136
thymus10 / 81131123
thyroid8 / 47473168
tonsil0 / 169990 
trachea8 / 52413152
umbilical cord0 / 136800 
uterus21 / 23287890
vascular2 / 5178038
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 212855_at
Cell line Expression level Expression bar
721_B_lymphoblasts14
Adipocyte13.4
AdrenalCortex22.05
Adrenalgland12.25
Amygdala60.4
Appendix23.5
AtrioventricularNode20.55
BDCA4+_DentriticCells11.35
Bonemarrow15.1
BronchialEpithelialCells15.75
CD105+_Endothelial47.3
CD14+_Monocytes16.7
CD19+_BCells(neg._sel.)13.9
CD33+_Myeloid18.45
CD34+28.8
CD4+_Tcells13.1
CD56+_NKCells14.85
CD71+_EarlyErythroid13.5
CD8+_Tcells22.1
CardiacMyocytes25.6
Caudatenucleus11.85
Cerebellum11.6
CerebellumPeduncles16.85
CiliaryGanglion15.5
CingulateCortex19.05
Colorectaladenocarcinoma12.6
DorsalRootGanglion15.35
FetalThyroid17.8
Fetalbrain26.4
Fetalliver15.45
Fetallung9.3
GlobusPallidus14.2
Heart27.6
Hypothalamus73.25
Kidney13.45
Leukemia_chronicMyelogenousK-56211.25
Leukemia_promyelocytic-HL-6011.45
Leukemialymphoblastic(MOLT-4)14.55
Liver21.1
Lung13.75
Lymphnode10.15
Lymphoma_burkitts(Daudi)16.5
Lymphoma_burkitts(Raji)23.05
MedullaOblongata12.45
OccipitalLobe16.2
OlfactoryBulb10.6
Ovary12.3
Pancreas12.45
PancreaticIslet17.15
ParietalLobe16.75
Pituitary24.45
Placenta11.45
Pons15.55
PrefrontalCortex78.9
Prostate14.35
Salivarygland12.2
SkeletalMuscle22.2
Skin13.95
SmoothMuscle17.6
Spinalcord24.1
SubthalamicNucleus14.65
SuperiorCervicalGanglion27.6
TemporalLobe13.65
Testis10.5
TestisGermCell17.4
TestisIntersitial12.55
TestisLeydigCell15.15
TestisSeminiferousTubule12.15
Thalamus21.7
Thymus8.65
Thyroid19.3
Tongue18.15
Tonsil13.05
Trachea10.5
TrigeminalGanglion21.75
Uterus45.45
UterusCorpus20.55
WholeBlood13.75
Wholebrain19.55
colon31
pineal_day84.02
pineal_night82.58
retina23.25
small_intestine12.05
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_7019_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala6.71 ± 0.51
Basal Forebrain6.72 ± 0.23
Basal Part of Pons7.05 ± 0.33
Cerebellar Cortex6.56 ± 0.24
Cerebellar Nuclei6.77 ± 0.35
Claustrum6.42 ± 0.58
Epithalamus6.97 ± 0.29
Frontal Lobe7.03 ± 0.43
Globus Pallidus6.93 ± 0.44
Hypothalamus7.38 ± 0.34
Insula6.83 ± 0.32
Limbic Lobe6.9 ± 0.42
Mesencephalon6.97 ± 0.37
Myelencephalon6.88 ± 0.49
Occipital Lobe6.78 ± 0.54
Parietal Lobe7.12 ± 0.38
Pontine Tegmentum6.98 ± 0.42
Striatum6.74 ± 0.42
Subthalamus7.11 ± 0.41
Temporal Lobe7 ± 0.31
Thalamus6.94 ± 0.44
White Matter7.37 ± 0.27
Mouse Brain ISH
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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