AutismKB 2.0

Annotation Detail for FLNB


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Basic Information Top
Gene Symbol:FLNB ( ABP-278,ABP-280,AOI,DKFZp686A1668,DKFZp686O033,FH1,FLN1L,LRS1,SCT,TABP,TAP )
Gene Full Name: filamin B, beta
Band: 3p14.3
Quick LinksEntrez ID:2317; OMIM: 603381; Uniprot ID:FLNB_HUMAN; ENSEMBL ID: ENSG00000136068; HGNC ID: 3755
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body13 / 70761183
blastocyst13 / 62319208
fetus82 / 564012145
neonate20 / 31097643
infant0 / 236200 
juvenile8 / 55556143
adult411 / 1939121211
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma5 / 17475286
breast (mammary gland) tumor20 / 94178212
cervical tumor11 / 34366320
chondrosarcoma7 / 8282384
colorectal tumor54 / 114246472
esophageal tumor0 / 172900 
gastrointestinal tumor28 / 119369234
germ cell tumor29 / 263845109
glioma7 / 10688365
head and neck tumor31 / 136302227
kidney tumor9 / 68959130
leukemia13 / 95842135
liver tumor24 / 96359249
lung tumor7 / 10312767
lymphoma9 / 71755125
non-neoplasia9 / 9725092
normal462 / 3360307137
ovarian tumor17 / 76682221
pancreatic tumor33 / 104616315
primitive neuroectodermal tumor of the CNS1 / 1256807
prostate cancer27 / 102680262
retinoblastoma0 / 463560 
skin tumor7 / 12494956
soft tissue/muscle tissue tumor11 / 12519187
uterine tumor17 / 90257188
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland1 / 3319730
ascites10 / 40015249
bladder3 / 29757100
blood8 / 12347864
bone6 / 7165583
bone marrow4 / 4880181
brain82 / 110098974
cervix20 / 48171415
connective tissue10 / 14925566
ear2 / 16212123
embryonic tissue30 / 215722139
esophagus0 / 202090 
eye19 / 21105490
heart21 / 89626234
intestine85 / 234472362
kidney24 / 211777113
larynx2 / 2414582
liver80 / 207743385
lung43 / 336974127
lymph8 / 44270180
lymph node10 / 91610109
mammary gland41 / 153271267
mouth14 / 67052208
muscle38 / 107715352
nerve2 / 15768126
ovary18 / 102051176
pancreas45 / 214812209
parathyroid8 / 20539389
pharynx8 / 41328193
pituitary gland0 / 165850 
placenta39 / 280825138
prostate52 / 189345274
salivary gland0 / 201550 
skin24 / 210574113
spleen7 / 53952129
stomach18 / 96619186
testis27 / 33044281
thymus24 / 81131295
thyroid16 / 47473337
tonsil0 / 169990 
trachea4 / 5241376
umbilical cord37 / 136802704
uterus31 / 232878133
vascular5 / 5178096
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 208614_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts86.4
Adipocyte49.25
AdrenalCortex63
Adrenalgland43.8
Amygdala19.85
Appendix49.3
AtrioventricularNode77.85
BDCA4+_DentriticCells767.75
Bonemarrow43.2
BronchialEpithelialCells495.75
CD105+_Endothelial48.8
CD14+_Monocytes34.15
CD19+_BCells(neg._sel.)47.55
CD33+_Myeloid73.3
CD34+137.6
CD4+_Tcells58.9
CD56+_NKCells48.15
CD71+_EarlyErythroid36.8
CD8+_Tcells82.2
CardiacMyocytes92.1
Caudatenucleus44.05
Cerebellum39.6
CerebellumPeduncles56.7
CiliaryGanglion47.1
CingulateCortex49.65
Colorectaladenocarcinoma461
DorsalRootGanglion71.4
