AutismKB 2.0

Annotation Detail for RGL1


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Basic Information Top
Gene Symbol:RGL1 ( KIAA0959,RGL )
Gene Full Name: ral guanine nucleotide dissociation stimulator-like 1
Band: 1q25.3
Quick LinksEntrez ID:23179; OMIM: 605667; Uniprot ID:RGL1_HUMAN; ENSEMBL ID: ENSG00000143344; HGNC ID: 30281
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body5 / 7076170
blastocyst1 / 6231916
fetus31 / 56401254
neonate1 / 3109732
infant0 / 236200 
juvenile1 / 5555617
adult57 / 193912129
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma5 / 8282360
colorectal tumor1 / 1142468
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor6 / 26384522
glioma2 / 10688318
head and neck tumor4 / 13630229
kidney tumor1 / 6895914
leukemia0 / 958420 
liver tumor0 / 963590 
lung tumor0 / 1031270 
lymphoma2 / 7175527
non-neoplasia4 / 9725041
normal172 / 336030751
ovarian tumor0 / 766820 
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS1 / 1256807
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor1 / 1249498
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor3 / 9025733
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue5 / 13106381
adrenal gland1 / 3319730
ascites0 / 400150 
bladder0 / 297570 
blood2 / 12347816
bone2 / 7165527
bone marrow0 / 488010 
brain91 / 110098982
cervix0 / 481710 
connective tissue8 / 14925553
ear0 / 162120 
embryonic tissue9 / 21572241
esophagus0 / 202090 
eye15 / 21105471
heart7 / 8962678
intestine4 / 23447217
kidney5 / 21177723
larynx0 / 241450 
liver0 / 2077430 
lung11 / 33697432
lymph0 / 442700 
lymph node2 / 9161021
mammary gland1 / 1532716
mouth1 / 6705214
muscle1 / 1077159
nerve1 / 1576863
ovary1 / 1020519
pancreas4 / 21481218
parathyroid3 / 20539146
pharynx0 / 413280 
pituitary gland1 / 1658560
placenta4 / 28082514
prostate2 / 18934510
salivary gland3 / 20155148
skin3 / 21057414
spleen2 / 5395237
stomach0 / 966190 
testis19 / 33044257
thymus2 / 8113124
thyroid0 / 474730 
tonsil0 / 169990 
trachea7 / 52413133
umbilical cord0 / 136800 
uterus15 / 23287864
vascular5 / 5178096
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 209568_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts25.25
Adipocyte25.05
AdrenalCortex17.35
Adrenalgland16.2
Amygdala99.45
Appendix17.1
AtrioventricularNode14.8
BDCA4+_DentriticCells10.2
Bonemarrow16.75
BronchialEpithelialCells13.1
CD105+_Endothelial22.65
CD14+_Monocytes14.4
CD19+_BCells(neg._sel.)4.55
CD33+_Myeloid17.5
CD34+8.5
CD4+_Tcells7.45
CD56+_NKCells6.2
CD71+_EarlyErythroid6.65
CD8+_Tcells9.35
CardiacMyocytes22.45
Caudatenucleus46.9
Cerebellum23.45
CerebellumPeduncles24.1
CiliaryGanglion15.7
CingulateCortex39.8
Colorectaladenocarcinoma17.3
DorsalRootGanglion18.25
FetalThyroid17.9
Fetalbrain73.25
Fetalliver14.75
Fetallung49.5
GlobusPallidus19.5
Heart21.4
Hypothalamus99.3
Kidney20.7
Leukemia_chronicMyelogenousK-56211.2
Leukemia_promyelocytic-HL-6014.55
Leukemialymphoblastic(MOLT-4)14.05
Liver20.85
Lung40.85
Lymphnode33.85
Lymphoma_burkitts(Daudi)20.25
Lymphoma_burkitts(Raji)22.25
MedullaOblongata48.25
OccipitalLobe65.9
OlfactoryBulb66.85
Ovary21.05
Pancreas12.6
PancreaticIslet19.1
ParietalLobe66.8
Pituitary22
Placenta19.55
Pons18.65
PrefrontalCortex148.3
Prostate21.95
Salivarygland15.5
SkeletalMuscle17.8
Skin12.05
SmoothMuscle32.75
Spinalcord33.2
SubthalamicNucleus29.75
SuperiorCervicalGanglion32.8
TemporalLobe18.4
Testis44.1
TestisGermCell41.65
TestisIntersitial16.5
TestisLeydigCell18.3
TestisSeminiferousTubule16.3
Thalamus45.55
Thymus26.1
Thyroid23.3
Tongue16.55
Tonsil16.75
Trachea21.85
TrigeminalGanglion19.05
Uterus24.95
UterusCorpus17.5
WholeBlood11.75
Wholebrain52.2
colon16.25
pineal_day33.6
pineal_night26.82
retina114.775
small_intestine26.7
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_32_P223661
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala3.82 ± 0.32
Basal Forebrain3.46 ± 0.35
Basal Part of Pons3.15 ± 0.53
Cerebellar Cortex3.36 ± 0.39
Cerebellar Nuclei3.22 ± 0.53
Claustrum3.35 ± 0.67
Epithalamus3.2 ± 0.7
Frontal Lobe3.57 ± 0.54
Globus Pallidus3.75 ± 0.77
Hypothalamus3.14 ± 0.46
Insula3.58 ± 0.36
Limbic Lobe3.6 ± 0.53
Mesencephalon3.56 ± 0.48
Myelencephalon3.44 ± 0.61
Occipital Lobe3.31 ± 0.42
Parietal Lobe3.44 ± 0.55
Pontine Tegmentum3.61 ± 0.39
Striatum3.22 ± 0.63
Subthalamus3.29 ± 0.05
Temporal Lobe3.5 ± 0.53
Thalamus3.42 ± 0.55
White Matter4.58 ± 0.38
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Rgl1CBCerebellum39.27
50.57
Rgl1CTXCerebral cortex100
100
Rgl1HIPHippocampal region88.33
100
Rgl1HPFHippocampal formation100
100
Rgl1HYHypothalamus70.95
55.71
Rgl1LSXLateral septal complex100
98.63
Rgl1MBMidbrain69.27
62.69
Rgl1MYMedulla51
50.13
Rgl1OLFOlfactory bulb100
100
Rgl1PPons45.92
44.03
Rgl1PALPallidum77.03
71.08
Rgl1RHPRetrohippocampal region100
100
Rgl1sAMYStriatum-like amygdalar nuclei100
100
Rgl1STRStriatum100
100
Rgl1STRdStriatum dorsal region100
93.01
Rgl1STRvStriatum ventral region100
100
Rgl1THThalamus60.32
50.6
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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