AutismKB 2.0

Annotation Detail for LPIN1


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Basic Information Top
Gene Symbol:LPIN1 ( DKFZp781P1796,KIAA0188,PAP1 )
Gene Full Name: lipin 1
Band: 2p25.1
Quick LinksEntrez ID:23175; OMIM: 605518; Uniprot ID:LPIN1_HUMAN; ENSEMBL ID: ENSG00000134324; HGNC ID: 13345
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body2 / 7076128
blastocyst2 / 6231932
fetus39 / 56401269
neonate1 / 3109732
infant0 / 236200 
juvenile2 / 5555635
adult125 / 193912164
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor2 / 12794156
bladder carcinoma2 / 17475114
breast (mammary gland) tumor5 / 9417853
cervical tumor2 / 3436658
chondrosarcoma1 / 8282312
colorectal tumor2 / 11424617
esophageal tumor0 / 172900 
gastrointestinal tumor10 / 11936983
germ cell tumor8 / 26384530
glioma4 / 10688337
head and neck tumor11 / 13630280
kidney tumor4 / 6895958
leukemia9 / 9584293
liver tumor6 / 9635962
lung tumor0 / 1031270 
lymphoma3 / 7175541
non-neoplasia3 / 9725030
normal273 / 336030781
ovarian tumor3 / 7668239
pancreatic tumor5 / 10461647
primitive neuroectodermal tumor of the CNS18 / 125680143
prostate cancer11 / 102680107
retinoblastoma1 / 4635621
skin tumor6 / 12494948
soft tissue/muscle tissue tumor5 / 12519139
uterine tumor5 / 9025755
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland6 / 33197180
ascites2 / 4001549
bladder1 / 2975733
blood7 / 12347856
bone2 / 7165527
bone marrow8 / 48801163
brain110 / 110098999
cervix2 / 4817141
connective tissue4 / 14925526
ear1 / 1621261
embryonic tissue10 / 21572246
esophagus0 / 202090 
eye8 / 21105437
heart8 / 8962689
intestine9 / 23447238
kidney6 / 21177728
larynx0 / 241450 
liver19 / 20774391
lung6 / 33697417
lymph3 / 4427067
lymph node12 / 91610130
mammary gland13 / 15327184
mouth7 / 67052104
muscle11 / 107715102
nerve1 / 1576863
ovary4 / 10205139
pancreas5 / 21481223
parathyroid1 / 2053948
pharynx3 / 4132872
pituitary gland1 / 1658560
placenta8 / 28082528
prostate12 / 18934563
salivary gland0 / 201550 
skin13 / 21057461
spleen1 / 5395218
stomach10 / 96619103
testis136 / 330442411
thymus6 / 8113173
thyroid5 / 47473105
tonsil1 / 1699958
trachea7 / 52413133
umbilical cord0 / 136800 
uterus25 / 232878107
vascular5 / 5178096
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 212274_at
Cell line Expression level Expression bar
721_B_lymphoblasts158.85
Adipocyte128.1
AdrenalCortex20.7
Adrenalgland16.1
Amygdala62.75
Appendix19.8
AtrioventricularNode15.75
BDCA4+_DentriticCells41.6
Bonemarrow16.2
BronchialEpithelialCells40.1
CD105+_Endothelial17.55
CD14+_Monocytes19.5
CD19+_BCells(neg._sel.)24.8
CD33+_Myeloid24.85
CD34+58.2
CD4+_Tcells102.95
CD56+_NKCells79.45
CD71+_EarlyErythroid7
CD8+_Tcells116.1
CardiacMyocytes17.85
Caudatenucleus17.75
Cerebellum15.35
CerebellumPeduncles22.35
CiliaryGanglion14.25
CingulateCortex22.4
Colorectaladenocarcinoma19.7
DorsalRootGanglion38.45
FetalThyroid18.9
Fetalbrain19.2
Fetalliver14.85
Fetallung15.2
GlobusPallidus14.6
Heart13.2
Hypothalamus51.05
Kidney15.65
Leukemia_chronicMyelogenousK-56217.65
Leukemia_promyelocytic-HL-6015.4
Leukemialymphoblastic(MOLT-4)14.85
Liver25.2
Lung20.25
Lymphnode23.05
Lymphoma_burkitts(Daudi)22.35
Lymphoma_burkitts(Raji)27
MedullaOblongata31.15
OccipitalLobe20.65
OlfactoryBulb160.65
Ovary12.9
Pancreas14.05
PancreaticIslet26.5
ParietalLobe23.85
Pituitary23.15
Placenta19.2
Pons18.65
PrefrontalCortex24.65
Prostate21.25
Salivarygland16.3
SkeletalMuscle24.9
Skin14.6
SmoothMuscle23.3
Spinalcord19.8
SubthalamicNucleus17.5
SuperiorCervicalGanglion22.85
TemporalLobe17.2
Testis20.7
TestisGermCell22.95
TestisIntersitial15.5
TestisLeydigCell19.2
TestisSeminiferousTubule16.8
Thalamus18.7
Thymus37.3
Thyroid27.75
Tongue47.9
Tonsil51.1
Trachea15.9
TrigeminalGanglion41.4
Uterus16.2
UterusCorpus17.7
WholeBlood18.8
Wholebrain15.4
colon21.45
pineal_day85.18
pineal_night161.84
retina24.775
small_intestine19.3
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_9817_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala7.5 ± 0.27
Basal Forebrain7.66 ± 0.35
Basal Part of Pons7.14 ± 0.34
Cerebellar Cortex7.03 ± 0.21
Cerebellar Nuclei7.85 ± 0.27
Claustrum7.78 ± 0.47
Epithalamus7.16 ± 0.37
Frontal Lobe7.14 ± 0.43
Globus Pallidus8.39 ± 0.26
Hypothalamus7.63 ± 0.24
Insula7.12 ± 0.23
Limbic Lobe7.16 ± 0.42
Mesencephalon7.58 ± 0.34
Myelencephalon7.37 ± 0.39
Occipital Lobe7.54 ± 0.33
Parietal Lobe7.36 ± 0.46
Pontine Tegmentum7.46 ± 0.37
Striatum7.88 ± 0.43
Subthalamus7.75 ± 0.22
Temporal Lobe7.24 ± 0.33
Thalamus7.46 ± 0.28
White Matter7.71 ± 0.32
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Lpin1CBCerebellum25.33
41.49
Lpin1CTXCerebral cortex53.59
41.99
Lpin1HIPHippocampal region29.03
34.55
Lpin1HPFHippocampal formation31.65
31.64
Lpin1HYHypothalamus55.23
48.49
Lpin1LSXLateral septal complex25.02
17.91
Lpin1MBMidbrain52.01
56.83
Lpin1MYMedulla63.47
82.32
Lpin1OLFOlfactory bulb54
44.91
Lpin1PPons58.26
74.49
Lpin1PALPallidum57.61
62.08
Lpin1RHPRetrohippocampal region36.48
28.85
Lpin1sAMYStriatum-like amygdalar nuclei62.84
50.4
Lpin1STRStriatum36.19
27.92
Lpin1STRdStriatum dorsal region31.28
24.22
Lpin1STRvStriatum ventral region42.75
31.62
Lpin1THThalamus40.09
36.4
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00095579 17 460 476 DLPSIAISLCGGLSDHR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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