FetalThyroid111.85
Fetalbrain40.3
Fetalliver41.9
Fetallung40.85
GlobusPallidus33.9
Heart35.5
Hypothalamus62.45
Kidney48.5
Leukemia_chronicMyelogenousK-56244.5
Leukemia_promyelocytic-HL-6039.5
Leukemialymphoblastic(MOLT-4)35.55
Liver49.95
Lung56.1
Lymphnode43.25
Lymphoma_burkitts(Daudi)44.1
Lymphoma_burkitts(Raji)61.4
MedullaOblongata38.8
OccipitalLobe43.85
OlfactoryBulb203.85
Ovary32.8
Pancreas58.45
PancreaticIslet69.9
ParietalLobe42.5
Pituitary73.45
Placenta133.05
Pons46.45
PrefrontalCortex61.8
Prostate245.95
Salivarygland40.5
SkeletalMuscle46.5
Skin39.65
SmoothMuscle118.05
Spinalcord69.1
SubthalamicNucleus38.2
SuperiorCervicalGanglion58.45
TemporalLobe33.7
Testis42.25
TestisGermCell103.2
TestisIntersitial40.6
TestisLeydigCell45.55
TestisSeminiferousTubule42.65
Thalamus51.35
Thymus175.7
Thyroid160.5
Tongue47.8
Tonsil53.35
Trachea44.1
TrigeminalGanglion57.85
Uterus81.35
UterusCorpus43.8
WholeBlood13.1
Wholebrain25.1
colon124.7
pineal_day73.68
pineal_night69.86
retina123.625
small_intestine49.1
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_14400_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala3.36 ± 1.1
Basal Forebrain2.4 ± 0.27
Basal Part of Pons2.79 ± 0.6
Cerebellar Cortex3.26 ± 0.48
Cerebellar Nuclei3.22 ± 0.75
Claustrum3.16 ± 0.91
Epithalamus3.05 ± 0.78
Frontal Lobe2.61 ± 0.81
Globus Pallidus3.44 ± 0.66
Hypothalamus2.68 ± 1.03
Insula2.37 ± 0.74
Limbic Lobe2.87 ± 0.8
Mesencephalon2.95 ± 0.7
Myelencephalon2.89 ± 0.77
Occipital Lobe2.89 ± 0.73
Parietal Lobe2.92 ± 0.99
Pontine Tegmentum2.97 ± 0.96
Striatum3.22 ± 0.88
Subthalamus2.86 ± 0.43
Temporal Lobe2.77 ± 0.74
Thalamus2.81 ± 0.69
White Matter4.28 ± 0.12
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
FlnbCBCerebellum31.26
49.32
FlnbCTXCerebral cortex90.94
64.85
FlnbHIPHippocampal region58.4
90.94
FlnbHPFHippocampal formation64.53
74.4
FlnbHYHypothalamus62.95
48.44
FlnbLSXLateral septal complex26.51
17.16
FlnbMBMidbrain66.5
55.25
FlnbMYMedulla67.94
65.91
FlnbOLFOlfactory bulb55.73
40.2
FlnbPPons63.32
58.45
FlnbPALPallidum49.46
40.1
FlnbRHPRetrohippocampal region74.55
56.26
FlnbsAMYStriatum-like amygdalar nuclei53.05
36.89
FlnbSTRStriatum28.08
18.98
FlnbSTRdStriatum dorsal region25.76
17.52
FlnbSTRvStriatum ventral region23.03
15.07
FlnbTHThalamus100
95.03
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
FLNB_HUMAN_0 0 0 0 IAGPGLGSGVR PRIDE
FLNB_HUMAN_0 0 0 0 IGNLQTDLSDGLR PRIDE
FLNB_HUMAN_0 0 0 0 IQQNTFTR PRIDE
FLNB_HUMAN_0 0 0 0 KIQQNTFTR PRIDE
FLNB_HUMAN_0 0 0 0 LIALLEVLSQK PRIDE
FLNB_HUMAN_0 0 0 0 VLFASQEIPASPFR PRIDE
FLNB_HUMAN_1001 9 1001 1009 NSTAKFIPR PRIDE
FLNB_HUMAN_1044 22 1044 1065 AHGPGLEGGLVGKPAEFTIDTK PRIDE
FLNB_HUMAN_1066 18 1066 1083 GAGTGGLGLTVEGPCEAK PRIDE
FLNB_HUMAN_1125 11 1125 1135 ADIEMPFDPSK PRIDE
FLNB_HUMAN_1219 11 1219 1229 VKVEPAVDTSR PRIDE
FLNB_HUMAN_1299 20 1299 1318 GLHVVEVTYDDVPIPNSPFK PRIDE
FLNB_HUMAN_1354 18 1354 1371 GAGIGGLGITVEGPSESK PRIDE
FLNB_HUMAN_1438 11 1438 1448 VLQSFTVDSSK PRIDE
