AutismKB 2.0

Annotation Detail for METAP1


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:METAP1 ( DKFZp781C0419,KIAA0094,MAP1A,MetAP1A )
Gene Full Name: methionyl aminopeptidase 1
Band: 4q23
Quick LinksEntrez ID:23173; OMIM: 610151; Uniprot ID:AMPM1_HUMAN; ENSEMBL ID: ENSG00000164024; HGNC ID: 15789
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body4 / 7076156
blastocyst9 / 62319144
fetus14 / 56401224
neonate6 / 31097192
infant0 / 236200 
juvenile6 / 55556107
adult123 / 193912163
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma4 / 17475228
breast (mammary gland) tumor10 / 94178106
cervical tumor3 / 3436687
chondrosarcoma3 / 8282336
colorectal tumor2 / 11424617
esophageal tumor5 / 17290289
gastrointestinal tumor12 / 119369100
germ cell tumor26 / 26384598
glioma0 / 1068830 
head and neck tumor10 / 13630273
kidney tumor4 / 6895958
leukemia3 / 9584231
liver tumor3 / 9635931
lung tumor3 / 10312729
lymphoma2 / 7175527
non-neoplasia2 / 9725020
normal184 / 336030754
ovarian tumor2 / 7668226
pancreatic tumor1 / 1046169
primitive neuroectodermal tumor of the CNS8 / 12568063
prostate cancer1 / 1026809
retinoblastoma5 / 46356107
skin tumor6 / 12494948
soft tissue/muscle tissue tumor6 / 12519147
uterine tumor10 / 90257110
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland0 / 331970 
ascites1 / 4001524
bladder2 / 2975767
blood3 / 12347824
bone4 / 7165555
bone marrow1 / 4880120
brain36 / 110098932
cervix3 / 4817162
connective tissue5 / 14925533
ear0 / 162120 
embryonic tissue24 / 215722111
esophagus6 / 20209296
eye9 / 21105442
heart1 / 8962611
intestine6 / 23447225
kidney19 / 21177789
larynx5 / 24145207
liver5 / 20774324
lung5 / 33697414
lymph2 / 4427045
lymph node7 / 9161076
mammary gland14 / 15327191
mouth1 / 6705214
muscle4 / 10771537
nerve0 / 157680 
ovary10 / 10205197
pancreas2 / 2148129
parathyroid0 / 205390 
pharynx1 / 4132824
pituitary gland0 / 165850 
placenta14 / 28082549
prostate0 / 1893450 
salivary gland0 / 201550 
skin17 / 21057480
spleen1 / 5395218
stomach19 / 96619196
testis55 / 330442166
thymus8 / 8113198
thyroid4 / 4747384
tonsil1 / 1699958
trachea7 / 52413133
umbilical cord1 / 1368073
uterus18 / 23287877
vascular9 / 51780173
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 212673_at
Cell line Expression level Expression bar
721_B_lymphoblasts392.45
Adipocyte70.45
AdrenalCortex55.4
Adrenalgland46.95
Amygdala96.2
Appendix61.55
AtrioventricularNode47.45
BDCA4+_DentriticCells69.6
Bonemarrow64.3
BronchialEpithelialCells273.4
CD105+_Endothelial119.2
CD14+_Monocytes108.3
CD19+_BCells(neg._sel.)74.65
CD33+_Myeloid90.3
CD34+176.45
CD4+_Tcells170
CD56+_NKCells222.65
CD71+_EarlyErythroid80.05
CD8+_Tcells169.8
CardiacMyocytes85.15
Caudatenucleus56.25
Cerebellum43
CerebellumPeduncles57.55
CiliaryGanglion39.6
CingulateCortex64.65
Colorectaladenocarcinoma60.85
DorsalRootGanglion39.65
FetalThyroid71.5
Fetalbrain129.35
Fetalliver108.25
Fetallung102.05
GlobusPallidus52.85
Heart71.85
Hypothalamus53.6
Kidney54.1
Leukemia_chronicMyelogenousK-56271.95
Leukemia_promyelocytic-HL-60280.3
Leukemialymphoblastic(MOLT-4)157.3
Liver88.1
Lung58.5
Lymphnode130.65
Lymphoma_burkitts(Daudi)279.8
Lymphoma_burkitts(Raji)159.1
MedullaOblongata63.3
OccipitalLobe51.9
OlfactoryBulb36.8
Ovary34.65
Pancreas59.05
PancreaticIslet57.15
ParietalLobe50.2
Pituitary91.1
Placenta60.35
Pons50.6
PrefrontalCortex78.9
Prostate134.25
Salivarygland58.6
SkeletalMuscle63.95
Skin79.05
SmoothMuscle118.1
Spinalcord53.55
SubthalamicNucleus75.8
SuperiorCervicalGanglion120.55
TemporalLobe55.95
Testis133.75
TestisGermCell127.4
TestisIntersitial88.65
TestisLeydigCell58
TestisSeminiferousTubule61.4
Thalamus50.65
Thymus242.35
Thyroid111.45
Tongue97.95
Tonsil101.6
Trachea74
TrigeminalGanglion55
Uterus106.15
UterusCorpus73.15
WholeBlood136.45
Wholebrain73.05
colon128.3
pineal_day46.82
pineal_night49.64
retina63.05
small_intestine118.55
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P226076
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala5.88 ± 0.39
Basal Forebrain5.52 ± 0.29
Basal Part of Pons5.56 ± 0.54
Cerebellar Cortex5.84 ± 0.45
Cerebellar Nuclei5.81 ± 0.55
Claustrum5.7 ± 0.46
Epithalamus5.43 ± 0.39
Frontal Lobe5.67 ± 0.39
Globus Pallidus5.26 ± 0.3
Hypothalamus5.64 ± 0.38
Insula5.64 ± 0.27
Limbic Lobe5.71 ± 0.46
Mesencephalon5.66 ± 0.41
Myelencephalon5.64 ± 0.47
Occipital Lobe5.72 ± 0.4
Parietal Lobe5.72 ± 0.41
Pontine Tegmentum5.59 ± 0.43
Striatum5.33 ± 0.36
Subthalamus5.08 ± 0.59
Temporal Lobe5.72 ± 0.52
Thalamus5.6 ± 0.45
White Matter5.5 ± 0.23
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Metap1CBCerebellum9.41
10.77
Metap1CTXCerebral cortex5.92
4.95
Metap1HIPHippocampal region8.19
8.17
Metap1HPFHippocampal formation7.14
6.46
Metap1HYHypothalamus1.2
0.94
Metap1LSXLateral septal complex2.47
2.99
Metap1MBMidbrain2.49
2.53
Metap1MYMedulla7.16
9.47
Metap1OLFOlfactory bulb5.32
5.25
Metap1PPons5.54
6.7
Metap1PALPallidum0.87
0.91
Metap1RHPRetrohippocampal region5.66
4.32
Metap1sAMYStriatum-like amygdalar nuclei1.32
0.85
Metap1STRStriatum1.07
0.98
Metap1STRdStriatum dorsal region0.62
0.7
Metap1STRvStriatum ventral region2.48
1.66
Metap1THThalamus1.89
1.58
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
AMPM1_HUMAN_147 30 147 176 EVLDVAAGMIKPGVTTEEIDHAVHLACIAR PRIDE
AMPM1_HUMAN_380 7 380 386 PHFMSQF PRIDE
PAp00002281 30 148 177 EVLDVAAGMIKPGVTTEEIDHAVHLACIAR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved