AutismKB 2.0

Annotation Detail for CIC


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Basic Information Top
Gene Symbol:CIC ( KIAA0306 )
Gene Full Name: capicua homolog (Drosophila)
Band: 19q13.2
Quick LinksEntrez ID:23152; OMIM: 612082; Uniprot ID:CIC_HUMAN; ENSEMBL ID: ENSG00000079432; HGNC ID: 14214
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body1 / 7076114
blastocyst1 / 6231916
fetus18 / 56401231
neonate0 / 310970 
infant0 / 236200 
juvenile1 / 5555617
adult76 / 193912139
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma2 / 17475114
breast (mammary gland) tumor2 / 9417821
cervical tumor0 / 343660 
chondrosarcoma3 / 8282336
colorectal tumor2 / 11424617
esophageal tumor0 / 172900 
gastrointestinal tumor5 / 11936941
germ cell tumor14 / 26384553
glioma7 / 10688365
head and neck tumor9 / 13630266
kidney tumor0 / 689590 
leukemia6 / 9584262
liver tumor3 / 9635931
lung tumor1 / 1031279
lymphoma3 / 7175541
non-neoplasia4 / 9725041
normal107 / 336030731
ovarian tumor1 / 7668213
pancreatic tumor4 / 10461638
primitive neuroectodermal tumor of the CNS6 / 12568047
prostate cancer7 / 10268068
retinoblastoma2 / 4635643
skin tumor9 / 12494972
soft tissue/muscle tissue tumor8 / 12519163
uterine tumor7 / 9025777
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland1 / 3319730
ascites1 / 4001524
bladder2 / 2975767
blood2 / 12347816
bone3 / 7165541
bone marrow0 / 488010 
brain24 / 110098921
cervix0 / 481710 
connective tissue2 / 14925513
ear0 / 162120 
embryonic tissue5 / 21572223
esophagus0 / 202090 
eye15 / 21105471
heart3 / 8962633
intestine4 / 23447217
kidney5 / 21177723
larynx1 / 2414541
liver3 / 20774314
lung6 / 33697417
lymph2 / 4427045
lymph node8 / 9161087
mammary gland4 / 15327126
mouth2 / 6705229
muscle7 / 10771564
nerve2 / 15768126
ovary1 / 1020519
pancreas15 / 21481269
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta6 / 28082521
prostate14 / 18934573
salivary gland4 / 20155198
skin9 / 21057442
spleen2 / 5395237
stomach4 / 9661941
testis14 / 33044242
thymus0 / 811310 
thyroid2 / 4747342
tonsil1 / 1699958
trachea0 / 524130 
umbilical cord0 / 136800 
uterus8 / 23287834
vascular2 / 5178038
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 212784_at
Cell line Expression level Expression bar
721_B_lymphoblasts119.65
Adipocyte113.45
AdrenalCortex132.6
Adrenalgland97.45
Amygdala136.3
Appendix127
AtrioventricularNode96.1
BDCA4+_DentriticCells129.35
Bonemarrow123.6
BronchialEpithelialCells82.8
CD105+_Endothelial115.5
CD14+_Monocytes150.75
CD19+_BCells(neg._sel.)109.4
CD33+_Myeloid165.35
CD34+126.9
CD4+_Tcells161.4
CD56+_NKCells144.6
CD71+_EarlyErythroid120
CD8+_Tcells127
CardiacMyocytes141.3
Caudatenucleus142.85
Cerebellum109.1
CerebellumPeduncles218.15
CiliaryGanglion75.3
CingulateCortex130.8
Colorectaladenocarcinoma137.25
DorsalRootGanglion83.85
FetalThyroid132.65
Fetalbrain203.95
Fetalliver94.2
Fetallung114.45
GlobusPallidus93.3
Heart130.05
Hypothalamus124.15
Kidney103.05
Leukemia_chronicMyelogenousK-56298.9
Leukemia_promyelocytic-HL-6097.95
Leukemialymphoblastic(MOLT-4)121.7
Liver143.7
Lung147.65
Lymphnode162.4
Lymphoma_burkitts(Daudi)163.2
Lymphoma_burkitts(Raji)177.85
MedullaOblongata128.55
OccipitalLobe122.15
OlfactoryBulb109.7
Ovary102.65
Pancreas95.5
PancreaticIslet136.85
ParietalLobe134.35
Pituitary166.65
Placenta131.7
Pons121.75
PrefrontalCortex175.25
Prostate191.4
Salivarygland82.05
SkeletalMuscle144
Skin97.1
SmoothMuscle134.55
Spinalcord138.65
SubthalamicNucleus110.35
SuperiorCervicalGanglion106.2
TemporalLobe149.5
Testis122.3
TestisGermCell149.3
TestisIntersitial193.05
TestisLeydigCell146.7
TestisSeminiferousTubule185.95
Thalamus104.95
Thymus115.95
Thyroid163.8
Tongue120.65
Tonsil125.75
Trachea94.1
TrigeminalGanglion125.3
Uterus128.75
UterusCorpus97.9
WholeBlood157.4
Wholebrain85.85
colon77.45
pineal_day177.66
pineal_night192.94
retina159.775
small_intestine75.8
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_5670_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala3.57 ± 0.85
Basal Forebrain3.04 ± 0.58
Basal Part of Pons2.77 ± 0.77
Cerebellar Cortex3.42 ± 0.66
Cerebellar Nuclei3.08 ± 0.67
Claustrum3.1 ± 0.74
Epithalamus2.49 ± 0.77
Frontal Lobe2.92 ± 0.77
Globus Pallidus2.5 ± 0.75
Hypothalamus2.53 ± 0.45
Insula3.17 ± 0.51
Limbic Lobe3.03 ± 0.75
Mesencephalon2.92 ± 0.72
Myelencephalon2.95 ± 0.73
Occipital Lobe2.9 ± 0.75
Parietal Lobe2.93 ± 0.75
Pontine Tegmentum3.01 ± 0.79
Striatum2.8 ± 0.71
Subthalamus2.55 ± 0.77
Temporal Lobe3.04 ± 0.74
Thalamus2.75 ± 0.78
White Matter2.57 ± 0.81
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
CicCBCerebellum54.1
62.86
CicCTXCerebral cortex81
64.06
CicHPFHippocampal formation47.67
58.36
CicLSXLateral septal complex16.98
11.88
CicMBMidbrain29.75
25.74
CicMYMedulla37.72
38.01
CicPALPallidum25.93
22.56
CicRHPRetrohippocampal region55.97
48.05
CicsAMYStriatum-like amygdalar nuclei43.34
30.48
CicSTRdStriatum dorsal region34.21
27.59
CicTHThalamus25.16
21.75
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
CIC_HUMAN_601 36 601 636 RPESVGGLEPPGPSVIAAPPSGGGNILQTLVLPPNK PRIDE
PAp00144480 28 559 586 AQESGQGSTAGPLRPPPPGAGGPATPSK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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