FLNB_HUMAN_144 8 144 151 LLGWIQNK PRIDE
FLNB_HUMAN_1449 9 1449 1457 AGLAPLEVR PRIDE
FLNB_HUMAN_1519 26 1519 1544 VTASGPGLSSYGVPASLPVDFAIDAR PRIDE
FLNB_HUMAN_1545 19 1545 1563 DAGEGLLAVQITDQEGKPK PRIDE
FLNB_HUMAN_1565 22 1565 1586 AIVHDNKDGTYAVTYIPDKTGR PRIDE
FLNB_HUMAN_1616 13 1616 1628 CLATGPGIASTVK PRIDE
FLNB_HUMAN_1629 12 1629 1640 TGEEVGFVVDAK PRIDE
FLNB_HUMAN_1681 9 1681 1689 PGTYVIYVR PRIDE
FLNB_HUMAN_1756 14 1756 1769 KGEITGEVHMPSGK PRIDE
FLNB_HUMAN_1757 14 1757 1770 KGEITGEVHMPSGK PRIDE
FLNB_HUMAN_1788 14 1788 1801 YAPTEVGLHEMHIK PRIDE
FLNB_HUMAN_1893 14 1893 1906 YNDKHIPGSPFTAK PRIDE
FLNB_HUMAN_1981 23 1981 2003 NGNHVANSPVSIMVVQSEIGDAR PRIDE
FLNB_HUMAN_2016 12 2016 2027 TFEMSDFIVDTR PRIDE
FLNB_HUMAN_2017 12 2017 2028 TFEMSDFIVDTR PRIDE
FLNB_HUMAN_2020 9 2020 2028 MSDFIVDTR PRIDE
FLNB_HUMAN_2058 16 2058 2073 VSYFPTVPGVYIVSTK PRIDE
FLNB_HUMAN_2074 14 2074 2087 FADEHVPGSPFTVK PRIDE
FLNB_HUMAN_2121 19 2121 2139 IPEINSSDMSAHVTSPSGR PRIDE
FLNB_HUMAN_2139 11 2139 2149 VTEAEIVPMGK PRIDE
FLNB_HUMAN_2157 14 2157 2170 FVPQEMGVHTVSVK PRIDE
FLNB_HUMAN_2265 24 2265 2288 FNDEHIPESPYLVPVIAPSDDARR PRIDE
FLNB_HUMAN_2289 13 2289 2301 RLTVMSLQESGLK PRIDE
FLNB_HUMAN_2301 10 2301 2310 VNQPASFAIR PRIDE
FLNB_HUMAN_2322 24 2322 2345 VHSPSGAVEECHVSELEPDKYAVR PRIDE
FLNB_HUMAN_2411 15 2411 2425 AGPGTLSVTIEGPSK PRIDE
FLNB_HUMAN_2475 20 2475 2494 LVSPGSANETSSILVESVTR PRIDE
FLNB_HUMAN_2476 20 2476 2495 LVSPGSANETSSILVESVTR PRIDE
FLNB_HUMAN_2562 14 2562 2575 HVGNQQYNVTYVVK PRIDE
FLNB_HUMAN_2586 16 2586 2601 WGEEHIPGSPFHVTVP PRIDE
FLNB_HUMAN_328 12 328 339 VTVLFAGQHISK PRIDE
FLNB_HUMAN_36 13 36 48 IGNLQTDLSDGLR PRIDE
FLNB_HUMAN_37 13 37 49 IGNLQTDLSDGLR PRIDE
FLNB_HUMAN_429 10 429 438 IFFAGDTIPK PRIDE
FLNB_HUMAN_468 12 468 479 IRETTDFKVDTK PRIDE
FLNB_HUMAN_480 12 480 491 AAGSGELGVTMK PRIDE
FLNB_HUMAN_480 15 480 494 AAGSGELGVTMKGPK PRIDE
FLNB_HUMAN_49 11 49 59 LIALLEVLSQK PRIDE
FLNB_HUMAN_49 12 49 60 LIALLEVLSQKR PRIDE
FLNB_HUMAN_50 11 50 60 LIALLEVLSQK PRIDE
FLNB_HUMAN_522 14 522 535 YSIAITWGGHHIPK PRIDE
FLNB_HUMAN_536 15 536 550 SPFEVQVGPEAGMQK PRIDE
FLNB_HUMAN_553 13 553 565 AWGPGLHGGIVGR PRIDE
FLNB_HUMAN_6 10 6 15 DLAEDAPWKK PRIDE
FLNB_HUMAN_657 16 657 672 SGCIVNNLAEFTVDPK PRIDE
FLNB_HUMAN_678 14 678 691 APLKIFAQDGEGQR PRIDE
FLNB_HUMAN_681 16 681 696 IFAQDGEGQRIDIQMK PRIDE
FLNB_HUMAN_699 13 699 711 MDGTYACSYTPVK PRIDE
FLNB_HUMAN_7 9 7 15 DLAEDAPWK PRIDE
FLNB_HUMAN_715 18 715 732 HTIAVVWGGVNIPHSPYR PRIDE
FLNB_HUMAN_73 20 73 92 QMQLENVSVALEFLDRESIK PRIDE
FLNB_HUMAN_74 16 74 89 QMQLENVSVALEFLDR PRIDE
FLNB_HUMAN_822 14 822 835 VLFASQEIPASPFR PRIDE
FLNB_HUMAN_823 14 823 836 VLFASQEIPASPFR PRIDE
FLNB_HUMAN_857 16 857 872 AGVENGKPTHFTVYTK PRIDE
FLNB_HUMAN_910 22 910 931 YTPTQQGNMQVLVTYGGDPIPK PRIDE
FLNB_HUMAN_931 15 931 945 SPFTVGVAAPLDLSK PRIDE
FLNB_HUMAN_932 15 932 946 SPFTVGVAAPLDLSK PRIDE
PAp00000379 23 2540 2562 AGSNMLLIGVHGPTTPCEEVSMK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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